Results 21 to 30 of about 286,395 (314)
Variability in antifungal and antiviral use in hospitalized children [PDF]
, 2017 We analyzed antifungal and antiviral prescribing among high-risk children across freestanding children’s hospitals. Antifungal and antiviral days of therapy varied across hospitals.
Gerber, Jeffrey S +6 more
core +2 more sources
Engineering recombinantly expressed lectin-based antiviral agents
Frontiers in Cellular and Infection Microbiology, 2022 Cyanovirin-N (CV-N), a lectin from Nostoc ellipsosporum was found an infusion inhibitory protein for human immunodeficiency virus (HIV)-1. A tandem-repeat of the engineered domain-swapped dimer bound specific sites at hemagglutinin (HA), Ebola and HIV ...
Irene Maier
doaj +1 more source
The evaluation of liver fibrosis regression in chronic hepatitis C patients after the treatment with direct-acting antiviral agents – A review of the literature [PDF]
, 2019 The second-generation of direct-acting antiviral agents are the current treatment for chronic viral hepatitis C infection. To evaluate the regression of liver fibrosis in patients receiving this therapy, liver biopsy remains the most accurate method, but
Alexescu, Teodora G +12 more
core +3 more sources
A human genome-wide loss-of-function screen identifies effective chikungunya antiviral drugs [PDF]
, 2016 Chikungunya virus (CHIKV) is a globally spreading alphavirus against which there is no commercially available vaccine or therapy. Here we use a genome-wide siRNA screen to identify 156 proviral and 41 antiviral host factors affecting CHIKV replication ...
Berre, Stefano +16 more
core +4 more sources
Medical Clinics of North America, 1988 Potent effective antiviral drugs recently have been licensed for several viral diseases, ushering in a new era in the treatment of viral diseases. Several unique features in the process of a viral infection have been identified as target points for inhibition. The unique steps and the interfering compounds are the subject of this review.
Reines, Eric D., Gross, Peter A.
openaire +2 more sources
Interferon free antiviral treatment of chronic hepatitis C in patients affected by β-thalassemia major [PDF]
, 2017 Chronic hepatitis C (CHC) significantly affects the prognosis of liver disease [1] and health related quality of life (HRQOL) in patients with β-thalassemia major [2, 3].
Biliotti, Elisa +9 more
core +1 more source
Lycorine Derivative LY-55 Inhibits EV71 and CVA16 Replication Through Downregulating Autophagy
Frontiers in Cellular and Infection Microbiology, 2019 Hand, foot, and mouth disease (HFMD) is a global health concern, especially in the Asia-Pacific region. HFMD caused by Enterovirus 71 (EV71) and Coxsackievirus A16 (CVA16) infection is usually self-limited but occasionally leads to severe pulmonary edema,
Huiqiang Wang +7 more
doaj +1 more source
Validation of the SCID-hu Thy/Liv mouse model with four classes of licensed antiretrovirals. [PDF]
, 2007 BackgroundThe SCID-hu Thy/Liv mouse model of HIV-1 infection is a useful platform for the preclinical evaluation of antiviral efficacy in vivo.
A Adachi +67 more
core +6 more sources
mBio, 2022 Amino acid substitutions I38T and E23K in the influenza polymerase acidic (PA) protein lead to reduced susceptibility to the influenza antiviral drug baloxavir.
Paulina Koszalka +4 more
doaj +1 more source
mSphere, 2016 Antimicrobial-resistant infections are an urgent public health threat, and development of novel antimicrobial therapies has been painstakingly slow. Polymicrobial infections are increasingly recognized as a significant source of severe disease and also ...
Jeffrey A. Melvin +6 more
doaj +1 more source