Results 31 to 40 of about 31,566,991 (117)

Quantification of apolipoprotein E receptors in human brain-derived cell lines by real-time polymerase chain reaction [PDF]

, 2004
Apolipoprotein (apo) E4 is a risk factor for Alzheimer's disease (AD) and other neurodegenerative diseases, compared to wild-type apoE3. The mechanism(s) is unknown.
Owen, JS, Everett, D M, Murdock, P R, Everett, DM, Murdock, PR, Owen, J S, Dingwall, C, Thilakawardhana, S   +7 more
core   +1 more source

Endothelial nitric oxide synthase Glu 298 Asp (G894T) and Apolipoprotein E gene polymorphism as possible risk factors for coronary heart disease among Egyptians

The Egyptian Heart Journal, 2018
In Egypt, The prevalence of chronic heart disease (CHD) is 8.3%. It is the principal cause of death and is responsible for 22% of total mortality. The age-adjusted mortality rate is 174 per 100,000 of population.
Sherif Arafa, Sherehan Abdelsalam, Abdel-Hady El-Gilany, Youssef Mohamed Mosaad, Adel Abdel-Ghaffar   +4 more
doaj   +1 more source

Polymorphisms of the apolipoprotein E gene affect response to atorvastatin therapy in acute ischemic stroke

Frontiers in Cardiovascular Medicine, 2022
BackgroundPolymorphisms of the apolipoprotein E (APOE) gene are related to the efficacy of statin therapy. The biological functions of the APOE subtypes determine the metabolism of blood plasma lipids and the progression of atherosclerosis.
QianQian Bi, XiaoYu Zhou, YanQin Lu, Wang Fu, YongPeng Wang, Feng Wang, Jue Wang   +6 more
doaj   +1 more source

Bidirectional Pathological Axis Between Alzheimer's Disease and Circadian Rhythm Disturbance: Mechanisms and Therapeutic Strategies

iNew Medicine, EarlyView.
This graphical abstract illustrates a bidirectional vicious cycle between Alzheimer’s disease (AD) and circadian rhythm disturbance (CRD). On the one hand, AD pathology, including amyloid‐β (Aβ) plaque deposition and tau hyperphosphorylation, may damage the suprachiasmatic nucleus (SCN) and disrupt melatonin signaling, leading to sleep fragmentation ...
Jiajia Qin, Xianfeng Yu, Yayu Wang, Xiaohan Song, Yuehua Wang, Zhixin Wang, Wei Miao, Xudong Yang, Jiajia Zhu, Xiaoqun Zhu, Maria‐Trinidad Herrero   +10 more
wiley   +1 more source

Effect of Apolipoprotein E epsilon 4 on the association between health behaviors and cognitive function in late midlife [PDF]

, 2010
The extent to which the effect of risk factors on cognitive ageing is dependent on APOE epsilon 4 remains unclear. The objective of this study is to examine whether APOE epsilon 4 allele modifies the association between health behaviors and cognition in ...
Kumari, Meena, Singh-Manoux, Archana, Kivimaki Mika, Séverine Sabia, Sabia, Séverine, Mika Kivimaki, Kivimaki, Mika, Sabia Séverine, Kivimaki, M, Singh-Manoux Archana, Archana Singh-Manoux, Kumari Meena, Martin J Shipley, Meena Kumari, Singh-Manoux, A, Shipley, MJ, Shipley Martin J, Sabia, S, Kumari, M, Shipley, Martin   +19 more
core   +1 more source

Genetic Risk Factors for Longitudinal Changes in Structural MRI in Former Organolead Workers

Journal of Aging Research, 2011
This study examined associations between polymorphisms in three genes, apolipoprotein E (APOE), angiotensin converting enzyme (ACE), and vitamin D receptor (VDR), and longitudinal change in brain volumes and white matter lesions (WML) as well as effect ...
Bryan D. James, Brian Caffo, Walter F. Stewart, David Yousem, Christos Davatzikos, Brian S. Schwartz   +5 more
doaj   +1 more source

Effects of APOE gene ε4 allele on serum lipid profiles and risk of cardiovascular disease and tumorigenesis in southern Chinese population

World Journal of Surgical Oncology, 2022
Background Human apolipoprotein E (APOE) polymorphisms are attributable to the presence of three common alleles, namely, ε2, ε3, and ε4, which generate six genotypes, viz, E2/E2, E2/E3, E3/E3, E3/E4, E4/E4, and E2/E4.
Caiyan Gan, Yinmei Zhang, Fei Liang, Xuemin Guo, Zhixiong Zhong   +4 more
doaj   +1 more source

Periodontitis and metabolic dysfunction‐associated steatotic liver disease

Periodontology 2000, EarlyView.
Abstract Objective Periodontitis is a chronic inflammatory disease with systemic effects that extend beyond the oral cavity and contribute to systemic immune and metabolic dysregulation. Chronic liver diseases, particularly metabolic dysfunction‐associated steatotic liver disease (MASLD) and its progressive phenotypes, have emerged as major global ...
Rafael Scaf de Molon, Erica Dorigatti de Avila, Davi da Silva Barbirato, Mariana Fampa Fogacci, Jamil Awad Shibli, Anton Sculean, Alpdogan Kantarci   +6 more
wiley   +1 more source

Birth weight and blood lipid levels in Spanish adolescents: Influence of selected APOE, APOC3 and PPARgamma2 gene polymorphisms. The AVENA Study

BMC Medical Genetics, 2008
Background There is increasing evidence indicating that genes involved in certain metabolic processes of cardiovascular diseases may be of particular influence in people with low body weight at birth. We examined whether the apolipoprotein (APO) E, APOC3
Fuentes Miguel, Nova Esther, Martí Amelia, González-Lamuño Domingo, Moreno Luis A, Ortega Francisco B, Labayen Idoia, Ruiz Jonatan R, Redondo-Figuero Carlos, Martínez J Alfredo, Sjöström Michael, Castillo Manuel J   +11 more
doaj   +1 more source

Hypocholesterolemia in liver and cardiovascular disease: Friend or foe?

Journal of Internal Medicine, Volume 300, Issue 5, Page 572-589, November 2026.
Abstract Hypocholesterolemia is perceived as benign given its association with lower cardiovascular risk. However, genetic and epidemiological evidence indicates that persistently low levels of low‐density lipoprotein cholesterol (LDL‐C) and apolipoprotein B (ApoB) arise from distinct biological mechanisms with different hepatic implications ...
Valentina Flagiello, Emelie Barreby, Umberto Vespasiani‐Gentilucci, Stefano Romeo   +3 more
wiley   +1 more source