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Preparing for the Next Influenza Season: Monitoring the Emergence and Spread of Antiviral Resistance [PDF]
Infection and Drug Resistance, 2023 Djin-Ye Oh, Jeanette Milde, Youngsun Ham, Julia Patricia Ramos Calderón, Marianne Wedde, Ralf Dürrwald, Susanne C Duwe Robert Koch Institute, Department 1: Infectious Diseases, Unit 17: Influenza and Other Respiratory Viruses, National Influenza Center ...
Oh DY +6 more
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Cytomegalovirus in children undergoing haematopoietic stem cell transplantation: a diagnostic and therapeutic approach to antiviral resistance [PDF]
Frontiers in Pediatrics, 2023 Cytomegalovirus (CMV) is a ubiquitous virus which causes a mild illness in healthy individuals. In immunocompromised individuals, such as children receiving haematopoietic stem cell transplantation, CMV can reactivate, causing serious disease and ...
Jocelyn Hume +9 more
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Artificial Small RNA-Based Silencing Tools for Antiviral Resistance in Plants [PDF]
Plants, 2020 Artificial small RNAs (art-sRNAs), such as artificial microRNAs (amiRNAs) and synthetic trans-acting small interfering RNAs (syn-tasiRNAs), are highly specific 21-nucleotide small RNAs designed to recognize and silence complementary target RNAs.
Adriana E. Cisneros, Alberto Carbonell
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Strategies and efforts in circumventing the emergence of antiviral resistance against conventional antivirals [PDF]
npj Antimicrobials and ResistanceAntiviral resistance stemming from rapid viral evolution and adaptation is a major challenge faced in treating viral infections. Here, we describe the mechanisms and factors underlying antiviral resistance and their implications to future drug ...
Daryl Zheng Hao Aw +2 more
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Antiviral resistance of stem cells. [PDF]
Curr Opin Immunol, 2019 Stem cells are important for growth and regeneration given their ability to self-renew and differentiate into mature cells. Resistance to certain viral infections has been established as a phenotype of stem cells, a protection in line with their important physiological function.
Wu X, Kwong AC, Rice CM.
europepmc +4 more sources
Influenza viruses – antiviral therapy and resistance
GMS Infectious Diseases, 2017 Influenza is a serious and frequently underestimated, but vaccine preventable disease. The adamantane derivates rimantadine and amantadine and the neuraminidase inhibitors zanamivir and oseltamivir are the only antiviral drugs currently approved in ...
Duwe, Susanne
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Enhanced In Vitro Antiviral Activity of Hydroxychloroquine Ionic Liquids against SARS-CoV-2
Pharmaceutics, 2022 The development of effective antiviral drugs against SARS-CoV-2 is urgently needed and a global health priority. In light of the initial data regarding the repurposing of hydroxychloroquine (HCQ) to tackle this coronavirus, herein we present a ...
Francisco Faísca +5 more
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Interferon Lambda Delays the Emergence of Influenza Virus Resistance to Oseltamivir
Microorganisms, 2021 Influenza viruses are a leading cause of morbidity and mortality worldwide. These air-borne pathogens are able to cross the species barrier, leading to regular seasonal epidemics and sporadic pandemics.
Chiara Medaglia +6 more
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ARHAI: antiviral resistance [PDF]
Journal of Antimicrobial Chemotherapy, 2012 Development of antiviral resistance is a particular concern for the Advisory Committee on Antimicrobial Resistance and Healthcare-Associated Infections (ARHAI). Over the last 4 years, considerable time has been devoted to examining the ability of the UK to monitor the presence and transmission of antiviral resistance. Resistances to antiviral agents in
C Y William, Tong +2 more
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Pathogens, 2022 Baloxavir marboxil (BXM) is an antiviral drug that targets the endonuclease of the influenza polymerase acidic (PA) protein. Antiviral resistance, mainly mediated by the I38T PA substitution, readily occurs in both A(H1N1) and A(H3N2) viruses following a
Amel Saim-Mamoun +3 more
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