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Neuroprotective Roles of Apelin-13 in Neurological Diseases
Neurochemical Research, 2023Apelin is a natural ligand for the G protein-coupled receptor APJ, and the apelin/APJ system is widely distributed in vivo. Among the apelin family, apelin-13 is the major apelin isoform in the central nervous system and cardiovascular system, and is involved in the regulation of various physiopathological mechanisms such as apoptosis ...
Yang, Zhang +8 more
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Evaluation of Apelin-13 levels in patients with diabetic nephropathy
International Urology and Nephrology, 2022There is no clear information about the level of Apelin-13 in patients with diabetic nephropathy (DN). In this study, we investigated whether there is a relationship between Apelin-13 level and the severity of the disease in patients with DN.In our case-control study, we included patients who applied to the endocrinology outpatient clinic in 2019 ...
Gamze İçen +2 more
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The effects of apelin-13 against cisplatin-induced nephrotoxicity in rats
Drug and Chemical Toxicology, 2021Acute kidney injury (AKI) is observed in nearly 60% of patients undergoing cisplatin (CP) therapy. The aim of this study was to reveal the potential effects of apelin-13 (AP-13) in the prevention of CP-induced renal toxicity, together with its antioxidant and anti-inflammatory effect mechanisms. Four experimental groups were established.
Atilla, Topcu +5 more
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Behavioral, neuroendocrine and thermoregulatory actions of apelin-13
Neuroscience, 2004As the distribution of apelinergic neurons in the brain suggests an important role of apelin-13 in the regulation of neuroendocrine processes, in the present experiments the effects of this recently identified neuropeptide on the open-field activity, the hypothalamo-pituitary-adrenal (HPA) system and the body temperature were investigated.
M, Jászberényi +2 more
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Apelin‐13 treatment enhances the stability of atherosclerotic plaques
European Journal of Clinical Investigation, 2018AbstractBackgroundApelin is an endogenous peptidergic system which modulates cardiovascular function. Recent studies pointed out a fundamental contribution of apelin on atherosclerosis development; however, such reports revealed contradictory data, and to date, it is difficult to accurately define a beneficial or deleterious role.
Rodrigo A. Fraga‐Silva +10 more
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Molecular mechanism of apelin-13 regulation of colonic motility in rats
European Journal of Pharmacology, 2021Apelin is a novel neuropeptide identified as the endogenous ligand for the apelin receptor. Apelin and its receptor are widely distributed in the gastrointestinal tract. Studies have reported that apelin-13 is involved in modulating gastrointestinal motility; however, the evidence is insufficient and the relevant mechanism is still not fully clear ...
Lin, Yan +5 more
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2023
Apelin, a neuropeptide, is a typical endogenous ligand of G protein-coupled apelin receptor, APJ. Apelin mRNAs, proteins and APJ are commonly found in peripheral tissues and the central nervous system (CNS). Thus apelin-APJ system may be related to many physiological and pathological processes such as epilepsy.
AYÇIK, Fatma Banu, AGAR, Erdal
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Apelin, a neuropeptide, is a typical endogenous ligand of G protein-coupled apelin receptor, APJ. Apelin mRNAs, proteins and APJ are commonly found in peripheral tissues and the central nervous system (CNS). Thus apelin-APJ system may be related to many physiological and pathological processes such as epilepsy.
AYÇIK, Fatma Banu, AGAR, Erdal
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The role of apelin-13 in novel object recognition memory
Peptides, 2014Apelin and its receptor APJ (apelin receptor) are prominently expressed in brain regions involved in learning and memory. However, the role of apelin in cognition was largely unclear. Here, the role of apelin-13 in memory processes was investigated in mice novel object recognition task.
Ren-wen, Han +3 more
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Apelin-13 in blood pressure regulation and cardiovascular disease
Current Opinion in Nephrology and Hypertension, 2016Despite extensive pharmacological treatment, hypertension and heart failure still pose as high health and economic burden. Thus, novel therapeutic approaches are needed to promote more effective treatment of hypertension and cardiovascular disease.
Liliya M, Yamaleyeva +2 more
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Apelin-13 enhances contextual fear extinction in rats
Neuroscience Letters, 2019Fear extinction is considered as a new learning process that is valid to model features of post-traumatic stress disorder (PTSD). The neuropeptide apelin, such as apelin-13, apelin-17 and apelin-36, are endogenous ligands of the G-protein coupled receptor APJ.
Fang-Ling, Chen +4 more
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