Results 41 to 50 of about 290,331 (256)

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

rSNP_Guide-BASED EVALUATION OF SNPs IN PROMOTеRS OF THE HUMAN APC AND MLH1 GENES ASSOCIATED WITH COLON CANCER

Вавиловский журнал генетики и селекции, 2015
Six regulatory SNPs (single nucleotide polymorphisms) of two human APC and MLH1 genes (rs75996864, rs76241113, rs78037487, rs80112297, rs80313086 and rs1800734) were evaluated by the previously developed rSNP_Guide method to compute the significance of ...
D. A. Rasskazov, E. V. Antontseva, L. O. Bryzgalov, M. Yu. Matveeva, E. V. Kashina, P. M. Ponomarenko, G. V. Orlova, M. P. Ponomarenko, D. A. Afonnikov, T. I. Merkulova   +9 more
doaj  

Amélioration du niveau des apprenants ou « résultats abusifs » ? : Enquête auprès des enseignant(e)s de 4ème année primaire du Gabon sur les grilles de correction APC [PDF]

Akofena, 2020
Résumé: Dans le cadre des débats fréquents sur l’Approche par les compétences de base au Gabon, nous nous sommes intéressés aux enseignants du primaire, qui sont tenus d’utiliser cette approche dans leurs salles de classe.
Jean-Aimé PAMBOU & Jean Jacques ESSONO ENY
doaj  

BCG vaccination potentiates oxidative phosphorylation in neonatal myeloid‐derived suppressor cells

FEBS Open Bio, EarlyView.
BCG vaccination enhances oxidative phosphorylation in neonatal MDSCs, impairing their immunosuppressive function. It upregulates electron transport chain genes and mitochondrial activity, increasing ATP and oxygen consumption. Pharmacological OXPHOS inhibition partially restores suppressive capacity, confirming causality.
Yingying Chen, Hui Li
wiley   +1 more source

Burden of laryngeal cancer in China caused by smoking from 1990 to 2021 and predictions for 2035: An age-period-cohort analysis of global burden of disease study 2021

Tobacco Induced Diseases
Introduction Smoking is a major risk factor for laryngeal cancer (LC). Understanding the impact of smoking on the changing disease burden of LC is crucial for LC prevention in China and provides a scientific basis for formulating targeted LC prevention ...
Xue Gu, Xiaopeng Sun, Xiao Ren, Yu Li, Yingying Fang, Hui Song, Pingli Luo, Mengfan Yuan   +7 more
doaj   +1 more source

Intracerebral Hemorrhage Induces Monocyte TNF Signaling in Patients That Is Suppressed by BAF312

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Intracerebral hemorrhage (ICH) causes high morbidity and mortality, with neurotoxic inflammation driven by infiltrating monocytes. This study is an in‐depth longitudinal examination of the immune response during the first week of ICH in the presence and absence of the immunomodulatory drug BAF312 (Siponimod).
Jonathan Howard DeLong, Sebastian Díaz‐Pérez, Kevin Navin Sheth, Jang‐Ho Cha, C. J. Malanga, Patricia G. M. Wagner, Nicole Pezous, Aurelie Hanin, Kyle B. Walsh, H. E. Hinson, Lauren Hachmann Sansing   +10 more
wiley   +1 more source

Giant rectal fecaloma treated with carbonated soft drink and argon plasma coagulation

European Journal of Case Reports in Internal Medicine
Constipation is a common gastrointestinal disorder affecting approximately 15% of the population, with a higher prevalence in women and older adults. It can be classified as primary, including functional constipation, pelvic floor dysfunction, and slow ...
Philippe Attieh, Karam Karam, Elias Fiani, Ihab I. El Hajj   +3 more
doaj   +1 more source

Interpersonal variability of the human gut virome confounds disease signal detection in IBD

Communications Biology, 2023
A longitudinal analysis of unamplified fecal virome of healthy controls and IBD patients reveals interpersonal variability is a factor that limits our ability to identify associations between the virome composition and IBD.
Stephen R. Stockdale, Andrey N. Shkoporov, Ekaterina V. Khokhlova, Karen M. Daly, Siobhan A. McDonnell, Orla O’ Regan, James A. Nolan, Thomas D. S. Sutton, Adam G. Clooney, Feargal J. Ryan, Donal Sheehan, Aonghus Lavelle, Lorraine A. Draper, Fergus Shanahan, R. Paul Ross, Colin Hill   +15 more
doaj   +1 more source

β‐Catenin/c‐Myc Axis Modulates Autophagy Response to Different Ammonia Concentrations

Advanced Biology, Volume 9, Issue 3, March 2025.
Ammonia, detoxified by the liver into urea and glutamine, impacts autophagy differently at varying levels. Low ammonia activates autophagy via c‐Myc and β‐catenin, while high levels suppress it. Using Huh7 cells and Spf‐ash mice, c‐Myc's role in cytoprotective autophagy is revealed, offering insights into hyperammonemia and potential therapeutic ...
S. Sergio, B. Spedicato, G. Corallo, A. Inguscio, M. Greco, D. Musarò, D. Vergara, A. F. Muro, G. De Sabbata, L. R. Soria, N. Brunetti Pierri, M. Maffia   +11 more
wiley   +1 more source

Human Kid is Degraded by the APC/CCdh1 but Not by the APC/CCdc20 [PDF]

Cell Cycle, 2007
The APC/C(Cdh1) (anaphase promoting complex/cyclosome) targets numerous cell cycle proteins for ubiquitin mediated degradation in late mitosis and G1. The KEN box is one of two major recognition motifs of APC/C(Cdh1) substrates. This motif is however very common and shared by a tenth of the human proteome, the vast majority of which are obviously not ...
Oren, Feine, Amit, Zur, Hiro, Mahbubani, Michael, Brandeis   +3 more
openaire   +2 more sources