Results 11 to 20 of about 23,711 (313)

On Methods for the Measurement of the Apelin Receptor Ligand Apelin

Scientific Reports, 2022
Apelin exists in many isoforms, both in the circulation and in specific tissues. Apelin peptides have a short half-life but preservation before measurement is scarcely studied.
Peter Janssens, Henriette de Loor, Jean-Paul Decuypere, Rudi Vennekens, Catherine Llorens-Cortes, Djalila Mekahli, Bert Bammens   +6 more
doaj   +4 more sources

Short-Term Hemodynamic Effects of Apelin in Patients With Pulmonary Arterial Hypertension [PDF]

JACC: Basic to Translational Science, 2018
Summary: Apelin agonism causes systemic vasodilatation and increased cardiac contractility in humans, and improves pulmonary arterial hypertension (PAH) in animal models. Here, the authors examined the short-term pulmonary hemodynamic effects of systemic
Lauren Brash, MD, Gareth D. Barnes, MD, Melanie J. Brewis, MD, A. Colin Church, MD, Simon J. Gibbs, MD, Luke S.G.E. Howard, MD, Geeshath Jayasekera, MBChB, Martin K. Johnson, MD, Neil McGlinchey, MBChB, Joelle Onorato, PhD, Joanne Simpson, MD, Colin Stirrat, MD, Stephen Thomson, MBChB, Geoffrey Watson, MD, Martin R. Wilkins, MD, Carrie Xu, MS, David J. Welsh, PhD, David E. Newby, MD, Andrew J. Peacock, MD   +18 more
doaj   +6 more sources

Apelin is a novel islet peptide [PDF]

Regulatory Peptides, 2010
Apelin, a recently discovered peptide with wide tissue distribution, regulates feeding behavior, improves glucose utilization, and inhibits insulin secretion. We examined whether apelin is expressed in human islets, as well as in normal and type 2 diabetic (T2D) animal islets.
Camilla Ringström, Marloes Dekker Nitert, Hedvig Bennet, Malin Fex, Philippe Valet, Jens F. Rehfeld, Lennart Friis‐Hansen, Nils Wierup   +7 more
openalex   +8 more sources

Targeting the apelin system for the treatment of cardiovascular diseases

Cardiovascular Research, 2023
Cardiovascular disease is the leading cause of death worldwide. Its prevalence is rising due to ageing populations and the increasing incidence of diseases such as chronic kidney disease, obesity, and diabetes that are associated with elevated ...
Fiona A. Chapman, J. Maguire, David E. Newby, A. Davenport, N. Dhaun   +4 more
semanticscholar   +1 more source

Toddler: An Embryonic Signal That Promotes Cell Movement via Apelin Receptors [PDF]

Science, 2014
Andrea Pauli, Eivind Valen, Guo-Liang Chew   +2 more
exaly   +2 more sources

Apelin and its Receptor: An Overview [PDF]

Journal of Clinical and Diagnostic Research, 2019
Apelin protein is an endogenous ligand of Apelin Receptor (APJ). APJ is a member of G-protein coupled receptor family. Both apelin and its receptor express extensively in the human body.
Rajeev Gandham, ME Sumathi, CD Dayanand, SR Sheela, P Kiranmayee   +4 more
doaj   +1 more source

The Role of Apelin–APJ System in Diabetes and Obesity

Frontiers in Endocrinology, 2022
Nowadays, diabetes and obesity are two main health-threatening metabolic disorders in the world, which increase the risk for many chronic diseases. Apelin, a peptide hormone, exerts its effect by binding with angiotensin II protein J receptor (APJ) and ...
Cheng Li, Hongna Cheng, B. Adhikari, Shudong Wang, Na Yang, Wenyun Liu, Jian Sun, Yonggang Wang   +7 more
semanticscholar   +1 more source

The Effects of Apelin and Elabela Ligands on Apelin Receptor Distinct Signaling Profiles [PDF]

Frontiers in Pharmacology, 2021
Apelin and Elabela are endogenous peptide ligands for Apelin receptor (APJ), a widely expressed G protein-coupled receptor. They constitute a spatiotemporal dual ligand system to control APJ signal transduction and function. We investigated the effects of Apelin-13, pGlu1-apelin-13, Apelin-17, Apelin-36, Elabela-21 and Elabela-32 peptides on APJ signal
Jing Chen, Jing Chen, Rumin Zhang, Qinqin Wang, Bingyuan Ji, Lei Wan, Huiyun Wang, Chunmei Wang, Xiaoyu Chen, Yunlu Jiang, Maocai Yan, Bo Dong   +11 more
openaire   +4 more sources

Apelin Prevents and Alleviates Crystalline Silica-induced Pulmonary Fibrosis via Inhibiting Transforming Growth Factor Beta 1-triggered Fibroblast Activation

International Journal on Biological Sciences, 2023
Silicosis is a common and ultimately fatal occupational disease, yet the limited therapeutic option remains the major clinical challenge. Apelin, an endogenous ligand of the G-protein-coupled receptor (APJ), is abundantly expressed in diverse organs. The
Jian-Xin Shen, Jiayin Feng, Zhijia Wu, Y. Ou, Qing Zhang, Qiying Nong, Qifeng Wu, Cong Li, Xiaohui Tan, M.‐W. Ye, Zhongxiang Gao, Ying Zhang, Weihui Liang, Lihua Xia, Yi-ping Qin, Yongshun Huang, N. Zhao, Shijie Hu   +17 more
semanticscholar   +1 more source

Apelin as a Potential Regulator of Peak Athletic Performance

International Journal of Molecular Sciences, 2023
Apelin, as a cardiokine/myokine, is emerging as an important regulator of cardiac and skeletal muscle homeostasis. Loss of apelin signaling results in premature cardiac aging and sarcopenia.
R. Ligetvári, I. Szokodi, G. Far, É. Csöndör, Ákos Móra, Z. Komka, M. Tóth, A. Oláh, P. Ács   +8 more
semanticscholar   +1 more source