Results 51 to 60 of about 61,321 (225)

Entwicklung und funktionelle Charakterisierung rekombinanter Formen der pro-apoptotischen Enzyme Granzym B und Caspase-3 zur gezielten Induktion des programmierten Zelltods in Tumorzellen [PDF]

, 2004
Zytotoxische T-Lymphozyten und natürliche Killer-Zellen sind hochspezialisierte Zellen des Immunsystems, die durch Sekretion der Serin-Protease Granzym B (GrB) und des membranolytischen Proteins Perforin Virusinfizierte, körperfremde oder auch ...
Giesübel, Ulrike
core  

The effect of an HIV-1 viral protease inhibitor on staurosporine-induced apoptosis in immortalized mesangial cells [PDF]

, 2002
CONTEXT: Progressive glomerular sclerosis is a condition characterized by the accumulation of glomerular extracellular matrix and a decrease in the number of glomerular cells.
Camargo, Simone Mafalda Rodrigues, Schor, Nestor, Serone, Adrian Pierce   +2 more
core   +4 more sources

Die Kaltplasma‐Technologie in der Behandlung von Menschen mit chronischen Wunden

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, Volume 24, Issue 2, Page 216-229, February 2026.
Zusammenfassung Chronische Wunden stellen eine erhebliche Belastung sowohl für Patienten als auch für Gesundheitssysteme dar. Die Kaltplasma‐Technologie hat sich bei der Behandlung von Menschen mit chronischen Wunden in den letzten Jahren zunehmend etabliert. Mittlerweile sind verschiedene Kaltplasma‐Geräte verfügbar.
Sander Bekeschus, Lars Boeckmann, Alexander Thiem, Steffen Emmert   +3 more
wiley   +1 more source

Environmental modulators of vascular physiology and inflammation

Experimental Physiology, Volume 111, Issue 2, Page 321-334, 1 February 2026.
Abstract Environmental factors play a crucial role in modulating vascular inflammation, contributing significantly to the development of atherosclerosis and cardiovascular disease. This review synthesizes current evidence on how various environmental exposures influence vascular function and inflammation, with a focus on pollutants such as particulate ...
Anusha N. Seneviratne, Anne Majumdar, Kalpana Surendranath, Mark R. Miller   +3 more
wiley   +1 more source

Calcium and cell death signaling in neurodegeneration and aging

Anais da Academia Brasileira de Ciências, 2009
Transient increase in cytosolic (Cac2+) and mitochondrial Ca2+ (Ca m2+) are essential elements in the control of many physiological processes. However, sustained increases in Ca c2+ and Ca m2+ may contribute to oxidative stress and cell death.
Soraya Smaili, Hanako Hirata, Rodrigo Ureshino, Priscila T. Monteforte, Ana P. Morales, Mari L. Muler, Juliana Terashima, Karen Oseki, Tatiana R. Rosenstock, Guiomar S. Lopes, Claudia Bincoletto   +10 more
doaj   +1 more source

Loss of Tripartite Motif–Containing Protein 21 and UVB‐Induced Systemic Inflammation by Regulating DNA‐Sensing Pathways

Arthritis &Rheumatology, Volume 78, Issue 1, Page 172-183, January 2026.
Objective Patients with systemic lupus erythematosus (SLE) experience photosensitivity, with exposure to UVB light driving lupus flares and triggering symptoms like joint pain, fatigue, and cutaneous lesions. Although the mechanism(s) linking UVB exposure to systemic effects are unclear, type I interferons (IFNs) are known to play a role.
Gantsetseg Tumurkhuu, Graziela Perri, Richard Moore, Lihong Huo, Arati Naveen Kumar, Richard Ainsworth, Trinitee Oliver, Gabriela De Los Santos, David Gibb, Jessica Carriere, Jeong Min Yu, Rachel Abuav, Lindsy Forbess, Daniel J. Wallace, Mariko Ishimori, Wonwoo Shon, Christian Stehlik, Caroline A. Jefferies   +17 more
wiley   +1 more source

Modulatory effects of rutin on biochemical and hematological parameters in hypercholesterolemic Golden Syrian hamsters

Anais da Academia Brasileira de Ciências, 2009
Flavonoids have been reported to exhibit several pharmacological properties, mainly in cardiovascular and inflammatory diseases. In the present study, we observed that rutin, a known glycosylated flavonoid isolated from Dimorphandra mollis, had a ...
Alexandre Kanashiro, Daiani C.O. Andrade, Luciana M. Kabeya, Walter M. Turato, Lucia H. Faccioli, Sérgio A. Uyemura, Yara M. Lucisano-Valim   +6 more
doaj   +1 more source

Advancing Mechano‐Bactericidal Surfaces: Mechanisms, Fabrication, and Synergistic Antimicrobial Strategies

Advanced Materials Interfaces, Volume 12, Issue 23, December 8, 2025.
This review provides a detailed introduction to the fabrication and modulation of nanostructured mechano‐bactericidal surfaces and emphasizes integration of photoactive materials, chemical biocides, stimuli‐responsive self‐cleaning coatings, and electro‐mediated strategies to achieve multifunctional and synergistic antimicrobial effects, providing ...
Yiwen Zhong, Yitong Li, Yang Fu, Zhenfang Zhang, Han Lin, Haiyan Li, Xiao‐Bo Chen, Tianyi Ma, Baohua Jia   +8 more
wiley   +1 more source

India ink induces apoptosis in the yellow clam Mesodesma mactroides (Deshayes, 1854). Optical and ultrastructural study

Anais da Academia Brasileira de Ciências, 2015
This paper reports on the acute inflammatory and cellular process in the yellow clam, Mesodesma mactroides, induced by injection of India ink into the muscular foot.
YURI B.M. CARVALHO, JUAN JETHRO, LUIS H. POERSCH, LUIS A. ROMANO   +3 more
doaj   +1 more source

Identifizierung eines Moleküls, das den Abbau der aktivierten Checkpoint‐Kinase‐1 auslöst und Charakterisierung der nicht‐katalytischen Funktionen von Checkpoint‐Kinase‐1 in Tumorzellen

Angewandte Chemie, Volume 137, Issue 49, December 1, 2025.
In Tumorzellen führt die durch HU induzierte Verlangsamung der DNA‐Replikation zur Aktivierung von CHK1 durch Autophosphorylierung, was einen Zellzyklusarrest bewirkt und die Rekrutierung des DNA‐Reparaturproteins WRN zur Förderung der DNA‐Reparatur und des Zellüberlebens ermöglicht.
Ramy Ashry, Mohamed Abdelsalam, Julia Hausen, Christoph Hieber, Yanira Zeyn, Anne‐Christin Sarnow, Matthias Schmidt, Sara Najafi, Ina Oehme, Matthias Bros, Jia‐Xuan Chen, Mario Dejung, Wolfgang Sippl, Oliver H. Krämer   +13 more
wiley   +1 more source