Results 211 to 220 of about 123,719 (312)

Proteolytic remodelling of the extracellular matrix by pericytes

open access: yesThe FEBS Journal, EarlyView.
Pericytes are specialised perivascular cells intimately connected with endothelial cells and essential for the maintenance of vascular beds. They contribute to the formation and remodelling of the extracellular matrix by actively secreting proteases and protease inhibitors.
Tina Burkhard   +4 more
wiley   +1 more source

Understanding and addressing resistance to IMiDs immunomodulatory compounds in multiple myeloma

open access: yesThe FEBS Journal, EarlyView.
IMiDs are pivotal in the treatment of multiple myeloma. Mechanisms of resistance comprise cell intrinsic and extrinsic pathways, involving tumour microenvironment, immune cell dysfunction, CRBN‐dependent and independent genetic drivers and epigenetic changes.
Maria‐Cynthia Fuentes‐Lacouture   +3 more
wiley   +1 more source

Angiopoietin‐like protein 3 complete and partial deficiency markedly accelerates apolipoprotein B48 and B100 metabolism in triglyceride‐rich lipoproteins in humans

open access: yesJournal of Internal Medicine, EarlyView.
Abstract Background Angiopoietin‐like protein 3 (ANGPTL3) is a key circulating regulator of triglyceride metabolism and a promising pharmacological target. The physiological consequences of profound ANGPTL3 deficiency can be explored in individuals with inherited loss‐of‐function (LOF) variants, who show reduced lifetime risk of atherosclerotic ...
Marcello Arca   +16 more
wiley   +1 more source

Sleep Improvement for Metabolic Health: A Feasibility Trial of a Digital Sleep Treatment in People With Insomnia and Non‐Diabetic Hyperglycaemia

open access: yesJournal of Sleep Research, EarlyView.
ABSTRACT Insomnia may play a causal role in type 2 diabetes (T2D). Addressing insomnia through cognitive behavioural therapy (CBTi) in people with non‐diabetic hyperglycaemia could potentially reduce the risk of progression to T2D. To inform a future randomised trial, we performed a feasibility study of digital CBT (dCBTi) in individuals at increased ...
Rachel Sharman   +11 more
wiley   +1 more source

Evaluating School‐Based Obesity Prevention Interventions in 6‐ to 12‐Year‐Old Children: A Scoping Review of All Reported Outcomes and Expert Consultation

open access: yesObesity Reviews, EarlyView.
ABSTRACT Introduction This scoping review aims to identify all outcomes reported in school‐based obesity prevention interventions in childhood. It serves as an essential first step towards developing an internationally agreed‐upon Core Outcome Set (COS), which defines what should be measured in all school‐based childhood obesity prevention studies ...
Teatske M. Altenburg   +14 more
wiley   +1 more source

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