Results 61 to 70 of about 23,711 (313)
Mediators of Inflammation, 2022 Methods The current investigation was conducted in a single-blind and quasiexperimental fashion. Sixty overweight and obese men (BMI > 25) ranging in age from 30 to 55 years were purposefully selected and randomly assigned to one of four groups: training
Malekaneh Mohammad +5 more
semanticscholar +1 more source
Cheminformatics Research at the Unilever Centre for Molecular Science Informatics Cambridge. [PDF]
, 2015 The Centre for Molecular Informatics, formerly Unilever Centre for Molecular Science Informatics (UCMSI), at the University of Cambridge is a world-leading driving force in the field of cheminformatics.
core +2 more sources
ASN Neuro, 2015 Apelin is a peptide originally isolated from bovine stomach tissue extracts and identified as an endogenous ligand of the APJ receptor; recent work showed that apelin ameliorates the ischemic injury in the heart and the brain.
Dongdong Chen +4 more
doaj +1 more source
Long-term treatment with acylated analogues of apelin-13 amide ameliorates diabetes and improves lipid profile of high-fat fed mice. [PDF]
PLoS ONE, 2018 Previous studies have shown that modified apelin analogues exhibited enzyme resistance in plasma and improved circulating half-life compared to apelin-13.
Finbarr P M O'Harte +3 more
doaj +1 more source
International Journal of Molecular Sciences, 2022 Despite decades of effort in understanding pancreatic ductal adenocarcinoma (PDAC), there is still a lack of innovative targeted therapies for this devastating disease. Herein, we report the expression of apelin and its receptor, APJ, in human pancreatic
Carline Chaves-Almagro +20 more
semanticscholar +1 more source
Possible roles of exercise and apelin against pregnancy complications
Frontiers in Endocrinology, 2022 The prevalence of maternal obesity during pregnancy is associated with the risk of gestational diabetes, preeclampsia, and cardiomyopathy. Environmental factors such as active lifestyles and apelin may lead to beneficial changes.
Hamed Alizadeh Pahlavani
semanticscholar +1 more source
Agonist-induced internalization and desensitization of the apelin receptor [PDF]
, 2016 Apelin acts via the G protein-coupled apelin receptor (APJ) to mediate effects on cardiovascular and fluid homeostasis. G protein-coupled receptor (GPCR) trafficking has an important role in the regulation of receptor signalling pathways and cellular ...
Lolait, Stephen J. +4 more
core +1 more source
Inhibition of the apelin/apelin receptor axis decreases cholangiocarcinoma growth [PDF]
Cancer Letters, 2017 Cholangiocarcinoma (CCA) is a malignancy of the biliary epithelium that is associated with low five-year survival. The apelin receptor (APLNR), which is activated by the apelin peptide, has not been studied in CCA. The purpose of this study is to determine if inhibition of the apelin/APLNR axis can inhibit CCA growth.Immunohistochemistry, rtPCR ...
Julie Venter +13 more
openaire +3 more sources
The complex interactions between obesity, metabolism and the brain [PDF]
, 2019 Obesity is increasing at unprecedented levels globally, and the overall impact ofobesity on the various organ systems of the body is only beginning to be fullyappreciated. Because of the myriad of direct and indirect effects of obesity causingdysfunction
Keller, Jeffrey Neil +1 more
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Effects of apelin on the cardiovascular system [PDF]
Heart Failure Reviews, 2015 Apelin is an endogenous peptide acting on the APJ receptor. It consists of several isoforms characterized by different numbers of amino acids. The number of amino acids in the active isoforms range from 36 to 12. Apelin-13 and, to a lesser extent, apelin-36 are considered the most active isoforms with the greatest activity on the cardiovascular ...
FOLINO, Anna +3 more
openaire +3 more sources