Results 11 to 20 of about 15,683 (226)

Investigation of the relationship between uterine artery Doppler diastolic notching and serum apelin-13 and apelin-36 concentrations between the 11^th and 14^th weeks of pregnancy: a case-control study. [PDF]

Pan Afr Med J
Acar FD, Kale İ, Muhcu M.
europepmc   +2 more sources

Structure-guided discovery of a single-domain antibody agonist against human apelin receptor [PDF]

Science Advances, 2020
Yanbin, Xianqiang Song, Xun Li
exaly   +2 more sources

Apelin and its ratio to lipid factors are associated with cardiovascular diseases: A systematic review and meta-analysis

PLoS ONE, 2022
Background The present systematic review and meta-analysis aimed to ascertain if the circulating levels of apelin, as an important regulator of the cardiovascular homeostasis, differ in patients with cardiovascular diseases (CVDs) and controls. Methods A
Hamed Akbari, Mahnaz Hosseini-Bensenjan, Sarvenaz Salahi, Fatemeh Moazzen, Hamid Aria, Alireza Manafi, Saeed Hosseini, Maryam Niknam, Gholamreza Asadikaram   +8 more
doaj   +3 more sources

Targeting the apelin system for the treatment of cardiovascular diseases

Cardiovascular Research, 2023
Cardiovascular disease is the leading cause of death worldwide. Its prevalence is rising due to ageing populations and the increasing incidence of diseases such as chronic kidney disease, obesity, and diabetes that are associated with elevated ...
Fiona A. Chapman, J. Maguire, David E. Newby, A. Davenport, N. Dhaun   +4 more
semanticscholar   +1 more source

Apelin and its Receptor: An Overview [PDF]

Journal of Clinical and Diagnostic Research, 2019
Apelin protein is an endogenous ligand of Apelin Receptor (APJ). APJ is a member of G-protein coupled receptor family. Both apelin and its receptor express extensively in the human body.
Rajeev Gandham, ME Sumathi, CD Dayanand, SR Sheela, P Kiranmayee   +4 more
doaj   +1 more source

Myocardial injection of apelin-overexpressing bone marrow cells improves cardiac repair via upregulation of Sirt3 after myocardial infarction. [PDF]

PLoS ONE, 2013
Our previous study shows that treatment with apelin increases bone marrow cells (BMCs) recruitment and promotes cardiac repair after myocardial infarction (MI).
Lanfang Li, Heng Zeng, Xuwei Hou, Xiaochen He, Jian-Xiong Chen   +4 more
doaj   +1 more source

ALK1 controls hepatic vessel formation, angiodiversity, and angiocrine functions in hereditary hemorrhagic telangiectasia of the liver

Hepatology, EarlyView., 2022
Hepatic endothelial Alk1 signaling protects from development of vascular malformations while maintaining organ‐specific endothelial differentiation and angiocrine portmanteau of the names Wingless and Int‐1 signaling. Abstract Background and Aims In hereditary hemorrhagic telangiectasia (HHT), severe liver vascular malformations are associated with ...
Christian David Schmid, Victor Olsavszky, Manuel Reinhart, Vanessa Weyer, Felix A. Trogisch, Carsten Sticht, Manuel Winkler, Sina W. Kürschner, Johannes Hoffmann, Roxana Ola, Theresa Staniczek, Joerg Heineke, Beate K. Straub, Jens Mittler, Kai Schledzewski, Peter ten Dijke, Karsten Richter, Steven Dooley, Cyrill Géraud, Sergij Goerdt, Philipp‐Sebastian Koch   +20 more
wiley   +1 more source

Apelin-13 Protects Neurons by Attenuating Early-Stage Postspinal Cord Injury Apoptosis In Vitro

Brain Sciences, 2022
Apelin is a 77-amino-acid peptide that is an endogenous ligand for the G protein-coupled receptor APJ (Apelin receptor, APJ). Apelin-13, as the most bioactive affinity fragment of apelin, plays a role in energy metabolism, myocardial ischemia-reperfusion
Taotao Lin, Yujie Zhao, Shengyu Guo, Zhengru Wu, Wenwen Li, Rongcan Wu, Zhenyu Wang, Wenge Liu   +7 more
doaj   +1 more source

Tumor endothelial cell-specific drug delivery system using apelin-conjugated liposomes. [PDF]

PLoS ONE, 2013
BACKGROUND: A drug delivery system specifically targeting endothelial cells (ECs) in tumors is required to prevent normal blood vessels from being damaged by angiogenesis inhibitors.
Hiroki Kawahara, Hisamichi Naito, Kazuhiro Takara, Taku Wakabayashi, Hiroyasu Kidoya, Nobuyuki Takakura   +5 more
doaj   +1 more source

Endothelial cell-derived Apelin inhibits tumor growth by altering immune cell localization

Scientific Reports, 2021
The Apelin/APJ signalling pathway, involved in multiple physiological and pathological processes, has been attracting increasing interest recently. In our previous study, Apelin overexpression in colon26 tumor cells suppressed tumor growth by inducing ...
Liuying Hu, Yumiko Hayashi, Hiroyasu Kidoya, Nobuyuki Takakura   +3 more
doaj   +1 more source