Results 31 to 40 of about 23,711 (313)

Beneficial effects of Apelin-13 on metabolic diseases and exercise

Frontiers in Endocrinology, 2023
Apelin, a novel endogenous ligand of the G-protein-coupled receptor APJ, is encoded by the APLN gene and can be hydrolyzed into multiple subtypes, with Apelin-13 being one of the most active subtypes of the Apelin family.
Rui-ming Wen, Ruiqi Huang, Ke Xu, Yang Cheng, Xuejie Yi   +4 more
semanticscholar   +1 more source

Apelin Is a Prototype of Novel Drugs for the Treatment of Acute Myocardial Infarction and Adverse Myocardial Remodeling

Pharmaceutics, 2023
In-hospital mortality in patients with ST-segment elevation myocardial infarction (STEMI) is 5–6%. Consequently, it is necessary to develop fundamentally novel drugs capable of reducing mortality in patients with acute myocardial infarction.
S. Popov, L. Maslov, A. Mukhomedzyanov, B. Kurbatov, A. Gorbunov, Michail Kilin, Viacheslav N. Azev, M. S. Khlestkina, G. Z. Sufianova   +8 more
semanticscholar   +1 more source

The role of the host—Neutrophil biology

Periodontology 2000, EarlyView., 2023
Abstract Neutrophilic polymorphonuclear leukocytes (neutrophils) are myeloid cells packed with lysosomal granules (hence also called granulocytes) that contain a formidable antimicrobial arsenal. They are terminally differentiated cells that play a critical role in acute and chronic inflammation, as well as in the resolution of inflammation and wound ...
Iain L. C. Chapple, Josefine Hirschfeld, Alpdogan Kantarci, Asaf Wilensky, Lior Shapira   +4 more
wiley   +1 more source

Apelin and energy metabolism [PDF]

Frontiers in Physiology, 2015
A wide range of adipokines identified over the past years has allowed considering the white adipose tissue as a secretory organ closely integrated into overall physiological and metabolic control. Apelin, a ubiquitously expressed peptide was known to exert different physiological effects mainly on the cardiovascular system and the regulation of fluid ...
C. Bertrand, C. Bertrand, Isabelle Castan-Laurell, Isabelle Castan-Laurell, Philippe Valet, Philippe Valet   +5 more
openaire   +3 more sources

APELIN IN HEART FAILURE

Wiadomości Lekarskie, 2022
Apelin is a biologically active protein encoded by the APLN gene. It was first isolated in 1998 as a ligand for the APJ receptor. It exists in several isoforms differing in polypeptide chain length and biological activity. It is secreted by white adipose tissue, and its expression has been identified in many body tissues, including the cardiovascular ...
Kamil, Marczewski, Natalia, Gospodarczyk, Alicja, Gospodarczyk, Michał, Widuch, Michał, Tkocz   +4 more
openaire   +3 more sources

Structural Basis for Apelin Control of the Human Apelin Receptor [PDF]

Structure, 2017
Apelin receptor (APJR) is a key regulator of human cardiovascular function and is activated by two different endogenous peptide ligands, apelin and Elabela, each with different isoforms diversified by length and amino acid sequence. Here we report the 2.6-Å resolution crystal structure of human APJR in complex with a designed 17-amino-acid apelin ...
Wenge Zhong, Fei Xu, Mingqiang Zhang, Qing Zhang, E. Allen Sickmier, Yang Yue, Raymond C. Stevens, Suwen Zhao, Gye Won Han, Yuqing Shen, Chao Li, Yunpeng Song, Liaoyuan A. Hu, Xiaochuan Ma, Yingli Ma, Xun Li, Michael A. Hanson, Yanbin Ma, Gayathri Swaminath, Qingtong Zhou   +19 more
openaire   +3 more sources

Altered Gut Microbiota and Endocannabinoid System Tone in Obese and Diabetic Leptin-Resistant Mice: Impact on Apelin Regulation in Adipose Tissue

Frontiers in Microbiology, 2011
Lucie Geurts, Vladimir Lazarevic, Muriel Derrien   +2 more
exaly   +2 more sources

Apelin-13 Attenuates Lipopolysaccharide-Induced Inflammatory Responses and Acute Lung Injury by Regulating PFKFB3-Driven Glycolysis Induced by NOX4-Dependent ROS

Journal of Inflammation Research, 2022
Purpose Acute lung injury (ALI) is a life-threatening condition with limited therapeutic options. Macrophage inflammation plays a key role in the development of ALI. Abnormal glycolysis of macrophages contributes to the inflammatory response.
Yafei Yuan, W. Wang, Yue Zhang, Qiaohui Hong, Wenhui Huang, Lijuan Li, Zhan-Li Xie, Yixin Chen, Xu Li, Y. Meng   +9 more
semanticscholar   +1 more source

Apelin Rejuvenates Aged Human Mesenchymal Stem Cells by Regulating Autophagy and Improves Cardiac Protection After Infarction

Frontiers in Cell and Developmental Biology, 2021
The protective effects of mesenchymal stem cell (MSC)-based therapy for myocardial infarction (MI) are largely hampered as they age. Apelin is an endogenous ligand of its receptor APJ and plays an essential role in regulating multiple biological ...
Hao Zhang, Hao Zhang, Chengling Zhao, Guojun Jiang, Bei Hu, Huifeng Zheng, Yimei Hong, Zhen Cui, Linli Shi, Xin Li, Fang Lin, Fang Lin, Yue Ding, Lu Wei, Mimi Li, Xiaoting Liang, Xiaoting Liang, Yuelin Zhang, Yuelin Zhang   +18 more
doaj   +1 more source

Fish Feed Intake, Feeding Behavior, and the Physiological Response of Apelin to Fasting and Refeeding

Frontiers in Endocrinology, 2021
Feed is one of the most important external signals in fish that stimulates its feeding behavior and growth. The intake of feed is the main factor determining efficiency and cost, maximizing production efficiency in a fish farming firm.
D. Assan, Yanlin Huang, U. Mustapha, Mercy Nabila Addah, Guangli Li, Huapu Chen   +5 more
semanticscholar   +1 more source