Results 41 to 50 of about 8,460 (160)

APOBEC-Mediated Cytosine Deamination Links PIK3CA Helical Domain Mutations to Human Papillomavirus-Driven Tumor Development

Cell Reports, 2014
APOBEC3B cytosine deaminase activity has recently emerged as a significant mutagenic factor in human cancer. APOBEC activity is induced in virally infected cells, and APOBEC signature mutations occur at high frequency in cervical cancers (CESC), over 99%
Stephen Henderson, Ankur Chakravarthy, Xiaoping Su, Chris Boshoff, Tim Robert Fenton   +4 more
doaj   +1 more source

Discovery of an Adaptive Neuroimmune Response Driving Itch and Fast Tick Removal with Implications for Preventing Pathogen Transmission

Advanced Science, EarlyView.
Doehl et al. discovered an adaptive neuroimmune mechanism that induces itch in tick‐exposed guinea pigs, enabling rapid tick removal. This itch‐induced tick removal (IITR) is mediated by an adaptive cellular immune response and is independent of IgG, IgE, or TRPV1.
Johannes S. P. Doehl, Tiago D. Serafim, Serena Doh, Charles S. Grugan, Eva Iniguez, Luana Rogerio, Ronja Frigard, Ranadhir Dey, Pedro Cecilio, Xinglong Gu, Pang‐Yen Tseng, Aline da Silva Moreira, Mahnaz Minai, James Oristian, Hans Ackerman, Steven Brooks, Caroline Percopo, Siu‐Ping Ng, Derron A. Alves, Lucas Tirloni, Jennifer M. Anderson, Adriana Marques, Fabiano Oliveira, Shaden Kamhawi, Daniel E. Sonenshine, José M. C. Ribeiro, Mark Hoon, Jesus G. Valenzuela   +27 more
wiley   +1 more source

Restriction of Foamy Viruses by APOBEC Cytidine Deaminases [PDF]

Journal of Virology, 2006
ABSTRACT Foamy viruses (FVs) are nonpathogenic retroviruses infecting many species of mammals, notably primates, cattle, and cats. We have examined whether members of the apolipoprotein B-editing catalytic polypeptide-like subunit (APOBEC) family of antiviral cytidine deaminases restrict replication of simian FV.
Delebecque, Frédéric, Suspene, Rodolphe, Calattini, Sara, Casartelli, Nicoletta, Saib, Ali, Froment, Alain, Wain-Hobson, Simon, Gessain, Antoine, Vartanian, Jean Pierre, Schwartz, Olivier   +9 more
openaire   +4 more sources

Repeated Disuse Atrophy Imprints a Molecular Memory in Skeletal Muscle: Transcriptional Resilience in Young Adults and Susceptibility in Aged Muscle

Advanced Science, EarlyView.
Repeated disuse imprints a molecular memory in skeletal muscle, conferring transcriptional resilience in young adults but exaggerated susceptibility in aged muscle, driven by epigenetic regulation of aerobic metabolism, mitochondrial and NAD+ pathways.
Daniel C. Turner, Truls Raastad, Max Ullrich, Stian F. Christiansen, Hazel Sutherland, James Boot, Eva Wozniak, Charles Mein, Emilie Dalbram, Jonas T. Treebak, Daniel J. Owens, David C. Hughes, Sue C. Bodine, Jonathan C. Jarvis, Adam P. Sharples   +14 more
wiley   +1 more source

Hepatic secretion of apoB-100 is impaired in hypobetalipoproteinemic mice with an apoB-38.9-specifying allele

Journal of Lipid Research, 2004
Apolipoprotein B (apoB) truncation-specifying mutations cause familial hypobetalipoproteinemia (FHBL). Lipoprotein kinetics studies have shown that production rates of apoB-100 are reduced by 70–80% in heterozygous FHBL humans, instead of the expected 50%
Zhouji Chen, Robin L. Fitzgerald, Gang Li, Nicholas O. Davidson, Gustav Schonfeld   +4 more
doaj   +1 more source

The Genomic Evolution of Early‐Stage Non‐Small Cell Lung Cancer

Medicine Advances, EarlyView.
This study provides a comprehensive overview of the genomic landscape of early‐stage non‐small cell lung cancer, identifying the 4q12 deletion as a potential exclusive biomarker for the “oncogenic switch” from pre‐invasive to invasive lesions. It delineates that while EGFR and TP53 mutations act as early truncal drivers, the progressive increase in ...
Huatao Tang, Yang Zhang, Haiquan Chen
wiley   +1 more source

FHIT loss-induced DNA damage creates optimal APOBEC substrates: Insights into APOBEC-mediated mutagenesis

Oncotarget, 2014
APOBEC cytidine deaminase activity is a major source of hypermutation in cancer. But previous studies have shown that the TC context signature of these enzymes is not observed in sizable fractions of cancers with overexpression of APOBEC, suggesting that cooperating factors that contribute to this mutagenesis should be identified. The fragile histidine
Catherine E, Waters, Joshua C, Saldivar, Zaynab A, Amin, Morgan S, Schrock, Kay, Huebner   +4 more
openaire   +3 more sources

Integrative genomic analyses of APOBEC-mutational signature, expression and germline deletion of APOBEC3 genes, and immunogenicity in multiple cancer types

BMC Medical Genomics, 2019
Background Although APOBEC-mutational signature is found in tumor tissues of multiple cancers, how a common germline APOBEC3A/B deletion affects the mutational signature remains unclear.
Zhishan Chen, Wanqing Wen, Jiandong Bao, Krystle L. Kuhs, Qiuyin Cai, Jirong Long, Xiao-ou Shu, Wei Zheng, Xingyi Guo   +8 more
doaj   +1 more source

RNA Editing Alterations Define Disease Manifestations in the Progression of Experimental Autoimmune Encephalomyelitis (EAE)

Cells, 2022
RNA editing is an epitranscriptomic modification, leading to targeted changes in RNA transcripts. It is mediated by the action of ADAR (adenosine deaminases acting on double-stranded (ds) RNA and APOBEC (apolipoprotein B mRNA editing enzyme catalytic ...
Dimitra Dafou, Eirini Kanata, Spyros Pettas, Nikolaos Bekas, Athanasios Dimitriadis, Garyfalia Kempapidou, Roza Lagoudaki, Paschalis Theotokis, Olga Touloumi, Nikoleta Delivanoglou, Evangelia Kesidou, Konstantinos Xanthopoulos, Nikolaos Grigoriadis, Fotini Nina Papavasiliou, Theodoros Sklaviadis   +14 more
doaj   +1 more source

Intrinsic immunity against retrotransposons by APOBEC cytidine deaminases [PDF]

Frontiers in Microbiology, 2013
Over 40% of the human genome is recognizable as having been derived from ancient retroelements, transported by an intracellular copy-and-paste process involving an RNA intermediate, with an additional few percent classified as DNA transposable elements.
Koito, Atsushi, Ikeda, Terumasa
openaire   +3 more sources