The therapeutic potential of apelin in kidney disease [PDF]
Nature Reviews Nephrology, 2021 Chronic kidney disease (CKD) is a leading cause of global morbidity and mortality and is independently associated with cardiovascular disease. The mainstay of treatment for CKD is blockade of the renin–angiotensin–aldosterone system (RAAS), which reduces
Fiona A Chapman +2 more
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PLoS ONE, 2022 Background The present systematic review and meta-analysis aimed to ascertain if the circulating levels of apelin, as an important regulator of the cardiovascular homeostasis, differ in patients with cardiovascular diseases (CVDs) and controls. Methods A
Hamed Akbari +8 more
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Myocardial injection of apelin-overexpressing bone marrow cells improves cardiac repair via upregulation of Sirt3 after myocardial infarction. [PDF]
PLoS ONE, 2013 Our previous study shows that treatment with apelin increases bone marrow cells (BMCs) recruitment and promotes cardiac repair after myocardial infarction (MI).
Lanfang Li +4 more
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The role of apelin in cancer [PDF]
Frontiers in OncologyApelin is widely expressed in the body. Apelin is secreted as a propeptide and is proteolytically cleaved into six main isoforms. As an adipokine, apelin has a cardio- and neuroprotective role and is involved in angiogenesis in healthy tissue.
Yuki Agarwala, Rohini Sharma
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Cells, 2022 Prostate cancer commonly affects the urinary tract of men and metastatic prostate cancer has a very low survival rate. Apelin belongs to the family of adipokines and is associated with cancer development and metastasis.
Tien-Huang Lin +13 more
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Repression of apelin Furin cleavage sites provides antimetastatic strategy in colorectal cancer [PDF]
EMBO Molecular MedicineThe adipokine apelin has been directly implicated in various physiological processes during embryogenesis and human cancers. Nevertheless, the importance of the conversion of its precursor proapelin to mature apelin in tumorigenesis remains unknown.
Béatrice Demoures +21 more
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Apelin ameliorates TNF-α-induced reduction of glycogen synthesis in the hepatocytes through G protein-coupled receptor APJ. [PDF]
PLoS ONE, 2013 Apelin, a novel adipokine, is the specific endogenous ligand of G protein-coupled receptor APJ. Consistent with its putative role as an adipokine, apelin has been linked to states of insulin resistance.
Jiaojiao Chu +8 more
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Apelin/APJ system: a novel promising target for anti-oxidative stress in stroke [PDF]
Frontiers in PharmacologyThe apelin/APJ system has garnered increasing attention in recent years. In this review, we comprehensively discuss the physiological and pathological mechanisms of the apelin/APJ system in stroke. The apelin/APJ system is widely expressed in the central
Weilin Xu +16 more
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An endothelial apelin-FGF link mediated by miR-424 and miR-503 is disrupted in pulmonary arterial hypertension [PDF]
Nature Medicine, 2012 Jongmin Kim +2 more
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A reactive oxygen species-responsive hydrogel loaded with Apelin-13 promotes the repair of spinal cord injury by regulating macrophage M1/M2 polarization and neuroinflammation [PDF]
Journal of NanobiotechnologySpinal cord injury (SCI) is a chronic condition whereby persistent aberrant macrophage activation hinders the repair process. During acute trauma, dominant M1 macrophages produce high levels of reactive oxygen species (ROS), leading to increased ...
Zhiyue Li +5 more
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