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Apelin-13: A Protective Role in Vascular Diseases
Current Problems in CardiologyVascular disease is a common problem with high mortality all over the world. Apelin-13, a key subtype of apelin, takes part in many physiological and pathological responses via regulating many target genes and target molecules or participating in many signaling pathways.
Guang-Gui Zeng +5 more
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Intracerebroventricular injection of apelin-13 reduces food intake in the rat
Neuroscience Letters, 2003Apelin is a peptide recently identified as a ligand for the APJ receptor, a receptor located in tissues such as the small intestine and in the hypothalamus. Apelin has been detected in adipose tissue, gastrointestinal tract, heart and stomach. Recent reports suggest a role for apelin in the regulation of blood pressure and the control of body fluid ...
David, Sunter +2 more
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Transmitter mediation of the anxiolytic action of apelin-13 in male mice
Behavioural Brain Research, 2014The widespread distribution of apelin-13 and apelin receptors in the brain and periphery suggests an important function of this neuropeptide in regulatory processes in the organism. In previous work we found that apelin-13 facilitates the consolidation of passive avoidance learning in rats.
Gyula, Telegdy, Miklós, Jászberényi
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Hemodynamic impacts of apelin-13 in a neonatal lamb model of septic peritonitis
Pediatric Research, 2022Apelins are potential candidate therapeutic molecules for hemodynamic support. The objective of this study was to assess the hemodynamic impacts of apelin-13 in a neonatal lamb model of septic shock.Lambs were randomized to receive apelin-13 or normal saline. Septic shock was induced by injecting a fecal slurry into the peritoneal cavity.
Émile, Simard +8 more
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Apelin‐13 inhibits lipid accumulation in human hepatocytes
The FASEB Journal, 2017Background Apelin is an adipokine and acts through a G protein‐coupled receptor named APJ. Its protective function on lipid accumulation in adipocytes has been proven. However, functions of apelin in hepatocytes have not been investigated. METHODS
Soojin Park, Jin Huang, Dongsoon Im
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Evaluation of serum apelin‐13 and apelin‐36 concentrations in preeclamptic pregnancies
Journal of Obstetrics and Gynaecology Research, 2019AbstractAimRecent studies suggest that apelin can be a novel potential therapeutic mediator to improve the diagnosis, and treatment of preeclampsia. This study aimed to investigate the association of serum apelin‐13 and apelin‐36 with preeclampsia and to detect their relationship with preeclampsia‐associated perinatal morbidity.MethodsForty‐four women ...
Beril Gürlek +6 more
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Apelin-13: a novel approach to suppressing renin production in RVHT
American Journal of Physiology-Cell PhysiologyOur research elucidated that apelin-13 inhibits renin production through the cAMP/PKA/soluble (pro)renin receptor pathway, presenting a promising therapeutic approach for renovascular hypertension (RVHT) by targeting renin expression mechanisms. These findings underscore the potential of apelin-13 as a novel strategy to address RVHT.
Ziqing Yan +6 more
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The Role of Apelin 13 in Progression of Chronic Kidney Disease.
Iranian journal of kidney diseases, 2015Apelin is an adipokine secreted by the adipose tissue and by the endothelial cells in various parts of the body. Apelin is also expressed by the glomerular arteriolar rectus and glomerular capillary cells. We evaluated the relationship between the initial serum levels of apelin 13 with the trend of glomerular filtration rate (GFR) during a 1-year ...
Altunoren, Orcun +6 more
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Neuroprotective effect of apelin-13 and other apelin forms—a review
Pharmacological ReportsNeurodegenerative diseases, which occur when neurons begin to deteriorate, affect millions of people worldwide. These age-related disorders are becoming more common partly because the elderly population has increased in recent years. While no treatments are accessible, every year an increasing number of therapeutic and supportive options become ...
Katarzyna Kamińska +3 more
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Apelin-13 Impaires Acquisition but Not Consolidation or Expression of Contextual Fear in Rats
Neurochemical Research, 2016Apelin-13, as an endogenous neuropeptide, is the ligand for the G-protein-coupled receptor, APJ, which has recently been demonstrated to be involved in the process that contributes to learning and memory. Previous studies showed that apelin may be required for certain forms of learning and memory.
Li, Han +4 more
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