Results 51 to 60 of about 31,566,991 (117)

Reduced hippocampal volume in healthy young ApoE4 carriers: an MRI study. [PDF]

, 2012
The E4 allele of the ApoE gene has consistently been shown to be related to an increased risk of Alzheimer's disease (AD). The E4 allele is also associated with functional and structural grey matter (GM) changes in healthy young, middle-aged and older ...
Miller, Julia, Rujescu, D., Lamberton, Franck, David Prvulovic, O'Dwyer, Laurence, Tanner, C., Dan Rujescu, Harald Hampel, Julia Miller, Prvulovic, D., Matura, Silke, Lamberton, F., Hampel, Harald, Laurence O'Dwyer, Prvulovic, David, Matura, S., Scheibe, M., O'Dwyer, L.G., Colby Tanner, Tanner, Colby, Hampel, H., Franck Lamberton, Scheibe, Monika, Silke Matura, Monika Scheibe, Miller, J., Rujescu, Dan   +26 more
core   +3 more sources

Polygenic risk scores for Alzheimer's disease are related to dementia risk in APOE ɛ4 negatives

Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, 2021
Introduction Studies examining the effect of polygenic risk scores (PRS) for Alzheimer's disease (AD) and apolipoprotein E (APOE) genotype on incident dementia in very old individuals are lacking.
Jenna Najar, Sven J. van der Lee, Erik Joas, Hanna Wetterberg, John Hardy, Rita Guerreiro, Jose Bras, Margda Waern, Silke Kern, Henrik Zetterberg, Kaj Blennow, Ingmar Skoog, Anna Zettergren   +12 more
doaj   +1 more source

Cell‐based polygenic risk scores predict clinical progression and prioritize network‐based therapeutic targets in Alzheimer's disease

Alzheimer's &Dementia, Volume 22, Issue 10, October 2026.
Abstract BACKGROUND Late‐onset Alzheimer's disease (AD) exhibits substantial biological heterogeneity. We developed a framework linking cell‐type–specific polygenic risk profiles to precision medicine in AD. METHODS Cell‐based polygenic risk scores (cbPRSs) derived from single‐nucleus RNA‐seq co‐expression networks were evaluated in Alzheimer's Disease
Nathan Sahelijo, Priya Rajagopalan, Lu Qian, Rufuto Rahman, Daniel Goldstein, Sophia I. Thomopoulos, David A. Bennett, Lindsay A. Farrer, Thor D. Stein, Li Shen, Heng Huang, Kwangsik Nho, Andrew J. Saykin, Christos Davatzikos, Paul M. Thompson, Julia TCW, Gyungah R. Jun   +16 more
wiley   +1 more source

Clinical Features of Rapidly Progressive Alzheimer's Disease [PDF]

, 2010
Objective: To characterize clinical features, CSF biomarkers and genetic polymorphisms of patients suffering from a rapidly progressing subtype of Alzheimer's dementia (rpAD).
Meissner, Bettina, Bettina Meissner, Zerr, Inga, Redyk, Katharina, Christian Schmidt, Nico von Ahsen, Kretzschmar, Hans A., Lennart Krack, Schmidt, Christian, Roeber, Sigrun, von Ahsen, Nico, Katharina Redyk, Sigrun Roeber, Hans Kretzschmar, Inga Zerr, Krack, Lennart, Kretzschmar, Hans, Schmidt, Christian D., Krack, Lennart A., Ahsen, Nico von   +19 more
core   +1 more source

Can APOE and MTHFR polymorphisms have an influence on the severity of cardiovascular manifestations in Italian Pseudoxanthoma elasticum affected patients?

Molecular Genetics and Metabolism Reports, 2014
Background: The clinical phenotype of Pseudoxanthoma elasticum (PXE) affected patients, although progressive with age, is very heterogeneous, even in the presence of identical ABCC6 mutations, thus suggesting the occurrence of modifier genes.
Federica Boraldi, Sonia Costa, Claudio Rabacchi, Miriam Ciani, Olivier Vanakker, Daniela Quaglino   +5 more
doaj   +1 more source

Targeting Microglial Transcriptional Reprogramming as a Therapy Strategy for Alzheimer's Disease

BioEssays, Volume 48, Issue 10, October 2026.
Recent human genetic studies highlight the critical role of microglial pathways in Alzheimer's disease, with risk loci enriched in microglia‐specific genes such as SPI1 and MEF2C. Dysregulation of these transcription factors contributes to disease pathogenesis.
Byungwook Kim, Selena S. Wang, Justin R. Kim, Jungsu Kim   +3 more
wiley   +1 more source

Polymorphism of PPARG (P12A), APOA1 (G75A), and APOE (C112A and A158C) Genes in Children with Obesity and Arterial Hypertension: A Case-Control Study

Вопросы современной педиатрии, 2018
Background. The genetic nature of a comorbid development of obesity and arterial hypertension (AH) in children is poorly studied. In this regard, it is important to study genes, the polymorphism of which is associated with disturbances in both metabolic ...
Olga P. Kovtun, Margarita A. Ustyuzhanina   +1 more
doaj   +1 more source

From Genomics to Precision Cardiology: A Comprehensive Review of Clinical Applications and Challenges in Cardiovascular Diseases

Clinical Cardiology, Volume 49, Issue 10, October 2026.
Genomic medicine in cardiovascular care is progressing from established diagnostic applications toward integrated risk prediction, multiomics, and emerging therapeutic strategies. ABSTRACT Background Genomic cardiology is an emerging field integrating genetic, molecular, imaging, and digital health data to improve cardiovascular disease (CVD ...
Neda Mohsen‐Pour, Shiva Esmaeili, Aydin Feyzi, Ali Sharafi, Majid Maleki, Samira Kalayinia   +5 more
wiley   +1 more source

Estudo dos polimorfismos PON1-192 e PON2-311 e atividade da enzima paroxonase em pacientes diabéticos tipo 2 [PDF]

, 2012
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências da Saúde, Programa de Pós-Graduação em Farmácia, Florianópolis, 2004A paroxonase sérica humana (PON) é uma enzima localizada na HDL e está envolvida na detoxificação de ...
Catapan, Elisangela
core  

Apolipoprotein E polymorphisms increase the risk of post-stroke depression

Neural Regeneration Research, 2016
Recent reports have shown that apolipoprotein E (APOE) polymorphisms are involved in neurodegenerative disease. However, it is unclear whether APOE affects post-stroke depression.
Xue-bin Li, Jie Wang, An-ding Xu, Jian-min Huang, Lan-qing Meng, Rui-ya Huang, Jun-li Wang   +6 more
doaj   +1 more source