Results 21 to 30 of about 23,711 (313)

ALK1 controls hepatic vessel formation, angiodiversity, and angiocrine functions in hereditary hemorrhagic telangiectasia of the liver

Hepatology, EarlyView., 2022
Hepatic endothelial Alk1 signaling protects from development of vascular malformations while maintaining organ‐specific endothelial differentiation and angiocrine portmanteau of the names Wingless and Int‐1 signaling. Abstract Background and Aims In hereditary hemorrhagic telangiectasia (HHT), severe liver vascular malformations are associated with ...
Christian David Schmid, Victor Olsavszky, Manuel Reinhart, Vanessa Weyer, Felix A. Trogisch, Carsten Sticht, Manuel Winkler, Sina W. Kürschner, Johannes Hoffmann, Roxana Ola, Theresa Staniczek, Joerg Heineke, Beate K. Straub, Jens Mittler, Kai Schledzewski, Peter ten Dijke, Karsten Richter, Steven Dooley, Cyrill Géraud, Sergij Goerdt, Philipp‐Sebastian Koch   +20 more
wiley   +1 more source

Apelin-13 alleviates contrast-induced acute kidney injury by inhibiting endoplasmic reticulum stress

Renal Failure, 2023
Contrast-induced acute kidney injury (CI-AKI) is a severe complication associated with significant morbidity and mortality, and effective therapeutic strategies are still lacking.
Qian Liu, S. Duan, Lin Wang, Xiao Luo, Hong-Shen Wang, Ying-Hao Deng, Xi Wu, Ting Wu, Ping Yan and, Yi-Xin Kang   +9 more
semanticscholar   +1 more source

Apelin and Pulmonary Hypertension [PDF]

Pulmonary Circulation, 2011
Pulmonary arterial hypertension (PAH) is a devastating disease characterized by pulmonary vasoconstriction, pulmonary arterial remodeling, abnormal angiogenesis and impaired right ventricular function. Despite progress in pharmacological therapy, there is still no cure for PAH.
Andersen, Charlotte Uggerhøj, Hilberg, Ole, Mellemkjær, Søren, Nielsen-Kudsk, Jens E, Simonsen, U   +4 more
openaire   +3 more sources

Tumor endothelial cell-specific drug delivery system using apelin-conjugated liposomes. [PDF]

PLoS ONE, 2013
BACKGROUND: A drug delivery system specifically targeting endothelial cells (ECs) in tumors is required to prevent normal blood vessels from being damaged by angiogenesis inhibitors.
Hiroki Kawahara, Hisamichi Naito, Kazuhiro Takara, Taku Wakabayashi, Hiroyasu Kidoya, Nobuyuki Takakura   +5 more
doaj   +1 more source

Apelin-13 Protects Neurons by Attenuating Early-Stage Postspinal Cord Injury Apoptosis In Vitro

Brain Sciences, 2022
Apelin is a 77-amino-acid peptide that is an endogenous ligand for the G protein-coupled receptor APJ (Apelin receptor, APJ). Apelin-13, as the most bioactive affinity fragment of apelin, plays a role in energy metabolism, myocardial ischemia-reperfusion
Taotao Lin, Yujie Zhao, Shengyu Guo, Zhengru Wu, Wenwen Li, Rongcan Wu, Zhenyu Wang, Wenge Liu   +7 more
doaj   +1 more source

Study of Serum Apelin and Insulin Resistance in Type 2 Diabetes Mellitus Patients With or Without Obesity

Cureus, 2023
Introduction: Type 2 diabetes mellitus (T2DM) is a chronic disorder characterized by persistent hyperglycemia. Chronic hyperglycemia in diabetes mellitus can cause microvascular and macrovascular complications. Obesity is a major risk factor contributing
Chinmaya Mund, Chetan K Kellellu, R. Rattan, Srikrushna Mahapatra, A. A. Lamare, S. Jena   +5 more
semanticscholar   +1 more source

Endothelial cell-derived Apelin inhibits tumor growth by altering immune cell localization

Scientific Reports, 2021
The Apelin/APJ signalling pathway, involved in multiple physiological and pathological processes, has been attracting increasing interest recently. In our previous study, Apelin overexpression in colon26 tumor cells suppressed tumor growth by inducing ...
Liuying Hu, Yumiko Hayashi, Hiroyasu Kidoya, Nobuyuki Takakura   +3 more
doaj   +1 more source

The Interaction of Apelin and FGFR1 Ameliorated the Kidney Fibrosis through Suppression of TGFβ-Induced Endothelial-to-Mesenchymal Transition

Oxidative Medicine and Cellular Longevity, 2023
Both epithelial-to-mesenchymal (EMT) and endothelial-to-mesenchymal (EndMT) transitions have shown to contribute to the development and progression of kidney fibrosis.
Rongfen Gao, Yumin Wu, Qiang Yang, Liangdong Chen, Jiwei Chen, Boyong Wang, Zeming Liu, Juan Jin, Jinpeng Li, Gaosong Wu   +9 more
semanticscholar   +1 more source

Intravenous Administration of Pyroglutamyl Apelin-13 Alleviates Murine Inflammatory Pain via the Kappa Opioid Receptor

Frontiers in Neuroscience, 2020
Apelin is an endogenous neuropeptide, which has wide distribution in central nervous system and peripheral tissues. Pyroglutamyl apelin-13 [(pyr)apelin-13] is the major apelin isoform in human plasma.
Shuangyu Lv, Xiaomei Zhang, Yu Feng, Yuchen Zhou, Binbin Cui, Yanjie Yang, Xinchun Wang   +6 more
doaj   +1 more source

Significance and Determinants of Plasma Apelin in Patients With Obstructive Hypertrophic Cardiomyopathy

Frontiers in Cardiovascular Medicine, 2022
BackgroundRecent studies suggest apelin has multiple protective effects in some cardiovascular diseases. However, there are few data concerning apelin levels in patients with obstructive hypertrophic cardiomyopathy (OHCM) or the relationship between ...
Chengzhi Yang, Changlin Zhang, Ruofei Jia, Shubin Qiao, Jiansong Yuan, Zening Jin   +5 more
doaj   +1 more source