Results 41 to 50 of about 92,863 (145)

An Apolipoprotein A-I Mimetic Works Best in the Presence of Apolipoprotein A-I [PDF]

Circulation Research, 2005
See related article, pages 1190–1197 Ou et al1 report that an apolipoprotein A-I (apoA-I) mimetic peptide, D-4F, reduced wall thickness and improved vasoreactivity in the fascialis artery (internal diameter 180 to 240 μm) in low-density lipoprotein (LDL) receptor–null mice on a Western diet.
Mohamad Navab, G.M. Anantharamaiah, Alan M. Fogelman   +2 more
openaire   +1 more source

High-density Lipoproteins and Apolipoprotein A-I: Potential New Players in the Prevention and Treatment of Lung Disease

Frontiers in Pharmacology, 2016
Apolipoprotein A-I (apoA-I) and high-density lipoproteins (HDL) mediate reverse cholesterol transport out of cells. Furthermore, HDL has additional protective functions, which include anti-oxidative, anti-inflammatory, anti-apoptotic, and vasoprotective
Elizabeth M. Gordon, Debbie M. Figueroa, Amisha V. Barochia, Xianglan Yao, Stewart J. Levine   +4 more
doaj   +1 more source

Insulin Fused to Apolipoprotein A-I Reduces Body Weight and Steatosis in DB/DB Mice

Frontiers in Pharmacology, 2021
Background: Targeting long-lasting insulins to the liver may improve metabolic alterations that are not corrected with current insulin replacement therapies.
Nuria Ardaiz, Nuria Ardaiz, Celia Gomar, Celia Gomar, Marcos Vasquez, Marcos Vasquez, Shirley Tenesaca, Shirley Tenesaca, Myriam Fernandez-Sendin, Myriam Fernandez-Sendin, Claudia Augusta Di Trani, Claudia Augusta Di Trani, Virginia Belsué, Virginia Belsué, Javier Escalada, Javier Escalada, Javier Escalada, Ulrich Werner, Norbert Tennagels, Pedro Berraondo, Pedro Berraondo, Pedro Berraondo   +21 more
doaj   +1 more source

Apolipoprotein A-I and A-I mimetic peptides: a role in atherosclerosis

Journal of Inflammation Research, 2011
Godfrey S Getz, Catherine A ReardonThe University of Chicago, Department of Pathology, Chicago, IL, USAAbstract: Cardiovascular disease remains a major cause of morbidity and mortality in the westernized world.
Getz GS, Reardon CA
doaj  

Levels of apolipoproteins as risk factors for coronary artery disease Níveis de apolipoproteínas como fatores de risco para doença arterial coronariana

Jornal Vascular Brasileiro, 2011
INTRODUCTION: The Saudi population is renowned for their unhealthy diet and physical inactivity. OBJECTIVE:To investigate apolipoproteins B (apo B), A-I (apo A-I) and B/A-I as risk factors that might be associated with increased incidence of the coronary
Mohmed Ashmaig, Khalifa Ashmeik, Atif Ahmed, Samia Sobki, Muheeb Abdulla   +4 more
doaj   +1 more source

Apolipoprotein A-I of primates.

Journal of Lipid Research, 1984
Monkey apoA-I was isolated by ultracentrifugation or immunoprecipitation and analyzed by isoelectric focusing and two-dimensional polyacrylamide gel electrophoresis. The plasma apoA-I of 26 Old World monkeys (12 cynomolgus and 14 rhesus), 40 New World monkeys (8 cebus, 8 squirrel, 8 spider, 8 owl, and 8 marmosets), 6 prosimians (lemurs) and 10 apes (5 ...
R J Nicolosi, V I Zannis
openaire   +3 more sources

Lipid‐Free Apolipoprotein A‐I Reduces Progression of Atherosclerosis by Mobilizing Microdomain Cholesterol and Attenuating the Number of CD131 Expressing Cells: Monitoring Cholesterol Homeostasis Using the Cellular Ester to Total Cholesterol Ratio

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2016
BackgroundAtherosclerosis is a chronic inflammatory disorder whose development is inversely correlated with high‐density lipoprotein concentration. Current therapies involve pharmaceuticals that significantly elevate plasma high‐density lipoprotein ...
Sushma Kaul, Hao Xu, Manal Zabalawi, Elisa Maruko, Brian E. Fulp, Theresa Bluemn, Kristina L. Brzoza‐Lewis, Mark Gerelus, Ranjuna Weerasekera, Rachel Kallinger, Roland James, Yi (Sherry) Zhang, Michael J. Thomas, Mary G. Sorci‐Thomas   +13 more
doaj   +1 more source

Protein Backbone and Average Particle Dynamics in Reconstituted Discoidal and Spherical HDL Probed by Hydrogen Deuterium Exchange and Elastic Incoherent Neutron Scattering

Biomolecules, 2020
Lipoproteins are supramolecular assemblies of proteins and lipids with dynamic characteristics critically linked to their biological functions as plasma lipid transporters and lipid exchangers. Among them, spherical high-density lipoproteins are the most
Valentin Gogonea, Judith Peters, Gary S. Gerstenecker, Celalettin Topbas, Liming Hou, Jérôme Combet, Joseph A. DiDonato, Jonathan D. Smith, Kerry-Anne Rye, Stanley L. Hazen   +9 more
doaj   +1 more source

Apolipoprotein A-I Stimulates Secretion of Apolipoprotein E by Foam Cell Macrophages [PDF]

Journal of Biological Chemistry, 1999
Apolipoprotein A-I (apoA-I) overexpression inhibits atherogenesis in mice, and apolipoprotein E (apoE) secreted by foam cell macrophages may exert antiatherogenic effects within the arterial wall. We hypothesized that interaction between apoA-I and apoE contributed to the antiatherogenic properties of apoA-I, and therefore investigated whether apoA-I ...
D, Rees, T, Sloane, W, Jessup, R T, Dean, L, Kritharides   +4 more
openaire   +2 more sources

HDL regulates the displacement of hepatic lipase from cell surface proteoglycans and the hydrolysis of VLDL triacylglycerol

Journal of Lipid Research, 2003
We have previously shown that hepatic lipase (HL) is inactive when bound to purified heparan sulfate proteoglycans and can be liberated by HDL and apolipoprotein A-I (apoA-I), but not by LDL or VLDL.
Tanya A. Ramsamy, Jonathan Boucher, Robert J. Brown, Zemin Yao, Daniel L. Sparks   +4 more
doaj   +1 more source