Results 1 to 10 of about 15,683 (226)

The therapeutic potential of apelin in kidney disease

Nature Reviews Nephrology, 2021
Chronic kidney disease (CKD) is a leading cause of global morbidity and mortality and is independently associated with cardiovascular disease. The mainstay of treatment for CKD is blockade of the renin–angiotensin–aldosterone system (RAAS), which reduces
Fiona A Chapman, Duuamene Nyimanu, Janet J Maguire   +2 more
exaly   +2 more sources

APELIN-12 AND APELIN-36 IN SPUTUM OF PATIENTS WITH BRONCHIAL ASTHMA

Учёные записки Санкт-Петербургского государственного медицинского университета им. Акад. И.П. Павлова, 2017
Relevance. In recent years, adipokines are considered as participants of pathogenesis in bronchial asthma (BA). The vast majority of studies on adipokines is based on the study of plasma (systemic) levels of adipokines.
V. N. Mineev, A. A. Kuzmina
doaj   +2 more sources

The role of apelin in cancer [PDF]

Frontiers in Oncology
Apelin is widely expressed in the body. Apelin is secreted as a propeptide and is proteolytically cleaved into six main isoforms. As an adipokine, apelin has a cardio- and neuroprotective role and is involved in angiogenesis in healthy tissue.
Yuki Agarwala, Rohini Sharma
doaj   +2 more sources

MicroRNA-122-5p Aggravates Angiotensin II-Mediated Myocardial Fibrosis and Dysfunction in Hypertensive Rats by Regulating the Elabela/Apelin-APJ and ACE2-GDF15-Porimin Signaling [PDF]

Journal of Cardiovascular Translational Research, 2022
Hypertension is the leading risk factor for cardiovascular disorders. This study aimed to explore roles of microRNA (miR)-122-5p in hypertension. Angiotensin II (Ang II; 1.5 mg/kg/day) with an osmotic minipump was used to induce hypertensive rats ...
Jiawei Song, Zhenzhou Zhang, Z. Dong, Xinming Liu, Ying Liu, Xueting Li, Yingle Xu, Ying Guo, Ning Wang, Miwen Zhang, Yihang Chen, Haiyan Jin, Jiuchang Zhong   +12 more
semanticscholar   +2 more sources

RUNX3-activated apelin signaling inhibits cell proliferation and fibrosis in diabetic nephropathy by regulation of the SIRT1/FOXO pathway

Diabetology & Metabolic Syndrome
Background Diabetic nephropathy is a major secondary cause of end-stage renal disease. Apelin plays an important role in the development of DN. Understanding the exact mechanism of Apelin can help expand the means of treating DN.
Xin Zhong, Jun Zhang
doaj   +2 more sources

Apelin Promotes Prostate Cancer Metastasis by Downregulating TIMP2 via Increases in miR-106a-5p Expression

Cells, 2022
Prostate cancer commonly affects the urinary tract of men and metastatic prostate cancer has a very low survival rate. Apelin belongs to the family of adipokines and is associated with cancer development and metastasis.
Tien-Huang Lin, Sunny Li-Yun Chang, Pham Minh Khanh, Nguyen Thi Nha Trang, Shan-Chi Liu, Hsiao-Chi Tsai, An-Chen Chang, Jo-Yu Lin, Po-Chun Chen, Ju-Fang Liu, Jeng-Hung Guo, Chun-Lin Liu, Hsi-Chin Wu, Chih-Hsin Tang   +13 more
doaj   +2 more sources

The Role of the Apelin/APJ System in the Regulation of Liver Disease [PDF]

Frontiers in Pharmacology, 2017
Apelin is an endogenous peptide that is a ligand for the APJ receptor (angiotensin II receptor like-1, AT-1). The apelin/APJ system is distributed in diverse periphery organ tissues.
Wei-Dong Chen, Wei-Dong Chen, Yan-Dong Wang, Xinrui Lv, Jing Kong   +4 more
doaj   +2 more sources

Apelin-13-Mediated Upregulation of METTL3 Ameliorates Alzheimer’s Disease via Inhibiting Neuroinflammation Through m6A-Dependent Regulation of lncRNA BDNF-AS [PDF]

Biomolecules
Apelin-13, a neuropeptide, has been recognized for its neuroprotective properties. Our previous study found apelin-13 improves cognitive function in Alzheimer’s disease (AD) rats by inhibiting neuroinflammation through upregulation of BDNF/TrkB signaling
Han L, Wei S, Wang R, Liu Y, Zhong Y, Fu J, Luo H, Bao M.   +7 more
europepmc   +2 more sources

Apelin-13 Suppresses Neuroinflammation Against Cognitive Deficit in a Streptozotocin-Induced Rat Model of Alzheimer’s Disease Through Activation of BDNF-TrkB Signaling Pathway

Frontiers in Pharmacology, 2019
Alzheimer’s disease (AD), a progressive neurodegenerative disease characterized by impairments of cognitive function as a result of synaptic deficits and neuronal loss, is associated with inflammation.
Yang Xiang, Chi Liu, Xiao-Qun Qin
exaly   +2 more sources

A reactive oxygen species-responsive hydrogel loaded with Apelin-13 promotes the repair of spinal cord injury by regulating macrophage M1/M2 polarization and neuroinflammation

Journal of Nanobiotechnology
Spinal cord injury (SCI) is a chronic condition whereby persistent aberrant macrophage activation hinders the repair process. During acute trauma, dominant M1 macrophages produce high levels of reactive oxygen species (ROS), leading to increased ...
Zhiyue Li, Qun Zhao, Jiahui Zhou, Yuyan Li, Yifan Zheng, Linxi Chen   +5 more
doaj   +2 more sources