Results 51 to 60 of about 45,778 (202)

Common Variants rs429358 and rs7412 in APOE Gene Are Not Associated with POAG in a Saudi Cohort

Biology
Adult-onset glaucoma, an age-related neurodegenerative disease, is very prevalent among the elderly Arabs of Saudi origin. This study investigated the association between apolipoprotein E (APOE) gene variants (rs429358 and rs7412) and primary open-angle ...
Altaf A. Kondkar, Tahira Sultan, Taif A. Azad, Tanvir Khatlani, Abdulaziz A. Alshehri, Essam A. Osman, Glenn P. Lobo, Faisal A. Almobarak, Saleh A. Al-Obeidan   +8 more
doaj   +1 more source

Lipoprotein lipase and apoE polymorphisms: relationship to hypertriglyceridemia during pregnancy

Journal of Lipid Research, 2001
Pregnancy is associated with increases in plasma total cholesterol (TC) and triglycerides (TG). Individuals with decreased LPL activity have a mild form of hypertriglyceridemia.
Sandra H. McGladdery, Jiri J. Frohlich
doaj   +1 more source

Amplification refractory mutation system polymerase chain reaction versus optimized polymerase chain reaction restriction-fragment length polymorphism for apolipoprotein E genotyping of majorly depressed patients

Molecular Medicine Reports, 2015
Major depressive disorder (MDD) is a prevalent, debilitating mood disorder that has been associated with several genetic polymorphisms. One such polymorphism, namely that of apolipoprotein E (APOE), has three allelic forms (ε2, ε3 and ε4) that encode for six unique isoforms of the APOE protein.
Hongmin, You, Jin, Chen, Jingjing, Zhou, Hua, Huang, Junxi, Pan, Ziye, Wang, Lin, Lv, Lujun, Zhang, Juan, Li, Bin, Qin, Yongtao, Yang, Peng, Xie   +11 more
openaire   +3 more sources

The role of polygenic risk in Alzheimer's disease prediction for African Americans

Alzheimer's &Dementia, Volume 22, Issue 8, August 2026.
Abstract INTRODUCTION African Americans (AAs) face a higher risk of Alzheimer's disease and related dementias (ADRD) than European Americans (EUs), yet the utility of polygenic risk scores (PRS) in AAs remains underexplored. METHODS A standardized dementia PRS was evaluated in the Chicago Health and Aging Project (n = 4336; 61% AA) for associations ...
Christina G. Hutten, Todd Beck, Denis Evans, Kumar B. Rajan   +3 more
wiley   +1 more source

CSF fibrinogen predicts longitudinal Tau accumulation in cognitively unimpaired older adults

Alzheimer's &Dementia, Volume 22, Issue 8, August 2026.
Abstract INTRODUCTION Blood–brain barrier (BBB) dysfunction is an early feature of Alzheimer's disease (AD). Fibrinogen represents a sensitive marker of BBB leakage, but whether it modifies longitudinal tau progression in cognitively unimpaired (CU) individuals remains unknown.
Christos Panagiotis Lisgaras, Tovia Jacobs, Luisa Figueredo, Elizabeth Pirraglia, Caleb H Radtke, Jonah N Keller, Nikolaos Karvelas, Jennifer Bernal, Joaquin Ruiz, Henrik Zetterberg, Lidia Glodzik, Mony J de Leon, Laura Beth McIntire, Allal Boutajangout, Thomas Wisniewski, Jaime Ramos‐Cejudo, Daniel Alcolea, Sandra Giménez, Juan Fortea, Katerina Akassoglou, Fanny M Elahi, Ricardo S Osorio   +21 more
wiley   +1 more source

Apolipoproteins AI/B/E gene polymorphism and their plasma levels in patients with coronary artery disease in a tertiary care-center of Eastern India

Indian Heart Journal, 2013
Aim: The present study was designed to investigate whether the three-apolipoprotein (AI, B, E) gene polymorphisms were related to alter their plasma protein levels and hence associated to coronary artery disease (CAD). Methods: We determined distribution
Santanu Biswas, Pradip K. Ghoshal, Bhubaneswar Halder, Kajal Ganguly, Arup DasBiswas, Nripendranath Mandal   +5 more
doaj   +1 more source

The association of genetic polymorphisms with neuroconnectivity in breast cancer patients

Scientific Reports, 2021
Genetic polymorphisms in select genes, including APOE (apolipoprotein E), COMT (Catechol-O-Methyltransferase), MDR1 (multi-drug resistance 1), BDNF (brain derived neurotrophic factor), and GST (glutathione-S-transferase), have been associated with ...
Rebecca A. Harrison, Vikram Rao, Shelli R. Kesler   +2 more
doaj   +1 more source

APOE and genetic risk variants influence Alzheimer's disease onset in carriers of an extra copy of APP, with and without Down syndrome

Alzheimer's &Dementia, Volume 22, Issue 8, August 2026.
Abstract INTRODUCTION An extra copy of the amyloid precursor protein (APP) gene causes autosomal dominant Alzheimer's disease (AD) and AD in Down syndrome (DS), but the factors underlying variability in age at onset (AAO) remain unclear. We investigated whether sporadic AD risk variants modify AAO. METHODS We analyzed clinical and genetic data from 100
Joan Groeneveld, Danna Perlaza, Clàudia Olivé, Lou Grangeon, Niccolo Tesi, Aude Nicolas, Chenyang Jiang, Itziar de Rojas, David Wallon, Stéphane Rousseau, Marta Rovira, Diego Real de Asúa, Fernando Moldenhauer, Ruihao Mu, Kévin Cassinari, Aline Zarea, Joaquim Aumatell Escabias, Jean‐Charles Lambert, Yolande A. L. Pijnenburg, Marc Hulsman, Everard G. B. Vijverberg, Johannes Levin, Mathias Jucker, Eric McDade, Juan Fortea, Henne Holstege, Flora H. Duits, Lisa Vermunt, Maulikkumar Patel, Matthew Johnson, Alan E. Renton, Alison M. Goate, Carlos Cruchaga, Cyril Pottier, Maria Victoria Fernandez, Olivia Belbin, Gael Nicolas, Oriol Dols‐Icardo, Sven J. van der Lee, Dominantly Inherited Alzheimer Network   +39 more
wiley   +1 more source

Polygenic risk scores for Alzheimer's disease are related to dementia risk in APOE ɛ4 negatives

Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, 2021
Introduction Studies examining the effect of polygenic risk scores (PRS) for Alzheimer's disease (AD) and apolipoprotein E (APOE) genotype on incident dementia in very old individuals are lacking.
Jenna Najar, Sven J. van der Lee, Erik Joas, Hanna Wetterberg, John Hardy, Rita Guerreiro, Jose Bras, Margda Waern, Silke Kern, Henrik Zetterberg, Kaj Blennow, Ingmar Skoog, Anna Zettergren   +12 more
doaj   +1 more source

Risk Factors for Cardiovascular Disease: Epidemiology, Screening, Prevention, and Therapeutic Interventions

MedComm, Volume 7, Issue 8, August 2026.
Cardiovascular disease arises from lifelong accumulation of traditional and emerging risk factors that converge on shared pathophysiological pathways, leading to diverse clinical outcomes, and can be mitigated through integrated screening, prevention, and precision therapies. ABSTRACT Cardiovascular diseases (CVDs) remain the leading cause of morbidity
Mowei Kong, Zaiyong Zheng, Min Huang, Shengyu Huang, Xingwei Zhao, Yang Yu, Chunxiang Zhang   +6 more
wiley   +1 more source