Results 11 to 20 of about 45,778 (202)
Association of ApoE gene polymorphisms with serum lipid levels and the risk of type 2 diabetes mellitus in the Chinese Han population of central China [PDF]
PeerJ, 2023 Background Apolipoprotein E (ApoE) is involved in lipid transformation and metabolism. Although some studies have examined the association between ApoE polymorphisms and the risk of type 2 diabetes mellitus (T2DM), the findings differ depending on the ...
Yali Zeng +5 more
doaj +2 more sources
International Journal of Hypertension, 2022 Objective. One of the causes of hypertension is a genetic factor. The purpose of this study was to look at the relationship between apolipoprotein E (APOE) and methylenetetrahydrofolate reductase (MTHFR) polymorphisms and essential hypertension in the ...
Hui Rao +3 more
doaj +1 more source
Lipids in Health and Disease, 2020 Background Apolipoprotein E (ApoE) and solute carrier organic anion transporter family member 1B1 (SLCO1B1) regulate lipid metabolism. However, the relationship between genetic polymorphisms of APOE and SLCO1B1 and cerebral infarction (CI) remains ...
Heming Wu +4 more
doaj +1 more source
Journal of Diabetes Research, 2021 Background. The apolipoprotein E (APOE) gene polymorphisms have been intensively studied in patients with type 2 diabetes mellitus (T2DM) and ischemic stroke (IS) in recent years. However, it is unclear whether APOE gene polymorphisms are correlated with
Na Wang +7 more
doaj +1 more source
Development of a Melting Curve-Based Allele-Specific PCR of Apolipoprotein E (APOE) Genotyping Method for Genomic DNA, Guthrie Blood Spot, and Whole Blood. [PDF]
PLoS ONE, 2016 Genetic polymorphisms of apolipoprotein E (APOE) are associated with various health conditions and diseases, such as Alzheimer's disease, cardiovascular diseases, type 2 diabetes, etc.
Chia-Hsiang Chen
doaj +1 more source
GenoRisk: A polygenic risk score for Alzheimer's disease
Alzheimer’s & Dementia: Translational Research & Clinical Interventions, 2021 Introduction Recent clinical trials are considering inclusion of more than just apolipoprotein E (APOE) ε4 genotype as a way of reducing variability in analysis of outcomes.
Samuel P. Dickson +10 more
doaj +1 more source
Biomédica: revista del Instituto Nacional de Salud, 2004 Varios estudios han demostrado la asociación de los polimorfismos de la apolipoproteína E (APO-E) con la osteoporosis, especialmente, la APO-E 4. Para analizar los polimorfismos APOE e identificar la asociación con variables clínicas y sociales, se ...
Elsa Villarreal, Antonio Bermúdez
doaj +1 more source
Determination of apolipoprotein E genotypes by single-strand conformational polymorphism
Clinical Chemistry, 1993 Abstract We used single-strand conformational polymorphism (SSCP) to determine apolipoprotein E (Apo E) genotypes in 47 individuals. A 295-base-pair (bp) DNA fragment coding for amino acid residues 80-178 of the Apo E protein gave distinct patterns for the three alleles.
M Y, Tsai +6 more
openaire +2 more sources
Improved Method for Genotyping Apolipoprotein E Polymorphisms by a PCR-Based Assay Simultaneously Utilizing Two Distinct Restriction Enzymes [PDF]
Clinical Chemistry, 1997 Apolipoprotein E (apo E) is a protein that plays an essential role in lipid metabolism and distribution (1). The apo E gene is polymorphic, and its three alleles code for isoforms E2, E3, and E4, which differ by single-amino-acid substitutions (2). The apo E3 allele is the predominant isoform in all populations studied.
A, Zivelin +5 more
openaire +2 more sources
PLoS ONE, 2012 Background Apolipoprotein E (APOE) polymorphism is associated with lipid levels. Some studies have reported that blood lipid response to diet or obesity varies depending on APOE genotypes. The aim of this study was to assess the effect of APOE genotypes,
J. Petkevičienė +6 more
semanticscholar +1 more source