Results 11 to 20 of about 3,627,015 (399)

Compound IMB-Z inhibits hepatitis B virus replication through increasing APOBEC3G expression and incorporation into viral nucleocapsids

open access: yesJournal of Global Antimicrobial Resistance, 2022
: Objectives: As a host restriction factor, apolipoprotein B messenger RNA-editing enzyme catalytic polypeptide-like 3G (APOBEC3G or A3G) has been shown to suppress the replication of several viruses including hepatitis B virus (HBV).
Jin Hu   +6 more
doaj   +1 more source

Quaternized Chitosan Derivatives as Viable Antiviral Agents: Structure–Activity Correlations and Mechanisms of Action

open access: yesACS Applied Materials and Interfaces, 2023
Cationic polysaccharides have demonstrated significant antimicrobial properties and have great potential in medical applications, where the antiviral activity is of great interest. As of today, alcohols and oxidizing agents are commonly used as antiviral
A. Teotia   +3 more
semanticscholar   +1 more source

Establishment and application of a high-throughput screening model for cell adhesion inhibitors

open access: yesFrontiers in Pharmacology, 2023
The cell adhesion between leukocytes and endothelial cells plays an important balanced role in the pathophysiological function, while excessive adhesion caused by etiological agents is associated with the occurrence and development of many acute and ...
Han Sun   +18 more
doaj   +1 more source

Efficacy of Antiviral Agents against the SARS-CoV-2 Omicron Subvariant BA.2

open access: yesNew England Journal of Medicine, 2022
To the Editor: The omicron (B.1.1.529) variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which is responsible for coronavirus disease 2019 (Covid-19), has spread rapidly around the world and has already become the predominant ...
E. Takashita   +15 more
semanticscholar   +1 more source

Efficacy of Antiviral Agents against Omicron Subvariants BQ.1.1 and XBB

open access: yesNew England Journal of Medicine, 2022
. The cells were incubated for 14–18 h at 37 °C and then fixed with formalin. After the formalin was removed, the cells were immunostained with a mouse monoclonal antibody against SARS-CoV-2 nucleoprotein [N45 (TAUNS Laboratories, Inc ...
M. Imai   +12 more
semanticscholar   +1 more source

Repositioning potentials of smallpox vaccines and antiviral agents in monkeypox outbreak: A rapid review on comparative benefits and risks

open access: yesHealth Science Reports, 2022
There is a sought for vaccines and antiviral agents as countermeasures for the recent monkeypox outbreak. Here, we aimed to review and discuss the repurposing potentials of smallpox vaccines and drugs in monkeypox outbreaks based on their comparative ...
M. R. Islam   +6 more
semanticscholar   +1 more source

Synthesis and Applications of Nitrogen-Containing Heterocycles as Antiviral Agents

open access: yesMolecules, 2022
Viruses have been a long-term source of infectious diseases that can lead to large-scale infections and massive deaths. Especially with the recent highly contagious coronavirus (COVID-19), antiviral drugs were developed nonstop to deal with the emergence
Tuyen N. Tran, M. Henary
semanticscholar   +1 more source

Curcumin as an Antiviral Agent [PDF]

open access: yesViruses, 2020
Curcumin, the primary curcuminoid compound found in turmeric spice, has shown broad activity as an antimicrobial agent, limiting the replication of many different fungi, bacteria and viruses. In this review, we summarize recent studies supporting the development of curcumin and its derivatives as broad-spectrum antiviral agents.
Morgan R. Jennings, Robin J. Parks
openaire   +4 more sources

Targeting Liver Sinusoidal Endothelial Cells: An Attractive Therapeutic Strategy to Control Inflammation in Nonalcoholic Fatty Liver Disease

open access: yesFrontiers in Pharmacology, 2021
Nonalcoholic fatty liver disease (NAFLD), especially its advanced stage nonalcoholic steatohepatitis (NASH), has become a threatened public health problem worldwide. However, no specific drug has been approved for clinical use to treat patients with NASH,
Xue-Kai Wang   +3 more
doaj   +1 more source

Isatin derivatives as broad-spectrum antiviral agents: the current landscape

open access: yesMedicinal Chemistry Research, 2022
In recent decades, several viruses have resulted in large outbreaks with serious health, economic and social consequences. The current unprecedented outbreak of the new coronavirus, SARS-COV-2, necessitates intensive efforts for delivering effective ...
T. Elsaman   +6 more
semanticscholar   +1 more source

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