Results 31 to 40 of about 135,285 (241)

Influenza antivirals: efficacy and resistance [PDF]

Influenza and Other Respiratory Viruses, 2012
The inaugural conference of the Antiviral Group of the International Society for Influenza and other Respiratory Virus Diseases (ISIRV-AVG) was organised in conjunction with the Oswaldo Cruz Foundation (FIOCRUZ) in Rio de Janeiro, Brazil, in November 2011.
Marilda, Siqueira, Alan, Hay
openaire   +2 more sources

Whole genome analysis of hepatitis B virus before and during long-term therapy in chronic infected patients: Molecular characterization, impact on treatment and liver disease progression

Frontiers in Microbiology, 2022
Hepatitis B virus (HBV) infection remains a serious public health concern worldwide despite the availability of an efficient vaccine and the major improvements in antiviral treatments.
Zeineb Belaiba, Zeineb Belaiba, Kaouther Ayouni, Kaouther Ayouni, Mariem Gdoura, Mariem Gdoura, Wafa Kammoun Rebai, Henda Touzi, Amel Sadraoui, Walid Hammemi, Lamia Yacoubi, Salwa Abdelati, Lamine Hamzaoui, Mohamed Msaddak Azzouz, Anissa Chouikha, Anissa Chouikha, Henda Triki, Henda Triki   +17 more
doaj   +1 more source

Modeling Viral Infectious Diseases and Development of Antiviral Therapies Using Human Induced Pluripotent Stem Cell-Derived Systems

Viruses, 2015
The recent biotechnology breakthrough of cell reprogramming and generation of induced pluripotent stem cells (iPSCs), which has revolutionized the approaches to study the mechanisms of human diseases and to test new drugs, can be exploited to generate ...
Marta Trevisan, Alessandro Sinigaglia, Giovanna Desole, Alessandro Berto, Monia Pacenti, Giorgio Palù, Luisa Barzon   +6 more
doaj   +1 more source

Inhibitors of the Hepatitis C Virus Polymerase; Mode of Action and Resistance

Viruses, 2015
The hepatitis C virus (HCV) is a pandemic human pathogen posing a substantial health and economic burden in both developing and developed countries. Controlling the spread of HCV through behavioural prevention strategies has met with limited success and ...
Auda A. Eltahla, Fabio Luciani, Peter A. White, Andrew R. Lloyd, Rowena A. Bull   +4 more
doaj   +1 more source

Effect of Baloxavir and Oseltamivir in Combination on Infection with Influenza Viruses with PA/I38T or PA/E23K Substitutions in the Ferret Model

mBio, 2022
Amino acid substitutions I38T and E23K in the influenza polymerase acidic (PA) protein lead to reduced susceptibility to the influenza antiviral drug baloxavir.
Paulina Koszalka, Ankita George, Vijaykrishna Dhanasekaran, Aeron C. Hurt, Kanta Subbarao   +4 more
doaj   +1 more source

Efforts to Identify and Combat Antimicrobial Resistance in Uganda: A Systematic Review

Tropical Medicine and Infectious Disease, 2021
The global burden of antimicrobial resistance is on the rise, resulting in higher morbidity and mortality in our communities. The spread of antimicrobial resistance in the environment and development of resistant microbes is a challenge to the control of
Mark Tefero Kivumbi, Claire J. Standley
doaj   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Cytomegalovirus: A tale of resistance [PDF]

Medicinski Podmladak, 2019
Cytomegalovirus (CMV) is a pathogen that affects the majority of the world's population. It may exhibit a wide spectrum of clinical manifestations, ranging from asymptomatic infection in the healthy, congenital disease of the new-born to downright life ...
Janković Marko, Jovanović Tanja
doaj  

Clinical Implications of Antiviral Resistance in Influenza

Viruses, 2015
Influenza is a major cause of severe respiratory infections leading to excessive hospitalizations and deaths globally; annual epidemics, pandemics, and sporadic/endemic avian virus infections occur as a result of rapid, continuous evolution of influenza ...
Timothy C. M. Li, Martin C. W. Chan, Nelson Lee   +2 more
doaj   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source