Results 11 to 20 of about 92,863 (145)

Apolipoprotein Mimetic Peptides: A New Approach for the Treatment of Asthma

Frontiers in Pharmacology, 2012
New treatments are needed for severe asthmatics to improve disease control and avoid severe toxicities associated with oral corticosteroids. We have used a murine model of house dust mite (HDM)-induced asthma to identify steroid-unresponsive genes that ...
Xianglan eYao, Michael P. Vitek, Alan T. Remaley, Stewart J. Levine   +3 more
doaj   +1 more source

Hypertriglyceridemia promotes dysfunctions in high-density lipoprotein increasing the cardiovascular risk

Brazilian Journal of Pharmaceutical Sciences, 2023
Hypertriglyceridemia is associated with several metabolic diseases. The triglycerides (TG) disrupt the cholesterol reverse transport and contribute to increased levels of low-density lipoprotein (LDL).
Richard Rarison Cavalcante Meneses, Nágila Raquel Teixeira Damasceno, Flávia De Conti Cartolano, Sara Maria Moreira Lima Verde, Letícia Gomes Lira, Mariana Brito Dantas, Glautemberg de Almeida Viana, Mateus Edson da Silva, Ederson Laurindo Holanda de Sousa, Gdayllon Cavalcante Meneses, Jamile Magalhães Ferreira, Tiago Lima Sampaio, Maria Goretti Rodrigues de Queiroz   +12 more
doaj   +1 more source

Intestine may be a major site of action for the apoA-I mimetic peptide 4F whether administered subcutaneously or orally[S]

Journal of Lipid Research, 2011
To determine if the dose of peptide administered or the plasma level was more important, doses of 0.15, 0.45, 4.5, or 45 mg/kg/day of the peptide D-4F were administered orally or subcutaneously (SQ) to apoliptotein (apo)E null mice.
Mohamad Navab, Srinivasa T. Reddy, G.M. Anantharamaiah, Satoshi Imaizumi, Greg Hough, Susan Hama, Alan M. Fogelman   +6 more
doaj   +1 more source

Active plasma phospholipid transfer protein is associated with apoA-I- but not apoE-containing lipoproteins

Journal of Lipid Research, 2006
Plasma phospholipid transfer protein (PLTP) is a multifaceted protein with diverse biological functions. It has been shown to exist in both active and inactive forms.
Marian C. Cheung, John J. Albers
doaj   +1 more source

A novel method for oral delivery of apolipoprotein mimetic peptides synthesized from all L-amino acids

Journal of Lipid Research, 2009
Administered subcutaneously, D-4F or L-4F are equally efficacious, but only D-4F is orally efficacious because of digestion of L-4F by gut proteases. Orally administering niclosamide (a chlorinated salicylanilide used as a molluscicide, antihelminthic ...
Mohamad Navab, Piotr Ruchala, Alan J. Waring, Robert I. Lehrer, Susan Hama, Greg Hough, Mayakonda N. Palgunachari, G.M. Anantharamaiah, Alan M. Fogelman   +8 more
doaj   +1 more source

Apolipoprotein A-I Deficiency [PDF]

Arteriosclerosis, Thrombosis, and Vascular Biology, 1995
Abstract Familial HDL deficiencies are associated with variable susceptibility to premature coronary heart disease, but the mechanism underlying this association remains poorly understood. Three homozygotes with isolated complete apo A-I deficiency caused by an autosomal codominant apo A-I Q[−2]X mutation and one heterozygote ...
D S, Ng, C, Vezina, T S, Wolever, A, Kuksis, R A, Hegele, P W, Connelly   +5 more
openaire   +2 more sources

Human apoA-I expression in CETP transgenic rats leads to lower levels of apoC-I in HDL and to magnification of CETP-mediated lipoprotein changes1

Journal of Lipid Research, 2006
Plasma cholesteryl ester transfer protein (CETP) has a profound effect on neutral lipid transfers between HDLs and apolipoprotein B (apoB)-containing lipoproteins when it is expressed in combination with human apoA-I in HuAI/CETP transgenic (Tg) rodents.
David Masson, Jean-Paul Pais de Barros, Zoulika Zak, Thomas Gautier, Naig Le Guern, Mahfoud Assem, Jeffrey W. Chisholm, James R. Paterniti, Jr., Laurent Lagrost   +8 more
doaj   +1 more source

Alteration of plasma HDL cholesteryl ester composition with transgenic expression of a point mutation (E149A) of human LCAT

Journal of Lipid Research, 2001
We have previously identified a single amino acid mutation (hE149A) in human LCAT that increases its in vitro reactivity with phosphatidylcholine species containing sn-2 arachidonate (Wang et al. 1997. J. Biol. Chem. 272: 280–286).
James W. Furbee, Jr., Omar Francone, John S. Parks   +2 more
doaj   +1 more source

Denaturation of apolipoprotein A‐I and the monomer form of apolipoprotein A‐I_Milano [PDF]

European Journal of Biochemistry, 1999
In this study the thermal and denaturant induced unfolding of apolipoprotein A‐I (apo A‐I) and the monomer form of apolipoprotein A‐IMilano (apo A‐IM) was followed. Dimer apo A‐IM was reduced with dithiothreitol, which was present in the protein solutions in all experiments.
M, Suurkuusk, D, Hallén
openaire   +2 more sources

A proteomic study of the apolipoproteins in LDL subclasses in patients with the metabolic syndrome and type 2 diabetes

Journal of Lipid Research, 2005
The exchangeable apolipoproteins present in small, dense LDL (sdLDL) and large, buoyant LDL subclasses were evaluated with a quantitative proteomic approach in patients with the metabolic syndrome and with type 2 diabetes, both with subclinical ...
Pia Davidsson, Johannes Hulthe, Björn Fagerberg, Britt-Marie Olsson, Carina Hallberg, Björn Dahllöf, Germán Camejo   +6 more
doaj   +1 more source