Results 1 to 10 of about 1,936,005 (364)
Mitochondria and apoptosis. [PDF]
European Journal of Biochemistry, 1998 A variety of key events in apoptosis focus on mitochondria, including the release of caspase activators (such as cytochrome c), changes in electron transport, loss of mitochondrial transmembrane potential, altered cellular oxidation-reduction, and ...
D. Green, John Calvin Reed
semanticscholar +6 more sources
Immunology Today, 1993 Cell death can be accidental or programmed in a multicellular organism. Evidence supports the proposition that there is a 'suicide program' inherent in vertebrate cells which can be activated when the cell's death is desirable for the good of the rest of the community.
YOSHIYUKI KUCHINO
openalex +4 more sources
The Oncologist, 1999 Mechanisms in Hematology is a book with an accompanying interactive CD-ROM designed to assemble basic concepts that underlie clinical understanding and progress. It is presented as a concise text with a series of diagrams that distill diffuse information into a compact form.
Esther D. Israels, Lyonel G. Israels and
openaire +5 more sources
Autophagy in Tumor Immunity and Viral-Based Immunotherapeutic Approaches in Cancer
Cells, 2021 Autophagy is a fundamental catabolic process essential for the maintenance of cellular and tissue homeostasis, as well as directly contributing to the control of invading pathogens.
Ali Zahedi-Amiri +4 more
doaj +1 more source
Molecular Oncology, 2023 A better understanding of multiple myeloma (MM) biology has led to the development of novel therapies. However, MM is still an incurable disease and new pharmacological strategies are needed. Dinaciclib, a multiple cyclin‐dependent kinase (CDK) inhibitor,
Manuel Beltrán‐Visiedo +11 more
doaj +1 more source
Inhibitor of apoptosis proteins and apoptosis [PDF]
Acta Biochimica et Biophysica Sinica, 2008 Apoptosis is a physiological cell death process that plays a critical role in development, homeostasis, and immune defense of multicellular animals. Inhibitor of apoptosis proteins (IAPs) constitute a family of proteins that possess between one and three baculovirus IAP repeats.
Yunbo Wei, Tingjun Fan, Miaomiao Yu
openaire +3 more sources
Regulated IRE1α-dependent decay (RIDD)-mediated reprograming of lipid metabolism in cancer
Nature Communications, 2022 IRE1α cleaves several mRNAs upon accumulation of misfolded proteins. Here the authors show that active IRE1α cleaves DGAT2 mRNA encoding the rate-limiting enzyme in the synthesis of triacylglycerols, suggesting a role of IRE1α in reprogramming lipid ...
Aitor Almanza +13 more
doaj +1 more source
Feeder Cells at the Interface of Natural Killer Cell Activation, Expansion and Gene Editing
Frontiers in Immunology, 2022 Genome engineered natural killer (NK) cell therapies are emerging as a promising cancer immunotherapy platform with potential advantages and remaining uncertainties.
Mark Gurney +5 more
doaj +1 more source
OncoImmunology, 2022 Immunogenic cell death (ICD) has been proposed to be a crucial process for antitumor immunosurveillance. ICD is characterized by the exposure and emission of Damage Associated Molecular Patterns (DAMP), including calreticulin (CRT).
Alfonso Serrano Del Valle +11 more
doaj +1 more source
Metabolism and signaling crosstalk in glioblastoma progression and therapy resistance
Molecular Oncology, EarlyView., 2023 Glioblastoma is one of the most lethal human cancers with no effective treatment nowadays. Here, we review the increasing amount of evidence supporting the connection between cell signaling deregulation and metabolic reprogramming as a key event in glioblastoma resistance to cancer therapy.
Laura Zarzuela +2 more
wiley +1 more source