Results 31 to 40 of about 70,871 (236)

Antiviral Defenses in Plants through Genome Editing [PDF]

Frontiers in Microbiology, 2017
Plant-virus interactions based-studies have contributed to increase our understanding on plant resistance mechanisms, providing new tools for crop improvement. In the last two decades, RNA interference, a post-transcriptional gene silencing approach, has been used to induce antiviral defenses in plants with the help of genetic engineering technologies.
Romay Gonzalez, Gustavo, Bragard, Claude
openaire   +3 more sources

Roles and programming of Arabidopsis ARGONAUTE proteins during Turnip mosaic virus infection. [PDF]

PLoS Pathogens, 2015
In eukaryotes, ARGONAUTE proteins (AGOs) associate with microRNAs (miRNAs), short interfering RNAs (siRNAs), and other classes of small RNAs to regulate target RNA or target loci.
Hernan Garcia-Ruiz, Alberto Carbonell, J Steen Hoyer, Noah Fahlgren, Kerrigan B Gilbert, Atsushi Takeda, Annalisa Giampetruzzi, Mayra T Garcia Ruiz, Michaela G McGinn, Nicholas Lowery, Maria T Martinez Baladejo, James C Carrington   +11 more
doaj   +1 more source

UNC93B1 mediates innate inflammation and antiviral defense in the liver during acute murine cytomegalovirus infection. [PDF]

PLoS ONE, 2012
Antiviral defense in the liver during acute infection with the hepatotropic virus murine cytomegalovirus (MCMV) involves complex cytokine and cellular interactions.
Meredith J Crane, Pamela J Gaddi, Thais P Salazar-Mather   +2 more
doaj   +1 more source

Research Progress in Plant Antiviral Silencing: Argonaute-Centered Perspective

Guangdong nongye kexue
In the long-term evolution process, plants have evolved multi-layered defense mechanisms to sense and respond to the invasion of harmful organisms such as viruses, to adapt to the adverse environment and avoid attacks from harmful organisms.
Zhaoyun WANG, Jinli XIONG, Xiu WANG
doaj   +1 more source

Antiviral defense mechanisms in honey bees

Current Opinion in Insect Science, 2015
Honey bees are significant pollinators of agricultural crops and other important plant species. High annual losses of honey bee colonies in North America and in some parts of Europe have profound ecological and economic implications. Colony losses have been attributed to multiple factors including RNA viruses, thus understanding bee antiviral defense ...
Brutscher, Laura M, Daughenbaugh, Katie F, Flenniken, Michelle L   +2 more
openaire   +2 more sources

Cell senescence is an antiviral defense mechanism [PDF]

Scientific Reports, 2016
AbstractCellular senescence is often considered a protection mechanism triggered by conditions that impose cellular stress. Continuous proliferation, DNA damaging agents or activated oncogenes are well-known activators of cell senescence. Apart from a characteristic stable cell cycle arrest, this response also involves a proinflammatory phenotype known
Baz-Martínez, Maite, Silva Álvarez, Sabela da, Rodríguez, Estefanía, Guerra Varela, Jorge, El Motiam, Ahmed, Vidal Figueroa, Anxo, García-Caballero Parada, Tomás, González Barcia, Miguel, Sánchez Piñón, Laura, Muñoz Fontela, Cesar, Collado, Manuel, Rivas Vázquez, Carmen   +11 more
openaire   +4 more sources

USP22 controls type III interferon signaling and SARS-CoV-2 infection through activation of STING

Cell Death and Disease, 2022
Pattern recognition receptors (PRRs) and interferons (IFNs) serve as essential antiviral defense against SARS-CoV-2, the causative agent of the COVID-19 pandemic.
Rebekka Karlowitz, Megan L. Stanifer, Jens Roedig, Geoffroy Andrieux, Denisa Bojkova, Marco Bechtel, Sonja Smith, Lisa Kowald, Ralf Schubert, Melanie Boerries, Jindrich Cinatl, Steeve Boulant, Sjoerd J. L. van Wijk   +12 more
doaj   +1 more source

The Evolution of Antiviral Defense Systems [PDF]

Cell Host & Microbe, 2016
Self-replicating genetic material presumably provided the architecture necessary for generating the last universal ancestor of all nucleic-acid-based life. As biological complexity increased in the billions of years that followed, the same genetic material also morphed into a wide spectrum of viruses and other parasitic genetic elements.
openaire   +2 more sources

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source