Results 21 to 30 of about 18,419 (261)

Polyspecific snake antivenom may help in antivenom crisis [PDF]

BMJ, 2003
EDITOR—In Africa snakebites cause thousands of deaths annually and much permanent physical disability, but the supply of antivenom, the only specific treatment, is threatened by commercial pressures and privatisation. This has been caused over the past few years by the cessation of antivenom manufacture by Behringwerke in Germany, greatly reduced ...
Laing, G, Harrison, R, Theakston, R, Renjifo, J, Nasidi, A, Gutierrez, J, Warrell, D   +6 more
openaire   +4 more sources

The Preclinical Evaluation of a Second-Generation Antivenom for Treating Snake Envenoming in India

Toxins, 2022
Snake envenoming afflicts the Indian subcontinent with the highest rates of mortality (47,000) and morbidity globally. The only effective treatment for snakebites is the administration of antivenom, which is produced by the hyperimmunisation of equines ...
Saurabh S. Attarde, Ashwin Iyer, Suyog Khochare, U. Shaligram, Mayur Vikharankar, K. Sunagar   +5 more
semanticscholar   +1 more source

Potential economic and clinical implications of improving access to snake antivenom in five ASEAN countries: A cost-effectiveness analysis

PLoS Neglected Tropical Diseases, 2022
Background Despite domestic production of antivenoms in the Association of Southeast Asian Nations (ASEAN) countries, not all victims with snakebite envenomings indicated for antivenom received the appropriate or adequate effective dose of antivenom due ...
C. Patikorn, A. Ismail, S. Z. Zainal Abidin, Iekhsan Othman, N. Chaiyakunapruk, S. Taychakhoonavudh   +5 more
semanticscholar   +1 more source

Experimental Bothrops atrox envenomation: Efficacy of antivenom therapy and the combination of Bothrops antivenom with dexamethasone. [PDF]

PLoS Neglected Tropical Diseases, 2017
Bothrops atrox snakes are the leading cause of snake bites in Northern Brazil. The venom of this snake is not included in the antigen pool used to obtain the Bothrops antivenom. There are discrepancies in reports on the effectiveness of this antivenom to
Gabriella Neves Leal Santos Barreto, Sâmella Silva de Oliveira, Isabelle Valle Dos Anjos, Hipocrates de Menezes Chalkidis, Rosa Helena Veras Mourão, Ana Maria Moura-da-Silva, Ida Sigueko Sano-Martins, Luis Roberto de Camargo Gonçalves   +7 more
doaj   +1 more source

Biogeographic venom variation in Russell’s viper (Daboia russelii) and the preclinical inefficacy of antivenom therapy in snakebite hotspots

PLoS Neglected Tropical Diseases, 2021
Background Snakebite in India results in over 58,000 fatalities and a vast number of morbidities annually. The majority of these clinically severe envenomings are attributed to Russell’s viper (Daboia russelii), which has a near pan-India distribution ...
R. R. Senji Laxme, Suyog Khochare, Saurabh S. Attarde, Vivek Suranse, Ashwin Iyer, N. Casewell, R. Whitaker, G. Martin, K. Sunagar   +8 more
semanticscholar   +1 more source

Snakebite: An Exploratory Cost-Effectiveness Analysis of Adjunct Treatment Strategies. [PDF]

, 2018
The cost-effectiveness of the standard of care for snakebite treatment, antivenom, and supportive care has been established in various settings. In this study, based on data from South Indian private health-care providers, we address an additional ...
Bulfone, Tommaso C, Herzel, Benjamin J, Kahn, James G, Lewin, Matthew, Raj, C Soundara, Samuel, Stephen P   +5 more
core   +2 more sources

Proteomics, toxicity and antivenom neutralization of Sri Lankan and Indian Russell’s viper (Daboia russelii) venoms

Journal of Venomous Animals and Toxins including Tropical Diseases, 2021
Background: The western Russell’s viper (Daboia russelii) is widely distributed in South Asia, and geographical venom variation is anticipated among distant populations.
T. Faisal, K. Y. Tan, N. Tan, S. Sim, C. A. Gnanathasan, Choo Hock Tan   +5 more
semanticscholar   +1 more source

Detection of Snake Venom in Post-Antivenom Samples by Dissociation Treatment Followed by Enzyme Immunoassay

Toxins, 2016
Venom detection is crucial for confirmation of envenomation and snake type in snake-bite patients. Enzyme immunoassay (EIA) is used to detect venom, but antivenom in samples prevents venom detection.
Kalana P. Maduwage, Margaret A. O’Leary, Anjana Silva, Geoffrey K. Isbister   +3 more
doaj   +1 more source

A painful journey to antivenom: The therapeutic itinerary of snakebite patients in the Brazilian Amazon (The QUALISnake Study)

PLoS Neglected Tropical Diseases, 2021
Access to antivenoms is not guarranteed for vulnerable populations that inhabit remote areas in the Amazon. The study of therapeutic itineraries (TI) for treatment of snakebites would support strategies to provide timely access to users.
J. Cristino, G. M. Salazar, Vinícius Azevedo Machado, E. Honorato, A. Farias, J. Vissoci, Alexandre Vilhena Silva Neto, M. Lacerda, F. H. Wen, W. Monteiro, Jacqueline Sachett   +10 more
semanticscholar   +1 more source

Pharmacodynamics and pharmacokinetics of snake antivenom

Sri Lanka Journal of Medicine, 2018
Intact or fractionated immunoglobulins are used as snake antivenom to treat snake envenomation. Intravenously administered antivenom binds with snake toxins in the circulation and neutralizes the toxins.
Bhagya Nikapitiya, Kalana Maduwage
doaj   +1 more source