Results 101 to 110 of about 7,631 (195)

APOBEC3 proteins can copackage and comutate HIV-1 genomes [PDF]

Nucleic Acids Research, 2016
Although APOBEC3 cytidine deaminases A3G, A3F, A3D and A3H are packaged into virions and inhibit viral replication by inducing G-to-A hypermutation, it is not known whether they are copackaged and whether they can act additively or synergistically to inhibit HIV-1 replication.
Desimmie, Belete A., Burdick, Ryan C., Izumi, Taisuke, Doi, Hibiki, Shao, Wei, Alvord, W. Gregory, Sato, Kei, Koyanagi, Yoshio, Jones, Sara, Wilson, Eleanor, Hill, Shawn, Maldarelli, Frank, Hu, Wei-Shau, Pathak, Vinay K.   +13 more
openaire   +2 more sources

A review of Mpox: Biological characteristics, epidemiology, clinical features, diagnosis, treatment, and prevention strategies

Exploration, Volume 5, Issue 2, April 2025.
The monkeypox virus (MPXV) has spread to many countries and caused thousands of infections all over the world. This review comprehensively introduces the biology, epidemiological characteristics of MPXV, and clinical manifestations of Mpox. The approaches for diagnosis, treatment, and prevention are also introduced, aiming to improve the general ...
Lin Jiang, Ailan Xu, Lin Guan, Yong Tang, Guangshuai Chai, Junya Feng, Yueqi Wu, Maochen Li, Chuxie Zhang, Xiaojing Liu, Xiaolong Xu, Qingquan Liu, Lihua Song, Yigang Tong, Renald Blundell, Huahao Fan   +15 more
wiley   +1 more source

Structure-Guided Analysis of the Human APOBEC3-HIV Restrictome [PDF]

Structure, 2014
Human APOBEC3 (A3) proteins are host-encoded intrinsic restriction factors that inhibit the replication of many retroviral pathogens. Restriction is believed to occur as a result of the DNA cytosine deaminase activity of the A3 proteins; this activity converts cytosines into uracils in single-stranded DNA retroviral replication intermediates.
Aydin, Halil, Taylor, Matthew W., Lee, Jeffrey E.   +2 more
openaire   +2 more sources

Development and validation of a novel prognostic lncRNA signature based on the APOBEC3 family genes in gastric cancer

Heliyon
Introduction: Gastric Cancer (GC) refers to a prevalent malignant cancer accompanied by a weak prognosis. The APOBEC3 family genes and lncRNAs are linked with cancer progression.
Jia Qi, Wenxuan Wu, Jing Chen, Xiaying Han, Zhixing Hao, Yaxuan Han, Yewei Xu, Jun Lai, Jian Chen   +8 more
doaj   +1 more source

Elevated APOBEC3B Correlates with Poor Outcomes for Estrogen-Receptor-Positive Breast Cancers [PDF]

, 2014
Recent observations connected DNA cytosine deaminase APOBEC3B to the genetic evolution of breast cancer. We addressed whether APOBEC3B is associated with breast cancer clinical outcomes.
Burns, Michael B., Foekens, John A., Gelder, Marion E. Meijer-Van, Gray, Kathryn P., Harris, Reuben S., Heideman, Marinus R., Jacobs, Heinz, Leyland-Jones, Brian, Look, Maxime P., Martens, John W. M., Schlicker, Andreas, Sieuwerts, Anieta M., Wessels, Lodewyk, Willis, Scooter   +13 more
core   +3 more sources

Monkeypox: Prevention Strategies and Challenges: Updated Review

Health Science Reports, Volume 8, Issue 4, April 2025.
ABSTRACT Background and Aims The mpox virus, sometimes known as MPXV, is the cause of the disease mpox. The Monkeypox virus is a different Poxviridae family member from the orthopoxvirus (OPXV) group. Clades I and II are the two varieties of the Monkeypox virus.
Abate Wondesen Tsige, Siraye Genzeb Ayele   +1 more
wiley   +1 more source

Enrichment of G‐to‐U Substitution in SARS‐CoV‐2 Functional Regions and Its Compensation via Concurrent Mutations

Journal of Medical Virology, Volume 97, Issue 4, April 2025.
ABSTRACT We surveyed single nucleotide variant (SNV) patterns from 5 903 647 complete SARS‐CoV‐2 genomes. Among 10 012 SNVs, APOBEC‐mediated C‐to‐U (C > U) deamination was the most prevalent, followed by G > U and other RNA editing‐related substitutions including (A > G, U > C, G > A).
Xierzhatijiang Sulaiman, Yan Han, Sheng Liu, Kailing Li, Marissa Shang, Lei Yang, Kenneth White, Yong Zang, Jikui Shen, Jun Wan   +9 more
wiley   +1 more source

Footprint of APOBEC3 on the Genome of Human Retroelements [PDF]

Journal of Virology, 2013
ABSTRACT Almost half of the human genome is composed of transposable elements. The genomic structures and life cycles of some of these elements suggest they are a result of waves of retroviral infection and transposition over millions of years.
Firoz, Anwar, Miles P, Davenport, Diako, Ebrahimi   +2 more
openaire   +2 more sources

Remembering the forgotten child: the role of immune checkpoint inhibition in patients with human immunod eficiency virus and cancer. [PDF]

, 2019
Patients with human immunodeficiency virus (HIV) infection have a high risk of developing virally-mediated cancers. These tumors have several features that could make them vulnerable to immune checkpoint inhibitors (ICIs) including, but not limited to ...
Adashek, Jacob J, Galanina, Natalie, Junior, Pedro Nazareth Aguiar, Kurzrock, Razelle   +3 more
core  

Type I Interferon at the Interface of Antiviral Immunity and Immune Regulation: The Curious Case of HIV-1. [PDF]

, 2013
Type I interferon (IFN-I) play a critical role in the innate immune response against viral infections. They actively participate in antiviral immunity by inducing molecular mechanisms of viral restriction and by limiting the spread of the infection, but ...
Boasso, A
core   +2 more sources