Results 61 to 70 of about 45,778 (202)

Can APOE and MTHFR polymorphisms have an influence on the severity of cardiovascular manifestations in Italian Pseudoxanthoma elasticum affected patients?

Molecular Genetics and Metabolism Reports, 2014
Background: The clinical phenotype of Pseudoxanthoma elasticum (PXE) affected patients, although progressive with age, is very heterogeneous, even in the presence of identical ABCC6 mutations, thus suggesting the occurrence of modifier genes.
Federica Boraldi, Sonia Costa, Claudio Rabacchi, Miriam Ciani, Olivier Vanakker, Daniela Quaglino   +5 more
doaj   +1 more source

The genetic association between apolipoprotein E gene polymorphism and Parkinson disease

Medicine, 2018
Objective: Although the relationship between apolipoprotein E (ApoE) gene polymorphisms and the risk of Parkinson disease (PD) has been established, the results were inconsistent and inconclusive. Methods: A comprehensive search examining the association
Jianming Li, Jia Luo, Li Liu, Hui Fu, Liang Tang   +4 more
semanticscholar   +1 more source

APOE‐ε4 carriership and dementia risk over 10 years among Asian American and White older adults

Alzheimer's &Dementia, Volume 22, Issue 7, July 2026.
Abstract INTRODUCTION The Apolipoprotein E ε4 allele (APOE‐ε4) is a well‐established dementia risk factor among non‐Latino White individuals but remains understudied among Asian Americans. We estimated its association with dementia risk among Chinese, Japanese, Filipino, and non‐Latino White older adults in California.
Yingyan Wu, L. Paloma Rojas‐Saunero, Yixuan Zhou, Eleanor Hayes‐Larson, Joseph Oliver Fong, Taylor Mobley, Willa D. Brenowitz, Thomas J. Hoffmann, Kacie D. Deters, Rachel A. Whitmer, Paola Gilsanz, Gilbert C. Gee, Ron Brookmeyer, Elizabeth Rose Mayeda   +13 more
wiley   +1 more source

Polymorphism of PPARG (P12A), APOA1 (G75A), and APOE (C112A and A158C) Genes in Children with Obesity and Arterial Hypertension: A Case-Control Study

Вопросы современной педиатрии, 2018
Background. The genetic nature of a comorbid development of obesity and arterial hypertension (AH) in children is poorly studied. In this regard, it is important to study genes, the polymorphism of which is associated with disturbances in both metabolic ...
Olga P. Kovtun, Margarita A. Ustyuzhanina   +1 more
doaj   +1 more source

Interleukin-8-251T > A, Interleukin-1α-889C > T and Apolipoprotein E polymorphisms in Alzheimer’s disease

Genetics and Molecular Biology, 2010
An inflammatory process has been involved in numerous neurodegenerative disorders such as Parkinson’s disease, stroke and Alzheimer’s disease (AD). In AD, the inflammatory response is mainly located in the vicinity of amyloid plaques.
A. Vendramini, R. W. De Labio, L. Rasmussen, Nathali Mattiuzo dos Reis, T. Minett, P. Bertolucci, Marcela Augusta de Souza Pinhel, D. Souza, D. Mazzotti, M. de Arruda Cardoso Smith, S. Payão   +10 more
semanticscholar   +1 more source

Greater choroid plexus volume is linked to poor sleep, neurodegeneration, and cognitive deficits in older adults: Evidence from the IGNITE Study

Alzheimer's &Dementia, Volume 22, Issue 7, July 2026.
Abstract INTRODUCTION Poor sleep is associated with neurodegenerative disease, but mechanisms are unclear. Greater volume of the choroid plexus (ChP), a brain structure supporting neurotoxic waste clearance, is linked to neurodegeneration and cognitive decline.
Miranda G. Chappel‐Farley, Kelsey R. Sewell, Audrey M. Collins, Cristina Molina‐Hidalgo, Shivangi Jain, Haiqing Huang, Patricio Solis‐Urra, Lauren E. Oberlin, George Grove, Arthur F. Kramer, Edward McAuley, Jeffrey M. Burns, Charles Hillman, Eric D. Vidoni, Bradley P. Sutton, Anna L. Marsland, M. Ilyas Kamboh, Chaeryon Kang, Lu Wan, Kirk I. Erickson, Kristine A. Wilckens   +20 more
wiley   +1 more source

