Plasma apolipoprotein concentrations and occurrence of cardiovascular events in the general population: an exploratory analysis. [PDF]
Torossian A +12 more
europepmc +1 more source
Proteomics of Prostate Cancer Tissue Small Extracellular Vesicles Reveal Alteration of Metabolism
ABSTRACT Prostate cancer (PCa) is a leading male malignancy worldwide, with metabolic reprogramming being a critical hallmark of its progression. Extracellular vesicles (EVs) derived from tissues directly reflect the tumor microenvironment, offering unique insights into cancer pathophysiology that are unattainable through cell line or biofluid‐derived ...
Lijuan Yu +4 more
wiley +1 more source
Precision medicine requires precision proteomics: discordance between proteomic and clinical assays in UK Biobank. [PDF]
Singh B, Tzoulaki I, Mayr M.
europepmc +1 more source
Proteomic and Lipidomic Profiling of Immune Cell‐Derived Subpopulations of Extracellular Vesicles
ABSTRACT Extracellular vesicles (EVs) are heterogeneous and play important roles in intercellular communication, contributing to physiological and pathological processes. Since few markers currently exist to differentiate subtypes of EVs, this study aimed to determine proteomic and lipidomic differences among four EV subpopulations. Large and small EVs
Anna Lischnig +6 more
wiley +1 more source
Enhanced serum-based seed amplification assay for detecting propagative α-synuclein seeds in Parkinson's disease. [PDF]
Kuang Y +7 more
europepmc +1 more source
ABSTRACT To explore associations of vestibular disorders with all‐cause and cause‐specific dementia and underlying biological mechanisms/neuroimaging changes. A population‐based cohort study of 406,348 UK Biobank participants was conducted. Inverse probability of treatment weighting (IPTW) balanced baseline covariates, and Cox proportional hazards ...
Xiaofei Li +15 more
wiley +1 more source
Reduced Progression of Atherosclerosis in Apolipoprotein E–Deficient Mice Following Consumption of Red Wine, or Its Polyphenols Quercetin or Catechin, Is Associated With Reduced Susceptibility of LDL to Oxidation and Aggregation [PDF]
Tony Hayek +7 more
openalex +1 more source
This study shows that human iPSC‐derived endothelial cells acquire a functional blood–brain barrier phenotype when co‐cultured with brain pericytes and stimulated with CHIR‐99021, a Wnt/β‐catenin activator. This model recapitulates key barrier properties, inflammatory responses, and transcriptomic features of the native human BBB, offering new ...
Henrique Nogueira Pinto +12 more
wiley +1 more source

