Results 21 to 30 of about 135,285 (241)

Mutations in the cytomegalovirus UL97 gene associated with ganciclovir resistance in recipients of allogeneic hematopoietic stem cell transplants [PDF]

Клиническая микробиология и антимикробная химиотерапия, 2019
Objective. To identify mutations in UL97 gene associated with antiviral drug resistance in recipients of allogeneic hematopoietic stem cells transplants (allo-HSCT). Materials and Methods. A total of 9 HCMV DNA samples were studied.
Demin M.V., Tikhomirov D.S., Biderman B.V., Glinshchikova O.A., Drokov M.Yu., Sudarikov A.B., Tupoleva T.A., Filatov F.P.   +7 more
doaj   +1 more source

Variant Analysis of the Thymidine Kinase and DNA Polymerase Genes of Herpes Simplex Virus in Korea: Frequency of Acyclovir Resistance Mutations

Viruses, 2023
The thymidine kinase (TK) and DNA polymerase (pol) genes of the herpes simplex viruses type 1 (HSV-1) and type 2 (HSV-2) are two important genes involved in antiviral resistance.
Jungwon Hyun, Su Kyung Lee, Ji Hyun Kim, Eun-Jung Cho, Han-Sung Kim, Jae-Seok Kim, Wonkeun Song, Hyun Soo Kim   +7 more
doaj   +1 more source

A Case of Disseminated Infection Caused by Streptococcus equi Subspecies zooepidemicus

Canadian Journal of Infectious Diseases and Medical Microbiology, 2009
Human infections with Streptococcus equi subspecies zooepidemicus, a group C streptococcus, are very rare and are generally associated with contact with horses, and consumption of unpasteurized milk products, goat cheese or pork.
Marie-France Poulin, Guy Boivin
doaj   +1 more source

Analysis of cytomegalovirus resistance mutations and clinical features of CMV infection in immunocompromised children [PDF]

Клиническая микробиология и антимикробная химиотерапия
Objective. To determine frequency and spectrum of cytomegalovirus (CMV) resistance mutations to antiviral drugs in immunocompromised children. To study clinical course of resistant CMV infection in this patient population. Materials and Methods. This
Kozhushnaya O.S., Voropaev A.D., Levin P.A., Novichkova G.A., Solopova G.G.   +4 more
doaj   +1 more source

Improved in vitro Efficacy of Baloxavir Marboxil Against Influenza A Virus Infection by Combination Treatment With the MEK Inhibitor ATR-002

Frontiers in Microbiology, 2021
Currently, all available antiviral drugs against influenza virus (IV) that target the virus proteins directly, like Baloxavir acid (BXA), lead to viral resistance.
Hazem Hamza, Hazem Hamza, Mahmoud M. Shehata, Mahmoud M. Shehata, Ahmed Mostafa, Ahmed Mostafa, Ahmed Mostafa, Stephan Pleschka, Stephan Pleschka, Oliver Planz   +9 more
doaj   +1 more source

Technical Validation of a Hepatitis C Virus Whole Genome Sequencing Assay for Detection of Genotype and Antiviral Resistance in the Clinical Pathway

Frontiers in Microbiology, 2020
Choice of direct acting antiviral (DAA) therapy for Hepatitis C Virus (HCV) in the United Kingdom and similar settings usually requires knowledge of the genotype and, in some cases, antiviral resistance (AVR) profile of the infecting virus.
Carmen F. Manso, David F. Bibby, Kieren Lythgow, Hodan Mohamed, Richard Myers, David Williams, Renata Piorkowska, Yuen T. Chan, Rory Bowden, M. Azim Ansari, M. Azim Ansari, Camilla L. C. Ip, Eleanor Barnes, Daniel Bradshaw, Jean L. Mbisa, Jean L. Mbisa   +15 more
doaj   +1 more source

Antiviral Resistance in Human Cytomegalovirus Due to UL54 Mutations Without UL97 Mutations

Annals of Clinical Microbiology, 2022
Background: The concurrent detection of human cytomegalovirus (CMV) with UL97 and UL54 mutations is crucial for prescribing adequate antiviral treatment when drug-resistant CMV infection is suspected.
Kuenyoul Park, Kyu-Hwa Hur, Heungsup Sung, Sang-Ho Choi, Mi-Na Kim   +4 more
doaj   +1 more source

Antivirals Targeting the Surface Glycoproteins of Influenza Virus: Mechanisms of Action and Resistance

Viruses, 2021
Hemagglutinin and neuraminidase, which constitute the glycoprotein spikes expressed on the surface of influenza A and B viruses, are the most exposed parts of the virus and play critical roles in the viral lifecycle.
Yaqin Bai, Jeremy C. Jones, Sook-San Wong, Mark Zanin   +3 more
doaj   +1 more source

Surveillance for antiviral resistance [PDF]

Influenza and Other Respiratory Viruses, 2012
Please cite this paper as: Zambon. (2012) Surveillance for antiviral resistance. Influenza and Other Respiratory Viruses 7(Suppl. 1), 37–43.In the 10 years since licensure of neuraminidase inhibitor drugs, their use has steadily increased, especially during the pandemic of 2009.
openaire   +2 more sources

Antiviral Agents: Discovery to Resistance [PDF]

Viruses, 2020
In the midst of the SARS-CoV-2/Covid-19 outbreak the need for research into, and development of, antiviral agents is brought into sharp focus worldwide for scientists, governments and the public alike [...]
openaire   +4 more sources