Results 31 to 40 of about 45,778 (202)

Presence of the apolipoprotein E-ε4 allele is associated with an increased risk of sepsis progression

Scientific Reports, 2020
Growing evidence indicated that single nucleotide polymorphisms (SNPs) in the apolipoprotein E (APOE) gene are related to increase the risk of many inflammatory-related diseases.
Yiming Shao, Tian Zhao, Wenying Zhang, Junbing He, Furong Lu, Yujie Cai, Zhipeng Lai, Ning Wei, Chunmei Liang, Li-zhen Liu, Yuan Hong, Xiao-Jing Cheng, Jia Li, Pei Tang, Weihao Fan, Mingqian Ou, Jingqi Yang, Yansong Liu, Lili Cui   +18 more
semanticscholar   +1 more source

RELATIONSHIP OF APOLIPOPROTEIN A-1 GENE POLYMORPHISM WITH SOME GROWTH TRAITS OF COMMON CARP (CYPRINUS CARPIO L .)

The Iraqi Journal of Agricultural science
The study was conducted to investigate the relationship between the polymorphisms of A, B, C, D and E of the apolipoprotein A-1 (ApoA-1) gene with some traits (daily and total weight gain rate and feed conversion rate and efficiency) in 70 samples of ...
Othman M. Abdulmajeed, Mohammad S. Al-Khshali, Ahmed W. Al Ameri   +2 more
doaj   +1 more source

Preliminary evidence for an association between LRP-1 genotype and body mass index in humans. [PDF]

PLoS ONE, 2012
The LDL receptor-related protein-1 gene (LRP-1) has been associated with obesity in animal models, but no such association has yet been reported in humans.
Alexis C Frazier-Wood, Edmond K Kabagambe, Ingrid B Borecki, Hemant K Tiwari, Jose M Ordovas, Donna K Arnett   +5 more
doaj   +1 more source

Apolipoprotein E polymorphisms are associated with ischemic stroke susceptibility in a Northwest China Han population

Bioscience Reports, 2017
Ischemic stroke (IS), the leading neurology cause of death and disability worldwide, is influenced by gene polymorphisms. To explore the association between IS and Apolipoprotein E (APOE) gene polymorphisms, a case–control study containing 513 IS ...
Li-li Zhao, G. Su, Li-xia Chen, Qi Yan, Xue-ping Wang, W. Yuan, Lei Wang, Zhen-chang Zhang   +7 more
semanticscholar   +1 more source

Monitoring pharmacodynamic and molecular drug targets in liquid biopsy: Exploratory study in liver cancer with modelling of EGFR Receptor engagement

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim Liquid biopsy is minimally invasive (compared with tissue biopsy) and has previously been used to generate systems data regarding drug elimination via hepatic enzymes and transporters. This study extends quantitative assessment of systems parameters in liquid biopsy to pharmacodynamic (PD) and disease markers relevant to cancer development
Zubida M. Al‐Majdoub, Armin Sepp, Amin Rostami‐Hodjegan, Brahim Achour   +3 more
wiley   +1 more source

Polymorphisms in the genes of citohrom oxidase P450 2D6 (CYP2D6), paraoxonase 1 (PON1) and apolipoproteine E (APOE) as risk factors for Parkinson's disease [PDF]

Vojnosanitetski Pregled, 2007
Background/Aim. The presence of Parkinson's disease (PD) among the members of a family is a clear indication of the significance of genetics in its development.
Đurić Gordana, Svetel Marina, Illarioškin Nikolaevič Sergej, Dragađević Nataša, Gavrilović Jelena, Kostić Vladimir S.   +5 more
doaj   +1 more source

Strategies and mechanisms of precision genome engineering: From gene editing to genome writing

iMetaOmics, EarlyView.
In this review, we examined the progression of genome manipulation from stochastic nuclease‐mediated cutting toward precise editing and programmable genome writing. We discussed tools like multi‐kilobase RNA‐guided integrators and Artificial Intelligence (AI)‐designed effectors and showed how these advances enable researchers to treat genomes as ...
Kerui Huang, Jianhong Tian, Wenyan Zhao, Siqin Zhang, Lixuan Xiang, Meiqing Yang, Lu Liu, Yazhou Huang, Ningyun Zhang, Lei Sun, Peng Xie, Nanyu Kuang, Hong Zhou, Chengfeng Qiu, Jun Yan, Xiaocheng Jiang, Qiang Tu, Yun Wang, Haoliang Hu, Youming Zhang   +19 more
wiley   +1 more source

Endothelial nitric oxide synthase Glu 298 Asp (G894T) and Apolipoprotein E gene polymorphism as possible risk factors for coronary heart disease among Egyptians

The Egyptian Heart Journal, 2018
In Egypt, The prevalence of chronic heart disease (CHD) is 8.3%. It is the principal cause of death and is responsible for 22% of total mortality. The age-adjusted mortality rate is 174 per 100,000 of population.
Sherif Arafa, Sherehan Abdelsalam, Abdel-Hady El-Gilany, Youssef Mohamed Mosaad, Adel Abdel-Ghaffar   +4 more
doaj   +1 more source

Polymorphisms of the apolipoprotein E gene affect response to atorvastatin therapy in acute ischemic stroke

Frontiers in Cardiovascular Medicine, 2022
BackgroundPolymorphisms of the apolipoprotein E (APOE) gene are related to the efficacy of statin therapy. The biological functions of the APOE subtypes determine the metabolism of blood plasma lipids and the progression of atherosclerosis.
QianQian Bi, XiaoYu Zhou, YanQin Lu, Wang Fu, YongPeng Wang, Feng Wang, Jue Wang   +6 more
doaj   +1 more source

Genetic assessment of apolipoprotein E polymorphism and PRNP genotypes in rapidly progressive dementias in Pakistan

Prion
Rapidly progressive dementias (RPDs) are a type of fatal dementias that cause rapid progression of neuronal dysfunction. This study aimed to assess the prevalence of APOE genotypes (ε2, ε3, ε4) and PRNP mutations (E200K, M129V) in the general population of Pakistan because of their association with RPDs, including Rapidly Progressive Alzheimer’s ...
Urwah Rasheed, Minahil Khalid, Aneeqa Noor, Umar Saeed, Rizwan Uppal, Saima Zafar   +5 more
openaire   +5 more sources