Results 11 to 20 of about 5,264 (176)

APOBEC3G-UBA2 fusion as a potential strategy for stable expression of APOBEC3G and inhibition of HIV-1 replication [PDF]

Retrovirology, 2008
Background Although APOBEC3G protein is a potent and innate anti-HIV-1 cellular factor, HIV-1 Vif counteracts the effect of APOBEC3G by promoting its degradation through proteasome-mediated proteolysis.
Li Lin, Liang Dong, Li Jing-yun, Zhao Richard Y   +3 more
doaj   +3 more sources

APOBEC3G & HTLV-1: Inhibition without deamination [PDF]

Retrovirology, 2005
APOBEC3G is a cellular cytidine deaminase that was recently identified as the Vif-sensitive antiviral host factor responsible for the restriction of vif-defective HIV-1 in primary human cells and certain non-permissive T cell lines.
Strebel Klaus
doaj   +3 more sources

Characterization of APOBEC3G binding to 7SL RNA [PDF]

Retrovirology, 2008
Human APOBEC3 proteins are editing enzymes that can interfere with the replication of exogenous retroviruses such as human immunodeficiency virus (HIV), hepadnaviruses such as hepatitis B virus (HBV), and with the retrotransposition of endogenous ...
Lakkaraju Asvin, Mangeat Bastien, Peddi Shyam, Bach Daniel, Strub Katharina, Trono Didier   +5 more
doaj   +4 more sources

APOBEC3G: an intracellular centurion [PDF]

Philosophical Transactions of the Royal Society B: Biological Sciences, 2008
The intrinsic antiretroviral factor APOBEC3G (A3G) is highly active against HIV-1 and other retroviruses. In different cell types, A3G is expressed in high-molecular-mass (HMM) RNA–protein complexes or low-molecular-mass (LMM) forms displaying different biological activities.
Ya-Lin, Chiu, Warner C, Greene
openaire   +2 more sources

APOBEC3G Targets Specific Virus Species [PDF]

Journal of Virology, 2004
ABSTRACT Human APOBEC3G (huAPOBEC3G), also known as CEM15, is a broad antiretroviral host factor that deaminates dC to dU in the minus strand DNA of human immunodeficiency virus type 1 (HIV-1), other lentiviruses, and murine leukemia virus (MLV), thereby creating G-to-A hypermutation in the plus strand DNA to inhibit the infectivity of these ...
Masayuki, Kobayashi, Akifumi, Takaori-Kondo, Keisuke, Shindo, Aierken, Abudu, Keiko, Fukunaga, Takashi, Uchiyama   +5 more
openaire   +2 more sources

Small-Angle X-ray Scattering (SAXS) Measurements of APOBEC3G Provide Structural Basis for Binding of Single-Stranded DNA and Processivity

Viruses, 2022
APOBEC3 enzymes are polynucleotide deaminases, converting cytosine to uracil on single-stranded DNA (ssDNA) and RNA as part of the innate immune response against viruses and retrotransposons. APOBEC3G is a two-domain protein that restricts HIV.
Fareeda M. Barzak, Timothy M. Ryan, Nazanin Mohammadzadeh, Stefan Harjes, Maksim V. Kvach, Harikrishnan M. Kurup, Kurt L. Krause, Linda Chelico, Vyacheslav V. Filichev, Elena Harjes, Geoffrey B. Jameson   +10 more
doaj   +1 more source

Selective inhibition of Alu retrotransposition by APOBEC3G [PDF]

Gene, 2007
The non-LTR retrotransposon LINE-1 (L1) comprises approximately 17% of the human genome, and the L1-encoded proteins can function in trans to mediate the retrotransposition of non-autonomous retrotransposons (i.e., Alu and probably SVA elements) and cellular mRNAs to generate processed pseudogenes.
Amy E, Hulme, Hal P, Bogerd, Bryan R, Cullen, John V, Moran   +3 more
openaire   +2 more sources

Vaccinia virus replication is not affected by APOBEC3 family members

Virology Journal, 2006
Background The APOBEC3G protein represents a novel innate defense mechanism against retroviral infection. It facilitates the deamination of the cytosine residues in the single stranded cDNA intermediate during early steps of retroviral infection.
Sutter Gerd, Münk Carsten, Martinez-Fernandez Yolanda, Suezer Yasemin, Kremer Melanie, Schnierle Barbara S   +5 more
doaj   +1 more source

Different mutagenic potential of HIV-1 restriction factors APOBEC3G and APOBEC3F is determined by distinct single-stranded DNA scanning mechanisms. [PDF]

PLoS Pathogens, 2014
The APOBEC3 deoxycytidine deaminase family functions as host restriction factors that can block replication of Vif (virus infectivity factor) deficient HIV-1 virions to differing degrees by deaminating cytosines to uracils in single-stranded (-)HIV-1 DNA.
Anjuman Ara, Robin P Love, Linda Chelico
doaj   +1 more source

Rapid evolution of primate antiviral enzyme APOBEC3G [PDF]

Human Molecular Genetics, 2004
Human cytidine deaminase APOBEC3G and the virion infectivity factor (vif) of the human immunodeficiency virus (HIV) are a pair of antagonistic molecules. In the absence of vif, APOBEC3G induces a high rate of dC to dU mutations in the nascent reverse transcripts of HIV that leads to the degradation of the HIV genome.
Jianzhi, Zhang, David M, Webb
openaire   +2 more sources