Results 91 to 100 of about 15,683 (226)

Altered glucose homeostasis is associated with increased serum apelin levels in type 2 diabetes mellitus.

PLoS ONE, 2012
BackgroundApelin is an adipokine that plays a role in the regulation of glucose homeostasis and in obesity. The relationship between apelin serum concentration and dysmetabolic conditions such as type 2 diabetes (T2D) is still controversial.
Maria Gisella Cavallo, Federica Sentinelli, Ilaria Barchetta, Carmine Costantino, Michela Incani, Laura Perra, Danila Capoccia, Stefano Romeo, Efisio Cossu, Frida Leonetti, Luciano Agati, Marco G Baroni   +11 more
doaj   +1 more source

Apelin hormone level and its role in the etiology of sudden hearing loss

Medicine Science, 2020
Sudden hearing loss (SHL) is a significant problem requiring emergency intervention; however, consensus on its diagnosis and treatment remains to be determined. Although several factors could cause SHL, its cause can only be determined in 10% of patients.
Nuray Ensari, Ozer Erdem Gur, Nilgun Gur, Omer Tarik Selcuk, Levent Renda, Mustafa Deniz Yilmaz, Hulya Eyigor, Yesim Cekin   +7 more
doaj   +1 more source

PD‐L1 on Tumor‐Derived Extracellular Vesicles Induces CD8+ T Cell Terminal Exhaustion and Mediates Anti‐PD‐1 Resistance in Head and Neck Squamous Cell Carcinoma

Advanced Science, Volume 13, Issue 4, 19 January 2026.
Immunotherapy fails in head and neck squamous cell carcinoma (HNSCC) due to terminally exhausted T (Texterm) cells. Tumor‐derived PD‐L1+ extracellular vesicles promote CD8‐Texterm cells differentiation by upregulating BATF. Stromal Texterm density serves as a potent biomarker for predicting immunotherapy resistance, highlighting a novel EV‐mediated ...
Ruihua Fang, Bixue Huang, Yun Li, Zhimou Cai, Yicheng Deng, Xiaoqing Cen, Wei Sun, Jinhong Zhang, Zhenglin Xu, Wenbin Guo, Yi Lyu, Shiyun Luo, Zhesheng Chen, Kexing Lyu, Weiping Wen, Wenbin Lei   +15 more
wiley   +1 more source

Apelin increases cardiac contractility via protein kinase Cε- and extracellular signal-regulated kinase-dependent mechanisms.

PLoS ONE, 2014
BackgroundApelin, the endogenous ligand for the G protein-coupled apelin receptor, is an important regulator of the cardiovascular homoeostasis.
Ábel Perjés, Réka Skoumal, Olli Tenhunen, Attila Kónyi, Mihály Simon, Iván G Horváth, Risto Kerkelä, Heikki Ruskoaho, István Szokodi   +8 more
doaj   +1 more source

Apelin-13 enhances arcuate POMC neuron activity via inhibiting M-current.

PLoS ONE, 2015
The hypothalamus is a key element of the neural circuits that control energy homeostasis. Specific neuronal populations within the hypothalamus are sensitive to a variety of homeostatic indicators such as circulating nutrient levels and hormones that ...
Dong Kun Lee, Jae Hoon Jeong, Seunghoon Oh, Young-Hwan Jo   +3 more
doaj   +1 more source

Exploring Autophagy Inducing Molecules: Targeting Diverse Pathways in Alzheimer's Disease Management

Medicinal Research Reviews, Volume 46, Issue 1, Page 272-298, January 2026.
ABSTRACT Neurodegenerative disorders, including Alzheimer's disease (AD), impose a significant burden on society due to their progressive nature and the associated healthcare costs. Autophagy, a vital cellular degradation process, has emerged as a promising therapeutic target in these disorders.
Baljinder Singh, Shubham Mahajan, Sadikalmahdi Abdella, Rehan Khan, Sanjay Garg   +4 more
wiley   +1 more source

Anti-Apoptotic Effect of Apelin in Human Placenta: Studies on BeWo Cells and Villous Explants from Third-Trimester Human Pregnancy [PDF]

, 2021
Ewa Mlyczyńska, Małgorzata Myszka, Patrycja Kurowska, Monika Dawid, Tomasz Milewicz, Marta Bałajewicz‐Nowak, Paweł Kowalczyk, Agnieszka Rak   +7 more
openalex   +1 more source

Integrative Bioinformatics Reveals Novel Molecular Mechanisms and Therapeutic Targets in Acute Myeloid Leukaemia

Journal of Cellular and Molecular Medicine, Volume 30, Issue 1, January 2026.
ABSTRACT Acute myeloid leukaemia (AML) is a genetically heterogeneous malignancy associated with poor prognosis and limited treatment options. To identify molecular programs conserved across AML subtypes and perturbations, we analysed three RNA sequencing datasets that captured venetoclax treatment under metabolic stress and the knockdown of chromatin ...
Muteb Muyey Daniel, Gradel Holel Andwey
wiley   +1 more source

Apelin ameliorates sepsis-induced myocardial dysfunction via inhibition of NLRP3-mediated pyroptosis of cardiomyocytes

Heliyon
Sepsis-induced myocardial dysfunction (SMD) is the major cause of death in sepsis. Nucleotide-binding oligomerization domain-like receptor family pyrin domain containing 3 (NLRP3)-mediated pyroptosis contributes to the occurrence and development of SMD ...
Zhi Cao, Weifeng Li, Zhuang Shao, Xinqiang Liu, Yi Zeng, Peijun Lin, Chuangqiang Lin, Yuechu Zhao, Ting Li, Zichao Zhao, Xin Li, Yuelin Zhang, Bei Hu   +12 more
doaj   +1 more source

Apelin protects against NMDA-induced retinal neuronal death via an APJ receptor by activating Akt and ERK1/2, and suppressing TNF-α expression in mice

Journal of Pharmacological Sciences, 2017
Glutamate excitotoxicity mediated by N-methyl-d-aspartate (NMDA) receptors is an important cause of retinal ganglion cell death in glaucoma. To elucidate whether apelin protects against retinal neuronal cell death, we examined protective effects of ...
Yuki Ishimaru, Akihide Sumino, Daiki Kajioka, Fumiya Shibagaki, Akiko Yamamuro, Yasuhiro Yoshioka, Sadaaki Maeda   +6 more
doaj   +1 more source