Results 41 to 50 of about 31,566,991 (117)

Relations of APOE promoter polymorphisms to LDL cholesterol and markers of subclinical atherosclerosis in young adults

Journal of Lipid Research, 2006
The common apolipoprotein E (apoE) gene (APOE) ɛ2/ɛ3/ɛ4 polymorphism explains part of serum lipid variation, and polymorphisms in the APOE promoter region have been proposed to participate in the regulation of serum lipid levels within the most common ...
Leena E. Viiri, Olli T. Raitakari, Heini Huhtala, Mika Kaähoänen, Riikka Rontu, Markus Juonala, Nina Hutri-Kaähoänen, Jukka Marniemi, Jorma S.A. Viikari, Pekka J. Karhunen, Terho Lehtimaäki   +10 more
doaj   +1 more source

SPG4 and Dementia: Expanding the Clinical Spectrum

Annals of Clinical and Translational Neurology, Volume 13, Issue 10, Page 2002-2016, October 2026.
ABSTRACT Objective Hereditary spastic paraplegia (HSP) is a group of disorders characterized by progressive spasticity and lower limb weakness, with mutations in SPG4/SPAST being the most common cause. Detailed studies and clinical and molecular comparisons across different populations are missing.
Emanuele Panza, Arun Meyyazhagan, Eliseo Picchi, Gustavo Ribas, Ingrid Faber, Ryosuke Miyamoto, Preethi Basavaraju, Paolo Eusebi, Haripriya Kuchi Bhotla, Mario Stasi, Fabrizio Gaudiello, Francesco Patti, Filippo Maria Santorelli, Marcondes Cavalcante França Jr, José Luiz Pedroso, Orlando Graziani Povoas Barsottini, Hélio Afonso Ghizoni Teive, Peter Henry St George‐Hyslop, Toshitaka Kawarai, Antonio Orlacchio   +19 more
wiley   +1 more source

Genetic variants in lipid metabolism are independently associated with multiple features of the metabolic syndrome [PDF]

, 2011
Background Our objective was to find single nucleotide polymorphisms (SNPs), within transcriptional pathways of glucose and lipid metabolism, which are related to multiple features of the metabolic syndrome (MetS).
Boer, J.M., Dollé Martijn ET, Boer Jolanda MA, Feskens Edith JM, Martijn ET Dollé, Edith JM Feskens, Imholz, S., Feskens, E.J.M., Sandra Imholz, Povel, C.M., Cécile M Povel, Jolanda MA Boer, Imholz Sandra, Povel Cécile M, Dolle, M.E.   +14 more
core   +1 more source

Common Variants rs429358 and rs7412 in APOE Gene Are Not Associated with POAG in a Saudi Cohort

Biology
Adult-onset glaucoma, an age-related neurodegenerative disease, is very prevalent among the elderly Arabs of Saudi origin. This study investigated the association between apolipoprotein E (APOE) gene variants (rs429358 and rs7412) and primary open-angle ...
Altaf A. Kondkar, Tahira Sultan, Taif A. Azad, Tanvir Khatlani, Abdulaziz A. Alshehri, Essam A. Osman, Glenn P. Lobo, Faisal A. Almobarak, Saleh A. Al-Obeidan   +8 more
doaj   +1 more source

Lipoprotein lipase and apoE polymorphisms: relationship to hypertriglyceridemia during pregnancy

Journal of Lipid Research, 2001
Pregnancy is associated with increases in plasma total cholesterol (TC) and triglycerides (TG). Individuals with decreased LPL activity have a mild form of hypertriglyceridemia.
Sandra H. McGladdery, Jiri J. Frohlich
doaj   +1 more source

Novel genetic profile linked to cognitive decline in Hispanics/Latinos

Alzheimer's &Dementia, Volume 22, Issue 10, October 2026.
Abstract BACKGROUND The APOE ε4 allele has weaker association with ADRD outcomes in Hispanic/Latino populations compared to non‐Hispanic White and East Asian populations. METHODS We used whole‐genome sequencing data from 13,025 Hispanic/Latino adults to infer population groups (clusters) from short DNA sequences at the APOE gene region.
Yana Hrytsenko, Yogesh Purushotham, Zhirou Li, Carmen R Isasi, Wassim Tarraf, Alberto R Ramos, Martha L Daviglus, Humberto Parada Jr., Brian W Spitzer, Mariko Isshiki, Srilakshmi M Raj, Charles DeCarli, Hector M González, Myriam Fornage, Tamar Sofer   +14 more
wiley   +1 more source

Integrative prediction of Alzheimer's disease and related dementias using multi‐omics aging clocks and genetic data

Alzheimer's &Dementia, Volume 22, Issue 10, October 2026.
Abstract INTRODUCTION We tested whether combining Alzheimer's disease and related dementias (ADRD) polygenic risk scores (PRS) with biological aging markers improves ADRD risk prediction. METHODS In 16,215 UK Biobank (UKB) participants free of ADRD at baseline (median follow‐up: 10.08 years), 397 incident diagnoses were identified.
Shayan Mostafaei, Karolina Gustavsson, Hampus Hagelin, Jonathan K. L. Mak, Trung Nghia Vu, Ida K. Karlsson, Sara Hägg   +6 more
wiley   +1 more source

Apolipoproteins AI/B/E gene polymorphism and their plasma levels in patients with coronary artery disease in a tertiary care-center of Eastern India

Indian Heart Journal, 2013
Aim: The present study was designed to investigate whether the three-apolipoprotein (AI, B, E) gene polymorphisms were related to alter their plasma protein levels and hence associated to coronary artery disease (CAD). Methods: We determined distribution
Santanu Biswas, Pradip K. Ghoshal, Bhubaneswar Halder, Kajal Ganguly, Arup DasBiswas, Nripendranath Mandal   +5 more
doaj   +1 more source

The association of genetic polymorphisms with neuroconnectivity in breast cancer patients

Scientific Reports, 2021
Genetic polymorphisms in select genes, including APOE (apolipoprotein E), COMT (Catechol-O-Methyltransferase), MDR1 (multi-drug resistance 1), BDNF (brain derived neurotrophic factor), and GST (glutathione-S-transferase), have been associated with ...
Rebecca A. Harrison, Vikram Rao, Shelli R. Kesler   +2 more
doaj   +1 more source

Clusterin is enriched in plaque‐associated astrocytes and localizes to synapses in Alzheimer's disease

Alzheimer's &Dementia, Volume 22, Issue 10, October 2026.
Abstract INTRODUCTION The clusterin gene (CLU) is a top genome‐wide association studies (GWAS) risk locus for Alzheimer's disease (AD) and elevated clusterin levels have been reported in AD biofluids and brain tissue. Despite growing interest in clusterin as a biomarker and therapeutic target, its cellular and subcellular localization in the human ...
Robert A. J. Byrne, Aurora Veteleanu, Hannah L. Cramp, Olivia G. Bacon, Kirsten L. Baillie, Matthew Bright, Rebekah S. Cooke, Gareth D. Fenn, Mariana Flores Castelán, Kok Yung Lee, Wioleta M. Zelek, B. Paul Morgan, Nikoleta Daskoulidou   +12 more
wiley   +1 more source