Results 1 to 10 of about 1,961,106 (365)
Autophagy in Tumor Immunity and Viral-Based Immunotherapeutic Approaches in Cancer
Cells, 2021 Autophagy is a fundamental catabolic process essential for the maintenance of cellular and tissue homeostasis, as well as directly contributing to the control of invading pathogens.
Ali Zahedi-Amiri +4 more
doaj +1 more source
Molecular Oncology, 2023 A better understanding of multiple myeloma (MM) biology has led to the development of novel therapies. However, MM is still an incurable disease and new pharmacological strategies are needed. Dinaciclib, a multiple cyclin‐dependent kinase (CDK) inhibitor,
Manuel Beltrán‐Visiedo +11 more
doaj +1 more source
Regulated IRE1α-dependent decay (RIDD)-mediated reprograming of lipid metabolism in cancer
Nature Communications, 2022 IRE1α cleaves several mRNAs upon accumulation of misfolded proteins. Here the authors show that active IRE1α cleaves DGAT2 mRNA encoding the rate-limiting enzyme in the synthesis of triacylglycerols, suggesting a role of IRE1α in reprogramming lipid ...
Aitor Almanza +13 more
doaj +1 more source
Feeder Cells at the Interface of Natural Killer Cell Activation, Expansion and Gene Editing
Frontiers in Immunology, 2022 Genome engineered natural killer (NK) cell therapies are emerging as a promising cancer immunotherapy platform with potential advantages and remaining uncertainties.
Mark Gurney +5 more
doaj +1 more source
OncoImmunology, 2022 Immunogenic cell death (ICD) has been proposed to be a crucial process for antitumor immunosurveillance. ICD is characterized by the exposure and emission of Damage Associated Molecular Patterns (DAMP), including calreticulin (CRT).
Alfonso Serrano Del Valle +11 more
doaj +1 more source
Necroptosis, pyroptosis and apoptosis: an intricate game of cell death
Cellular & Molecular Immunology, 2021 Cell death is a fundamental physiological process in all living organisms. Its roles extend from embryonic development, organ maintenance, and aging to the coordination of immune responses and autoimmunity.
D. Bertheloot, E. Latz, B. S. Franklin
semanticscholar +1 more source
Apoptosis: A Basic Biological Phenomenon with Wide-ranging Implications in Tissue Kinetics
British Journal of Cancer, 1972 The term apoptosis is proposed for a hitherto little recognized mechanism of controlled cell deletion, which appears to play a complementary but opposite role to mitosis in the regulation of animal cell populations.
John F. R. Kerr +3 more
semanticscholar +1 more source
Apoptosis: A Review of Programmed Cell Death
Toxicologic pathology (Print), 2007 The process of programmed cell death, or apoptosis, is generally characterized by distinct morphological characteristics and energy-dependent biochemical mechanisms.
S. Elmore
semanticscholar +1 more source
Skeletal Muscle, 2019 Background Skeletal muscle atrophy is a pathological condition that contributes to morbidity in a variety of conditions including denervation, cachexia, and aging. Muscle atrophy is characterized as decreased muscle fiber cross-sectional area and protein
Neena Lala-Tabbert +7 more
doaj +1 more source
Combined proteomics and CRISPR‒Cas9 screens in PDX identify ADAM10 as essential for leukemia in vivo
Molecular Cancer, 2023 Background Acute leukemias represent deadly malignancies that require better treatment. As a challenge, treatment is counteracted by a microenvironment protecting dormant leukemia stem cells. Methods To identify responsible surface proteins, we performed
Ehsan Bahrami +20 more
doaj +1 more source