Results 71 to 80 of about 45,778 (202)

Interleukin-8-251T > a, interleukin-1α-889C > t and apolipoprotein e polymorphisms in Alzheimer's disease

Genetics and Molecular Biology, 2011
An inflammatory process has been involved in numerous neurodegenerative disorders such as Parkinson's disease, stroke and Alzheimer's disease (AD). In AD, the inflammatory response is mainly located in the vicinity of amyloid plaques.
Alex Augusto Vendramini, Roger Willian de Lábio, Lucas Trevizani Rasmussen, Nathali Mattiuzo dos Reis, Thais Minett, Paulo Henrique Ferreira Bertolucci, Marcela Augusta de Souza Pinhel, Dorotéia Rossi Silva Souza, Diego Robles Mazzotti, Marília de Arruda Cardoso Smith, Spencer Luiz Marques Payão   +10 more
doaj  

Apolipoprotein E genotyping variations and their influence on cognitive outcome among idiopathic generalized epileptic patients

Journal of the Arab Society for Medical Research
Background/aim Epilepsy is a brain disorder affecting individuals of all ages. It is one of the most common neurological disorders, affecting about 50 million people globally.
Nancy El-Salhy, Noura R. Eissa, Salma Ragab, Gamil M. Abd-Allah, Sara M. Sayed   +4 more
doaj   +1 more source

Alzheimer's blood‐based biomarkers, incident dementia, and interactions with age, APOE status, and hormone therapy

Alzheimer's &Dementia, Volume 22, Issue 7, July 2026.
Abstract INTRODUCTION Cognitive impairment among older adults is often due to multiple pathologies and heterogenous risk factors. We assessed whether Alzheimer's blood‐based biomarkers (BBMs) were associated with incident mild cognitive impairment (MCI)/probable dementia, and whether associations were modified by age, apolipoprotein E (APOE), and ...
Michelle M. Mielke, Sarah A. Gaussoin, Ramon Casanova, Lauren A. Latham, JoAnn E. Manson, Charles P. Mouton, Ted K. S. Ng, Stephen R. Rapp, Susan M. Resnick, Bonnie C. Sachs, Nazmus Saquib, Aladdin H. Shadyab, Linda K. McEvoy, Andrea Z. LaCroix, Robert B. Wallace, Mark A. Espeland, Jiu‐Chiuan Chen, Kathleen M. Hayden   +17 more
wiley   +1 more source

ApoE‐ and Cfh‐deficient mice exhibit structural and molecular features of human early–intermediate retinal degeneration

Animal Models and Experimental Medicine, Volume 9, Issue 7, Page 1420-1435, July 2026.
Age‐related macular degeneration (AMD) involves lipid dysregulation and complement overactivation. Here, we characterize a double‐knockout ApoE−/−/Cfh−/− mouse as a model of early–intermediate retinal degeneration. These mice exhibit retinal pigment epithelium thinning, Bruch's membrane thickening, lipid accumulation, enhanced C5b‐9 deposition ...
Sergio Recalde, Maite Moreno Orduña, Jaione Bezunartea, Idoia Belza, Ainara Chas, Laura Fernández‐Sánchez, Nicolás Cuenca Navarro, Alfredo García‐Layana, Patricia Fernández‐Robredo, María Hernández   +9 more
wiley   +1 more source

Precision medicine for atherosclerotic cardiovascular disease: Integrative genomics maps risk loci and AI‐predicted functional consequences

Clinical and Translational Medicine, Volume 16, Issue 7, July 2026.
Genomic SEM of five ASCVD traits in > 3.8 million individuals identified 347 risk variants, including 19 novel loci. Integrating fine‐mapping and TWAS prioritized causal genes and revealed endothelial cell enrichment in vascular tissues. AI modelling shows the DCLRE1B mutation destabilizes the protein, impairing DNA repair and transcription.
Liwan Fu, Xiaodi Han, Qin Liu, Yuquan Wang, Yue‐Qing Hu   +4 more
wiley   +1 more source

Apolipoprotein E E3/E4 genotype is associated with an increased risk of coronary atherosclerosis in patients with hypertension

BMC Cardiovascular Disorders
Objective Apolipoprotein E (APOE) gene polymorphisms were associated with coronary atherosclerosis and hypertension. However, the relationship between APOE polymorphisms and coronary atherosclerosis susceptibility in hypertensive patients is unclear. The
Guoliang Wei, Bin Li, Hao Wang, Li Chen, Wenhao Chen, Kehui Chen, Weihong Wang, Shen Wang, Hui Zeng, Yuanliang Liu, Yue Zeng, Hui Rao   +11 more
doaj   +1 more source

Apolipoprotein E Polymorphisms and Postprandial Triglyceridemia before and after Fenofibrate Treatment in the GOLDN Study

Circulation: Cardiovascular Genetics, 2010
Background—Although much is known about the effect of Apolipoprotein E (APOE) alleles on fasting lipid concentrations, less is known about the effect of APOE alleles on postprandial triglyceridemia or the triglyceride response to fenofibrate. Methods and
M. Irvin, E. Kabagambe, H. Tiwari, L. Parnell, R. Straka, M. Tsai, J. Ordovás, D. Arnett   +7 more
semanticscholar   +1 more source

Relationship Between Central Sensitization and Genetic Polymorphisms—A Case–Control Study in Fibromyalgia

European Journal of Pain, Volume 30, Issue 6, July 2026.
ABSTRACT Background Fibromyalgia is a syndrome characterised by widespread chronic pain, which is believed to be mediated by a state of central sensitisation (CS). Based on the hypothesis that CS itself could have genetic determinants, our aim was to further explore this pathway.
Nicolas Macian, Christian Dualé, Marine Delay, Vincent Leray, Bruno Pereira, Yoan Renaud, Yvonne Gloor, Jules Desmeules, Gisèle Pickering   +8 more
wiley   +1 more source

Multiple molecular-genetic defects in a female with mixed hyperlipoproteinemia and earlyischemic heart disease

Терапевтический архив, 2003
Aim. Analysis of genes of apolipoprotein E (apoE), LDLP receptor and methylentetrahydrofolate reductase (MTHFR) in a female patient with mixed hyperlipoproteinemia (HLP) and early ischemic heart disease (IHD). Material and methods. A patient with a mixed
P P Malyshev, D V Stambolsky, A N Meshkov, Yu V Davydova, V V Kukharchuk   +4 more
doaj  

BDNF genotype interacts with motor-function to influence rehabilitation responsiveness post-stroke

Frontiers in Neurology, 2016
Background. Persistent motor impairment is common but highly heterogeneous post-stroke. Genetic polymorphisms, including those identified on the brain derived neurotrophic factor (BDNF) and apolipoprotein E (APOE) genes, may contribute to this ...
Christine T Shiner, Christine T Shiner, Kerrie D Pierce, Angelica G Thompson-Butel, Angelica G Thompson-Butel, Terry eTrinh, Terry eTrinh, Peter R Schofield, Peter R Schofield, Penelope A McNulty, Penelope A McNulty   +10 more
doaj   +1 more source