Genetic architecture of the limbic white matter microstructure in aging and Alzheimer's Disease

Alzheimer's &Dementia, Volume 22, Issue 7, July 2026.
Abstract INTRODUCTION Limbic white matter (WM) abnormalities are prevalent in aging and Alzheimer's disease (AD), but genetic drivers are unclear. METHODS In 2614 older adults (mean age ± SD: 73.7 ± 9.8 years; 26% cognitively impaired) from seven harmonized cohorts enriched for cognitive impairment, we quantified free‐water–corrected diffusion MRI ...
Anna S Lorenz, Aditi Sathe, Yisu Yang, Alaina Durant, Yiyang Wu, Michael E. Kim, Chenyu Gao, Nancy R. Newlin, Karthik Ramadass, Praitayini Kanakaraj, Nazirah Mohd Khairi, Zhiyuan Li, Tianyuan Yao, Yuankai Huo, Logan Dumitrescu, Niranjana Shashikumar, Kimberly R. Pechman, Shannon L. Risacher, Lori L. Beason‐Held, Yang An, Konstantinos Arfanakis, Guray Erus, Christos Davatzikos, Mohamad Habes, Di Wang, Duygu Tosun, Arthur W. Toga, Paul M. Thompson, Elizabeth C. Mormino, Panpan Zhang, Kurt Schilling, Marilyn Albert, Walter Kukull, Sarah A. Biber, Bennett A. Landman, Sterling C. Johnson, Barbara Bendlin, Julie Schneider, David A. Bennett, Angela L. Jefferson, Susan M. Resnick, Andrew J. Saykin, Jennifer E. Below, Timothy J. Hohman, Derek B. Archer, Alzheimer's Disease Neuroimaging Initiative (ADNI), The BIOCARD Study Team (BIOCARD), The Alzheimer's Disease Sequencing Project (ADSP)   +47 more
wiley   +1 more source

Interleukin-8-251T > a, interleukin-1α-889C > t and apolipoprotein e polymorphisms in Alzheimer's disease

Genetics and Molecular Biology, 2011
An inflammatory process has been involved in numerous neurodegenerative disorders such as Parkinson's disease, stroke and Alzheimer's disease (AD). In AD, the inflammatory response is mainly located in the vicinity of amyloid plaques.
Alex Augusto Vendramini, Roger Willian de Lábio, Lucas Trevizani Rasmussen, Nathali Mattiuzo dos Reis, Thais Minett, Paulo Henrique Ferreira Bertolucci, Marcela Augusta de Souza Pinhel, Dorotéia Rossi Silva Souza, Diego Robles Mazzotti, Marília de Arruda Cardoso Smith, Spencer Luiz Marques Payão   +10 more
doaj  

Variants of the microsomal triglyceride transfer protein gene are associated with plasma cholesterol levels and body mass index

Journal of Lipid Research, 2002
The microsomal triglyceride transfer protein (MTP) is required for the assembly and secretion of apolipoprotein B (apoB)-containing lipoproteins from liver and intestine. We set out to study the phenotypic modulation of all common genetic variants in the
Helena Ledmyr, Fredrik Karpe, Björn Lundahl, Margaret McKinnon, Camilla Skoglund-Andersson, Ewa Ehrenborg   +5 more
doaj   +1 more source

Evidence of APOE4‐related brain vulnerabilities in verbal memory systems in midlife women

Alzheimer's &Dementia, Volume 22, Issue 7, July 2026.
Abstract INTRODUCTION Women carrying the apolipoprotein E4 (APOE4) allele have a greater risk of Alzheimer's disease (AD) from ages 65‐75 years compared to men, yet the effects of APOE4 on cognitive and neuroimaging outcomes among midlife women remain poorly understood.
Katrina A. Wugalter, Rebecca C. Thurston, Minjie Wu, Howard J. Aizenstein, M. Ilyas Kamboh, Thomas K. Karikari, Pauline M. Maki   +6 more
wiley   +1 more source