Results 161 to 170 of about 70,871 (236)

Analogous comparison unravels heightened antiviral defense and boosted viral infection upon immunosuppression in bat organoids. [PDF]

Signal Transduct Target Ther, 2022
Liu X, Li C, Wan Z, Chiu MC, Huang J, Yu Y, Zhu L, Cai JP, Rong L, Song YQ, Chu H, Cai Z, Jiang S, Yuen KY, Zhou J.   +14 more
europepmc   +1 more source

Genomic Investigations Unveil the Genetic Underpinnings of Environmental Adaptation in African Goat Populations

Integrative Zoology, EarlyView.
This study integrates genomics and landscape genetics to analyze African goat environmental adaptation. Analyzing 1591 samples, it finds population structure differentiates geographically into four groups, with gene flow between wild Yura goats and North Africans.
Weifeng Peng, Yihua Wang, Yiyuan Zhang, Lei Gao, Lili Wu, Shuping Wang, Yiyang Gao, Wanlu Shi, Kaixin Lu, Rong Deng, Junting Li, Jing Han, Xiaohui Lu, Yujie Liu, Xiaojiao Tang, Yunxia Zhang, Guoyin Li, Li Huang, Mingsheng Yang, Xiaoyan Li   +19 more
wiley   +1 more source

A plant NLR receptor activates auxin signaling through Aux/IAAs-ARF19 and YUC8-TIR1/AFBs to promote callose-mediated antiviral defense. [PDF]

Sci Adv
Yang T, Zhao R, Mei R, Cui H, Ding Z, Wen Y, Wu Q, Chen Z, Huang S, Wang C, Hong L, Zuo W, Zhang Z, Zhu M, Yang L, Zhang Z, Dong S, Xu Y, Tao X.   +18 more
europepmc   +1 more source

Insights from controlled, comparative experiments highlight the limitations of using BSMV and FoMV for virus‐enabled reverse genetics in rice

Annals of Applied Biology, EarlyView.
Virus‐enabled reverse genetics (VERG) enables transient gene expression modulation in plants but its efficacy varies across species. We evaluated the efficacy of barley stripe mosaic virus (BSMV) and foxtail mosaic virus (FoMV) for virus‐induced gene silencing (VIGS) and virus‐mediated overexpression (VOX) in rice (Oryza sativa).
Guilherme M. Turra, Aldo Merotto Jr., Dana R. MacGregor   +2 more
wiley   +1 more source

Elucidating R‐gene‐mediated resistance to wheat dwarf virus in Triticum aestivum genotypes

Annals of Applied Biology, EarlyView.
This study investigates R‐gene‐mediated resistance to wheat dwarf virus (WDV) among different wheat genotypes. Following inoculation with Psammotettix alienus (leafhoppers) and the subsequent appearance of characteristic symptoms such as yellowing and dwarfing, phenotypic responses were evaluated alongside molecular analyses, including quantification ...
Priyanka Krishnamurthy, Emad Ibrahim, Jan Ripl, Jiban K. Kundu   +3 more
wiley   +1 more source

The importance of IP6 for ADAR RNA-editing enzymes and antiviral defense. [PDF]

Proc Natl Acad Sci U S A
Bass BL, Ranganathan S.
europepmc   +1 more source

Novel approaches for drug development against chronic primary pain: A systematic review

British Journal of Pharmacology, EarlyView.
Abstract Chronic primary pain (CPP) persisting for more than 3 months, associated with significant emotional distress without any known underlying cause, is an unmet medical need. Traditional or adjuvant analgesics do not provide satisfactory pain relief for a great proportion of these patients.
Valéria Tékus, Éva Borbély, Andreas Goebel, Ralf Baron, Zsófia Hajna, Zsuzsanna Helyes   +5 more
wiley   +1 more source

Synergistic antiviral activity against human adenovirus through combination of itraconazole and brincidofovir

British Journal of Pharmacology, EarlyView.
Background and Purpose Human adenovirus (HAdV) causes respiratory or gastrointestinal tract infections depending on the virus subtype. While HAdV infections are generally self‐limiting in immunocompetent people, they can result in significant morbidity and mortality in immunocompromised adults and children.
Mohamed Zamzamy, Sophie Post, Wing Hang Ip, Elin Hahlin, Sebastian Kühn, Andrea Pirosu, Christian Conze, Martin Baumdick, Hamburg Intestinal Study Group, Madeleine J. Bunders, Britta F. Zecher, Angelique Hoelzemer, Stephan Linder, Niklas Arnberg, Thomas Dobner, Marcus Altfeld, Sebastian Schloer   +16 more
wiley   +1 more source

PhWRKY30 activates salicylic acid biosynthesis to positively regulate antiviral defense response in petunia. [PDF]

Hortic Res
Wang M, Yuan Y, Zhao Y, Hu Z, Zhang S, Luo J, Jiang CZ, Zhang Y, Sun D.   +8 more
europepmc   +1 more source

Homo sapiens, industrialisation and the environmental mismatch hypothesis

Biological Reviews, EarlyView.
ABSTRACT For the vast majority of the evolutionary history of Homo sapiens, a range of natural environments defined the parameters within which selection shaped human biology. Although human‐induced alterations to the terrestrial biosphere have been evident for over 10,000 years, the pace and scale of change has accelerated dramatically since the onset
Daniel P. Longman, Colin N. Shaw
wiley   +1 more source