Model structure of human APOBEC3G. [PDF]
PLoS ONE, 2007 APOBEC3G (apolipoprotein B mRNA-editing enzyme, catalytic polypeptide-like 3G) has antiretroviral activity associated with the hypermutation of viral DNA through cytosine deamination.
Kun-Lin Zhang +6 more
doaj +5 more sources
An immunometabolism-related signature for renal clear cell carcinoma diagnosis and therapeutic target. [PDF]
J Cell Commun SignalAbstract Kidney renal clear cell carcinoma (KIRC) lacks sensitive early diagnostic markers and effective therapeutic guidance. Given the tight crosstalk between tumor metabolism and immunity, we investigated immunometabolism for biomarker discovery.
Hu G, Liang J, Feng M, Lin H, He J.
europepmc +2 more sources
Variability in HIV-1 transmitted/founder virus susceptibility to combined APOBEC3F and APOBEC3G host restriction [PDF]
Journal of VirologySeveral APOBEC3 enzymes restrict HIV-1 by deaminating cytosine to form uracil in single-stranded proviral (−)DNA. However, HIV-1 Vif counteracts their activity by inducing their proteasomal degradation.
Amit Gaba +3 more
doaj +2 more sources
Molecules, 2022 The apolipoprotein B mRNA editing enzyme catalytic subunit 3G (APOBEC3G) converts cytosine to uracil in DNA/RNA. Its role in resisting viral invasion has been well documented.
Chenchen Ma +6 more
doaj +1 more source
Effects of APOBEC3G on the replications of severe fever with thrombocytopenia syndrome virus
Zhongguo shuxue zazhi, 2023 Objective To study the effect of apolipoprotein B mRNA editing enzyme catalytic subunit 3G (APOBEC3G)on virus replication and IL-6 production during severe fever with thrombocytopenia syndrome virus (SFTSV) infection.
Yanixn TAO +5 more
doaj +1 more source
Retroviral restriction factor APOBEC3G delays the initiation of DNA synthesis by HIV-1 reverse transcriptase. [PDF]
PLoS ONE, 2013 It is well established that the cytosine deaminase APOBEC3G can restrict HIV-1 virions in the absence of the virion infectivity factor (Vif) by inducing genome mutagenesis through deamination of cytosine to uracil in single-stranded HIV-1 (-)DNA. However,
Madison B Adolph +2 more
doaj +1 more source
APOBEC3G polymorphism as a selective barrier to cross-species transmission and emergence of pathogenic SIV and AIDS in a primate host. [PDF]
PLoS Pathogens, 2013 Cellular restriction factors, which render cells intrinsically resistant to viruses, potentially impose genetic barriers to cross-species transmission and emergence of viral pathogens in nature. One such factor is APOBEC3G.
Annabel Krupp +6 more
doaj +1 more source
Differences in APOBEC3G expression in CD4+ T helper lymphocyte subtypes modulate HIV-1 infectivity. [PDF]
PLoS Pathogens, 2009 The cytidine deaminases APOBEC3G and APOBEC3F exert anti-HIV-1 activity that is countered by the HIV-1 vif protein. Based on potential transcription factor binding sites in their putative promoters, we hypothesized that expression of APOBEC3G and ...
Michael L Vetter +4 more
doaj +1 more source
Heliyon, 2022 Background: Kidney renal clear cell carcinoma (KIRC) is the most common pathological subtype of renal cell cancer. APOBEC3 activity has been identified in a variety of human cancers.
Ting Peng +9 more
doaj +1 more source
APOBEC3G-Augmented Stem Cell Therapy to Modulate HIV Replication: A Computational Study. [PDF]
PLoS ONE, 2013 The interplay between the innate immune system restriction factor APOBEC3G and the HIV protein Vif is a key host-retrovirus interaction. APOBEC3G can counteract HIV infection in at least two ways: by inducing lethal mutations on the viral cDNA; and by ...
Iraj Hosseini, Feilim Mac Gabhann
doaj +1 more source