Results 21 to 30 of about 15,683 (226)
Apelin-13 alleviates contrast-induced acute kidney injury by inhibiting endoplasmic reticulum stress
Renal Failure, 2023 Contrast-induced acute kidney injury (CI-AKI) is a severe complication associated with significant morbidity and mortality, and effective therapeutic strategies are still lacking.
Qian Liu +9 more
semanticscholar +1 more source
Frontiers in Neuroscience, 2020 Apelin is an endogenous neuropeptide, which has wide distribution in central nervous system and peripheral tissues. Pyroglutamyl apelin-13 [(pyr)apelin-13] is the major apelin isoform in human plasma.
Shuangyu Lv +6 more
doaj +1 more source
Frontiers in Cardiovascular Medicine, 2022 BackgroundRecent studies suggest apelin has multiple protective effects in some cardiovascular diseases. However, there are few data concerning apelin levels in patients with obstructive hypertrophic cardiomyopathy (OHCM) or the relationship between ...
Chengzhi Yang +5 more
doaj +1 more source
Pharmaceutics, 2023 In-hospital mortality in patients with ST-segment elevation myocardial infarction (STEMI) is 5–6%. Consequently, it is necessary to develop fundamentally novel drugs capable of reducing mortality in patients with acute myocardial infarction.
S. Popov +8 more
semanticscholar +1 more source
The role of the host—Neutrophil biology
Periodontology 2000, EarlyView., 2023 Abstract Neutrophilic polymorphonuclear leukocytes (neutrophils) are myeloid cells packed with lysosomal granules (hence also called granulocytes) that contain a formidable antimicrobial arsenal. They are terminally differentiated cells that play a critical role in acute and chronic inflammation, as well as in the resolution of inflammation and wound ...
Iain L. C. Chapple +4 more
wiley +1 more source
International Journal on Biological Sciences, 2023 Silicosis is a common and ultimately fatal occupational disease, yet the limited therapeutic option remains the major clinical challenge. Apelin, an endogenous ligand of the G-protein-coupled receptor (APJ), is abundantly expressed in diverse organs. The
Jian-Xin Shen +17 more
semanticscholar +1 more source
Apelin as a Potential Regulator of Peak Athletic Performance
International Journal of Molecular Sciences, 2023 Apelin, as a cardiokine/myokine, is emerging as an important regulator of cardiac and skeletal muscle homeostasis. Loss of apelin signaling results in premature cardiac aging and sarcopenia.
R. Ligetvári +8 more
semanticscholar +1 more source
Cureus, 2023 Introduction: Type 2 diabetes mellitus (T2DM) is a chronic disorder characterized by persistent hyperglycemia. Chronic hyperglycemia in diabetes mellitus can cause microvascular and macrovascular complications. Obesity is a major risk factor contributing
Chinmaya Mund +5 more
semanticscholar +1 more source
Promoting effects of the adipokine, apelin, on diabetic nephropathy. [PDF]
PLoS ONE, 2013 Angiogenesis, increased glomerular permeability, and albuminuria are thought to contribute to the progression of diabetic nephropathy (DN). Apelin receptor (APLNR) and the endogenous ligand of APLNR, apelin, induce the sprouting of endothelial cells in ...
Bao-hai Zhang +4 more
doaj +1 more source
Beneficial effects of Apelin-13 on metabolic diseases and exercise
Frontiers in Endocrinology, 2023 Apelin, a novel endogenous ligand of the G-protein-coupled receptor APJ, is encoded by the APLN gene and can be hydrolyzed into multiple subtypes, with Apelin-13 being one of the most active subtypes of the Apelin family.
Rui-ming Wen +4 more
semanticscholar +1 more source