Results 81 to 90 of about 31,566,991 (117)

BDNF genotype interacts with motor-function to influence rehabilitation responsiveness post-stroke

Frontiers in Neurology, 2016
Background. Persistent motor impairment is common but highly heterogeneous post-stroke. Genetic polymorphisms, including those identified on the brain derived neurotrophic factor (BDNF) and apolipoprotein E (APOE) genes, may contribute to this ...
Christine T Shiner, Christine T Shiner, Kerrie D Pierce, Angelica G Thompson-Butel, Angelica G Thompson-Butel, Terry eTrinh, Terry eTrinh, Peter R Schofield, Peter R Schofield, Penelope A McNulty, Penelope A McNulty   +10 more
doaj   +1 more source

OPA1 increases the risk of normal but not high tension glaucoma

, 2010
Background Primary open angle glaucoma is a progressive optic neuropathy characterised by the selective loss of retinal ganglion cells, pathological optic disc cupping and visual field defects.
Griffiths, P. G., Birch, M. K., Andrews, R. M., Chinnery, P. F., Hudson, G., Yu-Wai-Man, P., Stewart, J .D.   +6 more
core   +1 more source

P3.27 ASSOCIATION STUDY OF APOE POLYMORPHISMS WITH ESSENTIAL HYPERTENSION IN BULGARIAN PATIENTS

Artery Research, 2013
Apolipoprotein E (ApoE) polymorphism influences lipid metabolism, but its association with essential hypertension (EH) is controversial. The objective of this study was to examine the association between ApoE polymorphisms and EH in Bulgarian population.
R. Tzveova, T. Yaneva, Y. Matrozova, S. Vandeva, G. Naydenova, D. Pendicheva, R. Tarnovska, R. Kaneva, G. Nachev, V. Mitev   +9 more
doaj   +1 more source

APOE, Aβ42, and tau differentially impact cognitive decline in Sporadic, GBA1 and LRRK2 Parkinson’s disease

npj Parkinson's Disease
Cognitive impairment varies across sporadic Parkinson’s disease (PD) and the common genetic subtypes glucocerebrosidase (GBA1) and leucine-rich repeat kinase 2 (LRRK2) PD and is influenced by Apolipoprotein E (APOE) polymorphisms and Alzheimer’s disease (
Ragasudha Botta, Joseph J. Locascio, Rong Ye, Anna E. Goodheart, Stephen N. Gomperts   +4 more
doaj   +1 more source

APOE and LDLR Gene Polymorphisms and Dyslipidemia Tracking. Rio de Janeiro Study

Arquivos Brasileiros de Cardiologia, 2015
Background: Studies show an association between changes in apolipoprotein E (ApoE) and LDLR receptor with the occurrence of dyslipidemia. Objectives: To investigate the association between polymorphisms of the APOE (ε2, ε3, ε4) and LDLR (A370T) genes ...
Rossana Ghessa Andrade de Freitas, Erika Maria Gonçalves Campana, Roberto Pozzan, Andréa Araujo Brandão, Ayrton Pires Brandão, Maria Eliane Campos Magalhães, Dayse Aparecida da Silva   +6 more
doaj   +1 more source

The incidence of liver injury in Uyghur patients treated for TB in Xinjiang Uyghur autonomous region, China, and its association with hepatic enzyme polymorphisms nat2, cyp2e1, gstm1 and gstt1. [PDF]

, 2014
BACKGROUND AND OBJECTIVE: Of three first-line anti-tuberculosis (anti-TB) drugs, isoniazid is most commonly associated with hepatotoxicity. Differences in INH-induced toxicity have been attributed to genetic variability at several loci, NAT2, CYP2E1 ...
Ma, Jinfeng, Xuemei Yao, Mingqin Cao, Merle Corinne, Xia Zhu, Liu Wei, Weidong Wu, Yongguang Li, Jiayi Gu, Ma Jinfeng, Qian Wang, Milligan Paul, Zhu, Xia, Ying Mao, Liu, Wei, Ma Long, Jinfeng Ma, Xiang, Yang, Cao, Mingqin, Ma, Long, Merle, Corinne, Long Ma, Yang Lei, Xiang Yang, Yao Xuemei, Wubuli, Atikaimu, Wu, Weidong, Xin Xiumei, Li, Yongguang, Yang Xiang, Paul Milligan, Xiumei Xin, Lei Yang, Corinne Merle, Zhu Xia, Li Yongguang, Mao Ying, Milligan, Paul, Mao, Ying, Gu, Jiayi, Atikaimu Wubuli, Gu Jiayi, Yao, Xuemei, Wu Weidong, Wang Qian, Yang, Lei, Xin, Xiumei, Wang, Qian, Cao Mingqin, Wubuli Atikaimu, Wei Liu   +50 more
core   +1 more source

Replication by the Epistasis Project of the interaction between the genes for IL-6 and IL-10 in the risk of Alzheimer's disease

Journal of Neuroinflammation, 2009
Background Chronic inflammation is a characteristic of Alzheimer's disease (AD). An interaction associated with the risk of AD has been reported between polymorphisms in the regulatory regions of the genes for the pro-inflammatory cytokine, interleukin-6
Alvarez Victoria, Coto Eliecer, Harrison Rachel, Kehoe Patrick G, Brown Kristelle, Wilcock Gordon K, Heun Reinhard, Kölsch Heike, Schuur Maaike, Aulchenko Yurii S, Lehmann Michael G, Cortina-Borja Mario, Arias-Vásquez Alejandro, Belbin Olivia, Hammond Naomi, van Duijn Cornelia M, Combarros Onofre, Deloukas Panos, Mateo Ignacio, Gwilliam Rhian, Morgan Kevin, Warden Donald R, Smith A David, Lehmann Donald J   +23 more
doaj   +1 more source

Apolipoprotein E E3/E4 genotype is associated with an increased risk of premature coronary artery disease

BMC Cardiovascular Disorders
Objective Dyslipidemia is one of the causes of coronary heart disease (CAD), and apolipoprotein E (APOE) gene polymorphism affects lipid levels. However, the relationship between APOE gene polymorphisms and premature CAD (PCAD, male CAD patients with ...
Youqian Li, Wei Zhong, Changjing Huang, Junyin Peng, Hanlin Li   +4 more
doaj   +1 more source

The APOE paradox: divergent genetic influences on hemorrhagic stroke risk—A meta-analysis

Frontiers in Stroke
BackgroundApolipoprotein E (APOE) regulates lipid metabolism and neuronal repair, yet its alleles show contrasting effects on hemorrhagic stroke (HS) risk.
Manabesh Nath, Astha Rai, Shubham Misra, Pradeep Kumar   +3 more
doaj   +1 more source

Impact of the ApoE Genotype on Coronary Artery Disease and the Incidence of Myocardial Infarction: A Clinical Observational Study

Artery Research
Background This study aimed to investigate the relationships between the expression of apolipoprotein E (APOE) and gene polymorphisms of solute carrier organic anion transporter family member 1B1 (SLCO1B1) with the blood lipid profile and coronary artery
Meng-li Li, Xun Yang, Ning-Jun Zhu, Zhen Wang, Zheng Huang, Ting-ting Fan, Zhang-Jin Zhu   +6 more
doaj   +1 more source