Results 21 to 30 of about 5,264 (176)

The Roles of APOBEC3G Complexes in the Incorporation of APOBEC3G into HIV-1

PLoS ONE, 2013
The incorporation of human APOBEC3G (hA3G) into HIV is required for exerting its antiviral activity, therefore the mechanism underlying hA3G virion encapsidation has been investigated extensively. hA3G was shown to form low-molecular-mass (LMM) and high-molecular-mass (HMM) complexes.
Jing Ma, Xiaoyu Li, Jian Xu, Quan Zhang, Zhenlong Liu, Pingping Jia, Jinming Zhou, Fei Guo, Xuefu You, Liyan Yu, Lixun Zhao, Jiandong Jiang, Shan Cen   +12 more
openaire   +4 more sources

Production of infectious human immunodeficiency virus type 1 does not require depletion of APOBEC3G from virus-producing cells

Retrovirology, 2004
Background The human immunodeficiency virus Vif protein overcomes the inhibitory activity of the APOBEC3G cytidine deaminase by prohibiting its packaging into virions. Inhibition of APOBEC3G encapsidation is paralleled by a reduction of its intracellular
Goila-Gaur Ritu, Opi Sandrine, Takeuchi Hiroaki, Khan Mohammad A, Miyagi Eri, Kao Sandra, Strebel Klaus   +6 more
doaj   +1 more source

Random mutagenesis MAPPIT analysis identifies binding sites for Vif and Gag in both cytidine deaminase domains of Apobec3G. [PDF]

PLoS ONE, 2012
The mammalian two-hybrid system MAPPIT allows the detection of protein-protein interactions in intact human cells. We developed a random mutagenesis screening strategy based on MAPPIT to detect mutations that disrupt the interaction of one protein with ...
Isabel Uyttendaele, Delphine Lavens, Dominiek Catteeuw, Irma Lemmens, Celia Bovijn, Jan Tavernier, Frank Peelman   +6 more
doaj   +1 more source

Functional domain organization of human APOBEC3G

Virology, 2008
Human APOBEC3 proteins exist in two forms containing either a single cytidine deaminase domain (CDA) or two CDAs. Strikingly, the proteins that are capable of effectively inhibiting the infectivity of Vif-deficient HIV-1 (HIV-1DeltaVif), such as APOBEC3G (A3G), contain two CDAs.
Gooch, Barry D., Cullen, Bryan R.
openaire   +2 more sources

Reassessing the role of APOBEC3G in human immunodeficiency virus type 1 infection of quiescent CD4+ T-cells. [PDF]

PLoS Pathogens, 2009
HIV-1 is restricted for infection of primary quiescent T-cells. After viral entry, reverse transcription is initiated but is not completed. Various hypotheses have been proposed for this cellular restriction including insufficient nucleotide pools and ...
Masakazu Kamata, Yoshiko Nagaoka, Irvin S Y Chen   +2 more
doaj   +1 more source

APOBEC3G: a double agent in defense [PDF]

Trends in Biochemical Sciences, 2011
APOBEC3G (A3G) is an effective cellular host defense factor under experimental conditions in which a functional form of the HIV-encoded protein Vif cannot be expressed. Wild-type Vif targets A3G for proteasomal degradation and when this happens, any host defense advantage A3G might provide is severely diminished or lost.
openaire   +2 more sources

AID and Apobec3G haphazard deamination and mutational diversity [PDF]

Cellular and Molecular Life Sciences, 2012
Activation-induced deoxycytidine deaminase (AID) and Apobec 3G (Apo3G) cause mutational diversity by initiating mutations on regions of single-stranded (ss) DNA. Expressed in B cells, AID deaminates C → U in actively transcribed immunoglobulin (Ig) variable and switch regions to initiate the somatic hypermutation (SHM) and class switch recombination ...
Malgorzata, Jaszczur, Jeffrey G, Bertram, Phuong, Pham, Matthew D, Scharff, Myron F, Goodman   +4 more
openaire   +2 more sources

APOBEC3G targets human T-cell leukemia virus type 1

Retrovirology, 2005
Background Apolipoprotein B mRNA-editing enzyme-catalytic polypeptide-like 3G (APOBEC3G) is a host cellular protein with a broad antiviral activity.
Imada Kazunori, Hishizawa Masakatsu, Abudu Aierkin, Kobayashi Masayuki, Shirakawa Kotaro, Takaori-Kondo Akifumi, Sasada Amane, Tanaka Yuetsu, Uchiyama Takashi   +8 more
doaj   +1 more source

Structural basis of sequence-specific RNA recognition by the antiviral factor APOBEC3G

Nature Communications, 2022
Interaction between APOBEC3G and RNA is critical for its antiviral function. Here, the authors report four co-crystal structures of rhesus macaque APOBEC3G and RNA, demonstrating unpaired AA and GA dinucleotide motifs are preferentially recognized.
Hanjing Yang, Kyumin Kim, Shuxing Li, Josue Pacheco, Xiaojiang S. Chen   +4 more
doaj   +1 more source

Structural and functional assessment of APOBEC3G macromolecular complexes [PDF]

Methods, 2016
There are eleven members in the human APOBEC family of proteins that are evolutionarily related through their zinc-dependent cytidine deaminase domains. The human APOBEC gene clusters arose on chromosome 6 and 22 through gene duplication and divergence to where current day APOBEC proteins are functionally diverse and broadly expressed in tissues ...
Bogdan, Polevoda, William M, McDougall, Ryan P, Bennett, Jason D, Salter, Harold C, Smith   +4 more
openaire   +2 more sources