Results 31 to 40 of about 15,683 (226)

Prognostic Value of Combining Apelin-12 and Estimated Glomerular Filtration Rate in Patients with ST-Segment Elevation Myocardial Infarction

Journal of Interventional Cardiology, 2022
Background. Apelin-12 and estimated glomerular filtration rate (eGFR) are considered prognostic factors for ST-segment elevation myocardial infarction (STEMI).
Yue Liu, Huasong Xia, Meng Li, Yi Chen, Yanqing Wu   +4 more
doaj   +1 more source

The Role of Apelin–APJ System in Diabetes and Obesity

Frontiers in Endocrinology, 2022
Nowadays, diabetes and obesity are two main health-threatening metabolic disorders in the world, which increase the risk for many chronic diseases. Apelin, a peptide hormone, exerts its effect by binding with angiotensin II protein J receptor (APJ) and ...
Cheng Li, Hongna Cheng, B. Adhikari, Shudong Wang, Na Yang, Wenyun Liu, Jian Sun, Yonggang Wang   +7 more
semanticscholar   +1 more source

Apelin promotes blood and lymph vessel formation and the growth of melanoma lung metastasis

Scientific Reports, 2021
Apelin, a ligand of the APJ receptor, is overexpressed in several human cancers and plays an important role in tumor angiogenesis and growth in various experimental systems.
Judit Berta, Szilvia Török, Júlia Tárnoki-Zách, Orsolya Drozdovszky, József Tóvári, Sándor Paku, Ildikó Kovács, András Czirók, Bernard Masri, Zsolt Megyesfalvi, Henriett Oskolás, Johan Malm, Christian Ingvar, György Markó-Varga, Balázs Döme, Viktória László   +15 more
doaj   +1 more source

The Interaction of Apelin and FGFR1 Ameliorated the Kidney Fibrosis through Suppression of TGFβ-Induced Endothelial-to-Mesenchymal Transition

Oxidative Medicine and Cellular Longevity, 2023
Both epithelial-to-mesenchymal (EMT) and endothelial-to-mesenchymal (EndMT) transitions have shown to contribute to the development and progression of kidney fibrosis.
Rongfen Gao, Yumin Wu, Qiang Yang, Liangdong Chen, Jiwei Chen, Boyong Wang, Zeming Liu, Juan Jin, Jinpeng Li, Gaosong Wu   +9 more
semanticscholar   +1 more source

Apelin Rejuvenates Aged Human Mesenchymal Stem Cells by Regulating Autophagy and Improves Cardiac Protection After Infarction

Frontiers in Cell and Developmental Biology, 2021
The protective effects of mesenchymal stem cell (MSC)-based therapy for myocardial infarction (MI) are largely hampered as they age. Apelin is an endogenous ligand of its receptor APJ and plays an essential role in regulating multiple biological ...
Hao Zhang, Hao Zhang, Chengling Zhao, Guojun Jiang, Bei Hu, Huifeng Zheng, Yimei Hong, Zhen Cui, Linli Shi, Xin Li, Fang Lin, Fang Lin, Yue Ding, Lu Wei, Mimi Li, Xiaoting Liang, Xiaoting Liang, Yuelin Zhang, Yuelin Zhang   +18 more
doaj   +1 more source

Astrocyte-vascular interplay in Alzheimer's disease pathology: Novel insights into stage-specific biomarkers and therapeutic targets. [PDF]

Alzheimers Dement
Abstract INTRODUCTION We examined how neurovascular and astrocytic response alter cognition in Alzheimer's disease (AD). METHODS Cognitive scores, biomarkers of AD and astrocytic activation, vascular factors, and brain structure data from 693 Alzheimer's Disease Neuroimaging Initiative (ADNI) participants were analyzed using analysis of covariance ...
Sheng Z, Chen Y, Chen M, Liang S, Wang J, Chen Y, Li R, Xia B, Gou K, Liu S, Alzheimer's Disease Neuroimaging Initiative, Yu W, Lü Y.   +12 more
europepmc   +2 more sources

Effect of apelin on cardiac contractility in acute reno-vascular hypertension: The role of apelin receptor and kappa opioid receptor heterodimerization [PDF]

Iranian Journal of Basic Medical Sciences, 2018
Objective(s): Apelin/APJ system plays an important role in the regulation of myocardial contractility (MC) and blood pressure. Opioid receptors (OPRs) are also important cardiovascular regulators and exert many of their effects through modulating the ...
Mahboobeh Yeganeh-Hajahmadi, Hamid Najafipour, Farzaneh Rostamzadeh, saeed Esmaeili Mahani, Siavash Joukar   +4 more
doaj   +1 more source

The Role of Apelin/Apelin Receptor in Energy Metabolism and Water Homeostasis: A Comprehensive Narrative Review

Frontiers in Physiology, 2021
The apelin receptor (APJ) is a member of the family A of G-protein-coupled receptors (GPCRs) and is involved in range of physiological and pathological functions, including fluid homeostasis, anxiety, and depression, as well as cardiovascular and ...
Gong Hu, Zhen Wang, Rumin Zhang, Wenping Sun, Xiaoyu Chen   +4 more
semanticscholar   +1 more source

Low Dose of Apelin-36 Attenuates ER Stress-Associated Apoptosis in Rats with Ischemic Stroke

Frontiers in Neurology, 2017
Cerebral ischemia/reperfusion (I/R) injury-induced cellular apoptosis contributes to neuronal death in ischemic stroke, while endoplasmic reticulum stress (ERS) and subsequently triggered unfolded protein response (UPR) are the major mechanisms of ...
Jian Qiu, Jian Qiu, Xin Wang, Xin Wang, Fei Wu, Lei Wan, Baohua Cheng, Yili Wu, Yili Wu, Yili Wu, Bo Bai, Bo Bai, Bo Bai   +12 more
doaj   +1 more source

Fish Feed Intake, Feeding Behavior, and the Physiological Response of Apelin to Fasting and Refeeding

Frontiers in Endocrinology, 2021
Feed is one of the most important external signals in fish that stimulates its feeding behavior and growth. The intake of feed is the main factor determining efficiency and cost, maximizing production efficiency in a fish farming firm.
D. Assan, Yanlin Huang, U. Mustapha, Mercy Nabila Addah, Guangli Li, Huapu Chen   +5 more
semanticscholar   +1 more source