Results 41 to 50 of about 45,778 (202)
Mapping Causal Biology: Mendelian Randomization in the Era of Big Data
Med Research, EarlyView.Mendelian randomization (MR) leverages genetic variants to mitigate confounding biases in causal inference. This review systematically maps MR's methodological evolution, highlights its expanding applications in epidemiology and drug target validation, and outlines future directions for overcoming current biases through dynamic, multi‐omics, and cross ...
Xuanlu Shen +10 more
wiley +1 more source
Genetic Risk Factors for Longitudinal Changes in Structural MRI in Former Organolead Workers
Journal of Aging Research, 2011 This study examined associations between polymorphisms in three genes, apolipoprotein E (APOE), angiotensin converting enzyme (ACE), and vitamin D receptor (VDR), and longitudinal change in brain volumes and white matter lesions (WML) as well as effect ...
Bryan D. James +5 more
doaj +1 more source
World Journal of Surgical Oncology, 2022 Background Human apolipoprotein E (APOE) polymorphisms are attributable to the presence of three common alleles, namely, ε2, ε3, and ε4, which generate six genotypes, viz, E2/E2, E2/E3, E3/E3, E3/E4, E4/E4, and E2/E4.
Caiyan Gan +4 more
doaj +1 more source
Lipids in Health and Disease, 2015 Apolipoprotein E (ApoE) participates in lipoprotein metabolism and immune regulation. This study assessed association between ApoE polymorphisms with hyperuricemia and uric acid metabolism in Uygur men, Xinjiang, China.
Yuping Sun +10 more
semanticscholar +1 more source
Alzheimer's &Dementia: Behavior &Socioeconomics of Aging, Volume 2, Issue 3, September 2026.Abstract INTRODUCTION Early life adversities have been linked to negative health outcomes, though findings on their potential impact on cognition in older age are mixed. We investigated associations between early adversity and cognitive outcomes (baseline and decline) in older Latino adults, and cardiovascular health's impact on significant ...
Daisy T. Noriega‐Makarskyy +5 more
wiley +1 more source
BMC Medical Genetics, 2008 Background There is increasing evidence indicating that genes involved in certain metabolic processes of cardiovascular diseases may be of particular influence in people with low body weight at birth. We examined whether the apolipoprotein (APO) E, APOC3
Fuentes Miguel +11 more
doaj +1 more source
Genetic association of apolipoprotein E polymorphisms with inflammatory bowel disease.
World Journal of Gastroenterology, 2015 AIM To study the association of apolipoprotein E (APOE) polymorphisms with the susceptibility of inflammatory bowel disease (IBD) in Saudi patients. METHODS APOE genotyping was performed to evaluate the allele and genotype frequencies in 378 Saudi ...
E. S. Al-Meghaiseeb +6 more
semanticscholar +1 more source
High‐density mutation tracks are associated with proton‐beam irradiation patterns in Sorghum bicolor
The Plant Genome, Volume 19, Issue 3, September 2026.Abstract Induced mutagenesis is a cornerstone of crop functional genomics, yet the extent to which distinct radiation sources reshape the spatial distribution of mutations remains difficult to evaluate in reduced‐representation datasets. Here, we analyze a published genotyping‐by‐sequencing (GBS) panel (192,040 loci) to compare proton‐beam and gamma ...
Ezekiel Ahn +6 more
wiley +1 more source
Journal of Lipid Research, 2006 The common apolipoprotein E (apoE) gene (APOE) ɛ2/ɛ3/ɛ4 polymorphism explains part of serum lipid variation, and polymorphisms in the APOE promoter region have been proposed to participate in the regulation of serum lipid levels within the most common ...
Leena E. Viiri +10 more
doaj +1 more source
Alzheimer's &Dementia, Volume 22, Issue 8, August 2026.Abstract INTRODUCTION Genome‐wide association studies (GWAS) have identified 80+ genetic loci associated with Alzheimer's disease (AD), enabling the development of polygenic risk scores (PRS). However, the predictive accuracy of PRS in diverse populations remains low.
Meri Okorie +9 more
wiley +1 more source