Results 61 to 70 of about 31,566,991 (117)

Elevated endogenous glucagon‐like peptide‐1 as a novel Alzheimer's disease biomarker associated with neuroinflammation and Aβ pathology

General Psychiatry, Volume 39, Issue 5, October 2026.
ABSTRACT Background Alzheimer's disease (AD), a neurodegenerative disorder, is pathologically defined by the accumulation of amyloid‐β (Aβ) plaques, hyperphosphorylated tau tangles and sustained neuroinflammation. Glucagon‐like peptide‐1 (GLP‐1), originally characterised as an incretin hormone, is also expressed endogenously in the brain.
Jianping Li, Chenhui Ji, Jintao Wang, Jinwen Xiao, Haixia Li, Xinyi Xie, Nan Zhi, Yaying Song, Wenwei Cao, Liling Wang, Jieli Geng, Rujing Ren, Gang Wang   +12 more
wiley   +1 more source

Interleukin-8-251T > a, interleukin-1α-889C > t and apolipoprotein e polymorphisms in Alzheimer's disease

Genetics and Molecular Biology, 2011
An inflammatory process has been involved in numerous neurodegenerative disorders such as Parkinson's disease, stroke and Alzheimer's disease (AD). In AD, the inflammatory response is mainly located in the vicinity of amyloid plaques.
Alex Augusto Vendramini, Roger Willian de Lábio, Lucas Trevizani Rasmussen, Nathali Mattiuzo dos Reis, Thais Minett, Paulo Henrique Ferreira Bertolucci, Marcela Augusta de Souza Pinhel, Dorotéia Rossi Silva Souza, Diego Robles Mazzotti, Marília de Arruda Cardoso Smith, Spencer Luiz Marques Payão   +10 more
doaj  

Variants of the microsomal triglyceride transfer protein gene are associated with plasma cholesterol levels and body mass index

Journal of Lipid Research, 2002
The microsomal triglyceride transfer protein (MTP) is required for the assembly and secretion of apolipoprotein B (apoB)-containing lipoproteins from liver and intestine. We set out to study the phenotypic modulation of all common genetic variants in the
Helena Ledmyr, Fredrik Karpe, Björn Lundahl, Margaret McKinnon, Camilla Skoglund-Andersson, Ewa Ehrenborg   +5 more
doaj   +1 more source

Consensus‐Defined Sarcopenic Obesity and a Related Dynapenic Obesity Phenotype in Relation to Early Cognitive Impairment

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 5, October 2026.
ABSTRACT Background Previous studies examining sarcopenic obesity in relation to cognitive function have utilized heterogeneous operational definitions. Some studies have evaluated low muscle strength combined with obesity, more appropriately described as dynapenic obesity, under the broader term sarcopenic obesity.
Mu‐Cyun Wang, Tao‐Chun Peng, Jeng‐Min Chiou, Yen‐Ching Chen, Jen‐Hau Chen   +4 more
wiley   +1 more source

Interleukin-8-251T > a, interleukin-1α-889C > t and apolipoprotein e polymorphisms in Alzheimer's disease

Genetics and Molecular Biology, 2011
An inflammatory process has been involved in numerous neurodegenerative disorders such as Parkinson's disease, stroke and Alzheimer's disease (AD). In AD, the inflammatory response is mainly located in the vicinity of amyloid plaques.
Alex Augusto Vendramini, Roger Willian de Lábio, Lucas Trevizani Rasmussen, Nathali Mattiuzo dos Reis, Thais Minett, Paulo Henrique Ferreira Bertolucci, Marcela Augusta de Souza Pinhel, Dorotéia Rossi Silva Souza, Diego Robles Mazzotti, Marília de Arruda Cardoso Smith, Spencer Luiz Marques Payão   +10 more
doaj  

Apolipoprotein E genotyping variations and their influence on cognitive outcome among idiopathic generalized epileptic patients

Journal of the Arab Society for Medical Research
Background/aim Epilepsy is a brain disorder affecting individuals of all ages. It is one of the most common neurological disorders, affecting about 50 million people globally.
Nancy El-Salhy, Noura R. Eissa, Salma Ragab, Gamil M. Abd-Allah, Sara M. Sayed   +4 more
doaj   +1 more source

Myelin Impairment and Regeneration in the Central Nervous System: Molecular Mechanisms, Diseases, and Prospective Therapeutic Targets

MedComm, Volume 7, Issue 10, October 2026.
Proper myelin formation is crucial for normal neural circuit function, while myelin deficiency can lead to neural circuit dysfunction and cognitive decline, notably in Alzheimer's disease and other central nervous system demyelinating disorders. This review summarizes central myelin's structure and function, demyelination biomarkers and pathological ...
Lihong Huang, Peng Cheng, Guangdong Liu, Yang Xiang, Zhen Hong, Weidong Le   +5 more
wiley   +1 more source

The role of inflammation, oxidative stress and the apolipoprotein E genotype in HIV-associated cognitive impairment: a clinical, biochemical and neuro-imaging study [PDF]

, 2010
Includes abstract.Includes bibliographical references (leaves 113-135).Twenty percent of HIV-infected patients develop HIV-associated neurocognitive disorders (HAND), a spectrum of neurological diseases which includes HIV-associated dementia (HAD), a ...
Mahne, Anna Cecilia
core   +1 more source

TMEM106B is a selective modulator of TDP‐43 pathology in Alzheimer's disease

Alzheimer's &Dementia, Volume 22, Issue 9, September 2026.
Abstract INTRODUCTION Co‐pathologies – including Lewy body, vascular, and TDP‐43 lesions – are common in Alzheimer's disease (AD), contributing to its clinical and pathological heterogeneity. Genetic risk factors may drive mixed pathology presentation, but their influence on the development of specific co‐pathologies remains unclear.
Madison M. Reeves, Anna Calliari, Tiffany W. Todd, Candela Maroto Cidfuentes, Karen Jansen‐West, Mei Yue, Yuping Song, Judith Dunmore, Bailey Rawlinson, Erica Engelberg‐Cook, Michael DeTure, Gregory S. Day, Neill R. Graff‐Radford, Bradley F. Boeve, David S. Knopman, Ronald C. Petersen, Casey N. Cook, Melissa E. Murray, Dennis W. Dickson, Keith A. Josephs, Leonard Petrucelli, Mercedes Prudencio   +21 more
wiley   +1 more source

Apolipoprotein E ɛ3/ɛ4 genotype is associated with premature myocardial infarction: a hospital based retrospective study

BMC Cardiovascular Disorders
Objective To explore the association between apolipoprotein E (APOE) gene polymorphisms and the risk of premature (age of onset: men ≤ 55 years old, women ≤ 65 years old) myocardial infarction (PMI).
Hao Wang, Bin Li, Wenhao Chen, Guoliang Wei, Kehui Chen, Weihong Wang, Yuanliang Liu   +6 more
doaj   +1 more source