Results 31 to 40 of about 8,460 (160)
MicroRNAs regulate APOBEC gene expression.
Histology and histopathology, 2017 Apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like (APOBEC) is a family of evolutionarily conserved cytidine deaminases, encoded by eleven genes located in the human genome. APOBECs play key roles in innate immunity through their ability to mutagenize viral DNA and restrict rival replication.
Cao, Wei, Wu, Wei
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Journal of Lipid Research, 1997 In humans, both the expression of apobec-1 and the C to U deamination of apoB mRNA are confined to the small intestine. In order to understand the tissue-restricted pattern of apobec-1 expression, we have isolated the chromosomal gene spanning the human ...
K Hirano +4 more
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The role of innate APOBEC3G and adaptive AID immune responses in HLA-HIV/SIV immunized SHIV infected macaques. [PDF]
PLoS ONE, 2012 The AID/APOBEC family (activation induced deaminase/apolipoprotein B mRNA editing cytokine deaminase) in B cells play important roles in adaptive and innate immunity.
Yufei Wang +10 more
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Characterization of SARS-CoV-2 Mutational Signatures from 1.5+ Million Raw Sequencing Samples
Viruses, 2022 We present a large-scale analysis of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) substitutions, considering 1,585,456 high-quality raw sequencing samples, aimed at investigating the existence and quantifying the effect of mutational ...
Andrea Aroldi +8 more
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Unveiling RNA Editing by ADAR and APOBEC Protein Gene Families
Frontiers in Bioscience-LandmarkRNA editing is a crucial post-transcriptional modification that alters the transcriptome and proteome and affects many cellular processes, including splicing, microRNA specificity, stability of RNA molecules, and protein structure.
Alexander Modestov +2 more
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APOBEC and Cancer Viroimmunotherapy: Thinking the Unthinkable
Clinical Cancer Research, 2021 AbstractThe apolipoprotein B mRNA editing enzyme catalytic polypeptide (APOBEC) family protects against infection by degrading incoming viral genomes through cytosine deamination. Here, we review how the potential to unleash these potent DNA mutagens comes at a price as APOBEC DNA mutagenesis can contribute to development of multiple types of cancer ...
Vile, RG +4 more
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OncoImmunology, 2019 Tumor-associated neo-antigens are mutated peptides that allow the immune system to recognize the affected cell as foreign. Cells carrying excessive mutation load often develop mechanisms of tolerance.
Amélie Boichard +8 more
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Molecular origins of APOBEC-associated mutations in cancer [PDF]
DNA Repair, 2020 The APOBEC family of cytidine deaminases has been proposed to represent a major enzymatic source of mutations in cancer. Here, we summarize available evidence that links APOBEC deaminases to cancer mutagenesis. We also highlight newly identified human cell models of APOBEC mutagenesis, including cancer cell lines with suspected endogenous APOBEC ...
Mia Petljak, John Maciejowski
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ApoB48 as an Efficient Regulator of Intestinal Lipid Transport
Frontiers in Physiology, 2020 Fatty meals induce intestinal secretion of chylomicrons (CMs) containing apolipoprotein (Apo) B48. These CMs travel via the lymphatic system before entering the circulation.
Chunmin C. Lo, Karen T. Coschigano
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AID/APOBEC–dependent somatic hypermutation and DNA rearrangements of immunoglobulin and non-immunoglobulin genes [PDF]
Annals of Mechnikov's Institute, 2019 Editing Ig genes by activation induced deaminase (AID) initiates the antibody diversification process in B lymphocytes.In mammalian B cells, this process includes somatic hypermutation (SHM) and class switch recombination (CSR).The activity of AID is ...
T Kolotova +3 more
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