Results 91 to 100 of about 7,631 (195)

Exploring ABOBEC3A and APOBEC3B substrate specificity and their role in HPV positive head and neck cancer

iScience, 2022
Summary: APOBEC3 family members are cytidine deaminases catalyzing conversion of cytidine to uracil. Many studies have established a link between APOBEC3 expression and cancer development and progression, especially APOBEC3A (A3A) and APOBEC3B (A3B ...
Christina Papini, Zechen Wang, Shalley N. Kudalkar, Travis Parke Schrank, Su Tang, Tomoaki Sasaki, Cory Wu, Brandon Tejada, Samantha J. Ziegler, Yong Xiong, Natalia Issaeva, Wendell G. Yarbrough, Karen S. Anderson   +12 more
doaj   +1 more source

AID/APOBEC-network reconstruction identifies pathways associated with survival in ovarian cancer [PDF]

, 2016
Background Building up of pathway-/disease-relevant signatures provides a persuasive tool for understanding the functional relevance of gene alterations and gene network associations in multifactorial human diseases.
Birner, Peter, Braicu, Ioana, Castillo-Tong,Dan Cacsire, Hager, Gudrun, Heinze, Georg, Jaritz, Markus, Jensen-Jarolim, Erika, Lambrechts, Sandrina, Mahner, Sven, Mechtcheriakova, Diana, Meshcheryakova, Anastasia, Pils, Dietmar, Sehouli, Jalid, Svoboda, Martin, Thalhammer, Theresia, Vergote, Ignace, Zeillinger, Robert, Zimmermann, Philip   +17 more
core   +2 more sources

APOBEC3C‐Mediated NF‐κB Activation Promotes Malignant Progression of Gliomas

Immunity, Inflammation and Disease, Volume 13, Issue 7, July 2025.
The results of this study suggest that high expression of APOBEC3C is associated with poor prognosis in glioma and may affect immune regulation. Knocking down APOBEC3C can inhibit the invasion and migration abilities of glioma cells. In addition, APOBEC3C can regulate the activation of the NF‐κB signaling pathway, which is expected to be a target for ...
Chao Zhang, Tao Yang, Yuhang Tang, Dong Yu, Shiqiang Hou, Ning Lin, Qun Li   +6 more
wiley   +1 more source

APOBEC3B-mediated corruption of the tumor cell immunopeptidome induces heteroclitic neoepitopes for cancer immunotherapy

Nature Communications, 2020
DNA mutations induced by dysregulated APOBEC3 expression are associated with tumour-progression and therapeutic resistance, but also with the generation of neoepitopes. Here, the authors show that APOBEC3 function can be exploited in a vaccine setting to
Christopher B. Driscoll, Matthew R. Schuelke, Timothy Kottke, Jill M. Thompson, Phonphimon Wongthida, Jason M. Tonne, Amanda L. Huff, Amber Miller, Kevin G. Shim, Amy Molan, Cynthia Wetmore, Peter Selby, Adel Samson, Kevin Harrington, Hardev Pandha, Alan Melcher, Jose S. Pulido, Reuben Harris, Laura Evgin, Richard G. Vile   +19 more
doaj   +1 more source

Differential inhibition of LINE1 and LINE2 retrotransposition by vertebrate AID/APOBEC proteins [PDF]

, 2013
BACKGROUND: The role of AID/APOBEC proteins in the mammalian immune response against retroviruses and retrotransposons is well established. G to A hypermutations, the hallmark of their cytidine deaminase activity, are present in several mammalian ...
Binyamin A Knisbacher, Erez Y Levanon, Maruška Budič, Nataša Lindič, Nika Lovšin, Toni Petan   +5 more
core   +1 more source

Interdisciplinary Approach to Monkeypox Prevention: Integrating Nanobiosensors, Nanovaccines, Artificial Intelligence, Visual Arts, and Social Sciences

Small Structures, Volume 6, Issue 7, July 2025.
This illustration depicts a comprehensive strategy against monkeypox, showcasing its transmission, symptoms, and prevention. Centralized around nanomaterials and biosensors, it integrates early screening, Internet of Things, vaccination, and community involvement through collaboration among healthcare workers, scientists, researchers, social groups ...
Vishal Chaudhary, Lucky Lucky, Harsh Sable, Nikhil Bhalla   +3 more
wiley   +1 more source

Harnessing novel cytidine deaminases from the animal kingdom for robust multiplexed base editing in rice

Plant Biotechnology Journal, Volume 23, Issue 5, Page 1702-1712, May 2025.
Summary CRISPR‐Cas‐based cytosine base editors (CBEs) are prominent tools that perform site‐specific and precise C‐to‐T conversions catalysed by cytidine deaminases. However, their use is often constrained by stringent editing preferences for genomic contexts, off‐target effects and restricted editing windows.
Danyel Fernandes Contiliani, Simon Sretenovic, Micah Dailey, Man Zhou, Yanhao Cheng, Silvana Creste, Shunyuan Xiao, Yiping Qi   +7 more
wiley   +1 more source

All APOBEC3 family proteins differentially inhibit LINE-1 retrotransposition [PDF]

Nucleic Acids Research, 2007
Approximately 17% of the human genome is comprised of long interspersed nuclear element 1 (LINE-1, L1) non-LTR retrotransposons. L1 retrotransposition is known to be the cause of several genetic diseases, such as hemophilia A, Duchene muscular dystrophy, and so on.
Kinomoto, Masanobu, Kanno, Takayuki, Shimura, Mari, Ishizaka, Yukihito, Kojima, Asato, Kurata, Takeshi, Sata, Tetsutaro, Tokunaga, Kenzo   +7 more
openaire   +2 more sources

APOBEC3B Does Not Promote Tumor Progression in Tp53 Hemizygous Mice

Cancer Reports, Volume 8, Issue 4, April 2025.
ABSTRACT Background DNA cytosine deaminase APOBEC3B (A3B) is one of the endogenous sources of somatic mutations in many types of human cancers and is associated with tumor progression rather than tumorigenesis. However, it remains uncertain whether APOBEC3B‐induced mutations accelerate tumor progression or not.
Yoshihito Horisawa, Tadahiko Matsumoto, June Takeda, Yusuke Tashiro, Ryosuke Nomura, Suguru Takeuchi, Yugo Kawai, Yasuhiro Kazuma, Yoshinobu Konishi, Hiroyuki Yamazaki, Hiroyuki Matsui, Kotaro Shirakawa, Akifumi Takaori‐Kondo   +12 more
wiley   +1 more source

CAPIH: A Web interface for comparative analyses and visualization of host-HIV protein-protein interactions [PDF]

, 2009
Background The Human Immunodeficiency Virus type one (HIV-1) is the major causing pathogen of the Acquired Immune Deficiency Syndrome (AIDS). A large number of HIV-1-related studies are based on three non-human model animals: chimpanzee, rhesus macaque ...
Chuang Trees-Juen, Yang Jinn-Moon, Pan Chia-Lin, Lin Fan-Kai, Chen Feng-Chi   +4 more
core   +2 more sources