Results 1 to 10 of about 1,314,580 (274)

Autophagy in Tumor Immunity and Viral-Based Immunotherapeutic Approaches in Cancer

open access: yesCells, 2021
Autophagy is a fundamental catabolic process essential for the maintenance of cellular and tissue homeostasis, as well as directly contributing to the control of invading pathogens.
Ali Zahedi-Amiri   +4 more
doaj   +1 more source

Dinaciclib synergizes with BH3 mimetics targeting BCL‐2 and BCL‐XL in multiple myeloma cell lines partially dependent on MCL‐1 and in plasma cells from patients

open access: yesMolecular Oncology, 2023
A better understanding of multiple myeloma (MM) biology has led to the development of novel therapies. However, MM is still an incurable disease and new pharmacological strategies are needed. Dinaciclib, a multiple cyclin‐dependent kinase (CDK) inhibitor,
Manuel Beltrán‐Visiedo   +11 more
doaj   +1 more source

Regulated IRE1α-dependent decay (RIDD)-mediated reprograming of lipid metabolism in cancer

open access: yesNature Communications, 2022
IRE1α cleaves several mRNAs upon accumulation of misfolded proteins. Here the authors show that active IRE1α cleaves DGAT2 mRNA encoding the rate-limiting enzyme in the synthesis of triacylglycerols, suggesting a role of IRE1α in reprogramming lipid ...
Aitor Almanza   +13 more
doaj   +1 more source

Feeder Cells at the Interface of Natural Killer Cell Activation, Expansion and Gene Editing

open access: yesFrontiers in Immunology, 2022
Genome engineered natural killer (NK) cell therapies are emerging as a promising cancer immunotherapy platform with potential advantages and remaining uncertainties.
Mark Gurney   +5 more
doaj   +1 more source

Ecto-calreticulin expression in multiple myeloma correlates with a failed anti-tumoral immune response and bad prognosis

open access: yesOncoImmunology, 2022
Immunogenic cell death (ICD) has been proposed to be a crucial process for antitumor immunosurveillance. ICD is characterized by the exposure and emission of Damage Associated Molecular Patterns (DAMP), including calreticulin (CRT).
Alfonso Serrano Del Valle   +11 more
doaj   +1 more source

Targeted ablation of the cellular inhibitor of apoptosis 1 (cIAP1) attenuates denervation-induced skeletal muscle atrophy

open access: yesSkeletal Muscle, 2019
Background Skeletal muscle atrophy is a pathological condition that contributes to morbidity in a variety of conditions including denervation, cachexia, and aging. Muscle atrophy is characterized as decreased muscle fiber cross-sectional area and protein
Neena Lala-Tabbert   +7 more
doaj   +1 more source

Combined proteomics and CRISPR‒Cas9 screens in PDX identify ADAM10 as essential for leukemia in vivo

open access: yesMolecular Cancer, 2023
Background Acute leukemias represent deadly malignancies that require better treatment. As a challenge, treatment is counteracted by a microenvironment protecting dormant leukemia stem cells. Methods To identify responsible surface proteins, we performed
Ehsan Bahrami   +20 more
doaj   +1 more source

A reporter system for enriching CRISPR/Cas9 knockout cells in technically challenging settings like patient models

open access: yesScientific Reports, 2021
CRISPR/Cas9 represents a valuable tool to determine protein function, but technical hurdles limit its use in challenging settings such as cells unable to grow in vitro like primary leukemia cells and xenografts derived thereof (PDX).
Wen-Hsin Liu   +3 more
doaj   +1 more source

SIRT6 Knockout Cells Resist Apoptosis Initiation but Not Progression: A Computational Method to Evaluate the Progression of Apoptosis [PDF]

open access: yesApoptosis 22 (11), 1336-1343 (2017), 2017
Apoptosis is essential for numerous processes, such as development, resistance to infections, and suppression of tumorigenesis. Here, we investigate the influence of the nutrient sensing and longevity-assuring enzyme SIRT6 on the dynamics of apoptosis triggered by serum starvation. Specifically, we characterize the progression of apoptosis in wild type
arxiv   +1 more source

Smac mimetics synergize with immune checkpoint inhibitors to promote tumour immunity against glioblastoma

open access: yesNature Communications, 2017
Smac mimetics sensitize cancer cells to the extrinsic cell death pathway and stimulate anti-tumour immunity. In this study, the authors show that Smac mimetics can synergize with immune checkpoint inhibitors to control tumour growth in mouse cancer ...
Shawn T. Beug   +16 more
doaj   +1 more source

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