Results 1 to 10 of about 3,080,890 (389)

Autophagy in Tumor Immunity and Viral-Based Immunotherapeutic Approaches in Cancer

Cells, 2021
Autophagy is a fundamental catabolic process essential for the maintenance of cellular and tissue homeostasis, as well as directly contributing to the control of invading pathogens.
Ali Zahedi-Amiri, Kyle Malone, Shawn T. Beug, Tommy Alain, Behzad Yeganeh   +4 more
doaj   +1 more source

Dinaciclib synergizes with BH3 mimetics targeting BCL‐2 and BCL‐XL in multiple myeloma cell lines partially dependent on MCL‐1 and in plasma cells from patients

Molecular Oncology, 2023
A better understanding of multiple myeloma (MM) biology has led to the development of novel therapies. However, MM is still an incurable disease and new pharmacological strategies are needed. Dinaciclib, a multiple cyclin‐dependent kinase (CDK) inhibitor,
Manuel Beltrán‐Visiedo, Nelia Jiménez‐Alduán, Rosana Díez, Marta Cuenca, Andrea Benedi, Alfonso Serrano‐Del Valle, Gemma Azaceta, Luis Palomera, Victor Peperzak, Alberto Anel, Javier Naval, Isabel Marzo   +11 more
doaj   +1 more source

Regulated IRE1α-dependent decay (RIDD)-mediated reprograming of lipid metabolism in cancer

Nature Communications, 2022
IRE1α cleaves several mRNAs upon accumulation of misfolded proteins. Here the authors show that active IRE1α cleaves DGAT2 mRNA encoding the rate-limiting enzyme in the synthesis of triacylglycerols, suggesting a role of IRE1α in reprogramming lipid ...
Aitor Almanza, Katarzyna Mnich, Arnaud Blomme, Claire M. Robinson, Giovanny Rodriguez-Blanco, Sylwia Kierszniowska, Eoghan P. McGrath, Matthieu Le Gallo, Eleftherios Pilalis, Johannes V. Swinnen, Aristotelis Chatziioannou, Eric Chevet, Adrienne M. Gorman, Afshin Samali   +13 more
doaj   +1 more source

Ecto-calreticulin expression in multiple myeloma correlates with a failed anti-tumoral immune response and bad prognosis

OncoImmunology, 2022
Immunogenic cell death (ICD) has been proposed to be a crucial process for antitumor immunosurveillance. ICD is characterized by the exposure and emission of Damage Associated Molecular Patterns (DAMP), including calreticulin (CRT).
Alfonso Serrano Del Valle, Manuel Beltrán-Visiedo, Victoria de Poo-Rodríguez, Nelia Jiménez-Alduán, Gemma Azaceta, Rosana Díez, Beatriz Martínez-Lázaro, Isabel Izquierdo, Luis Palomera, Javier Naval, Alberto Anel, Isabel Marzo   +11 more
doaj   +1 more source

Feeder Cells at the Interface of Natural Killer Cell Activation, Expansion and Gene Editing

Frontiers in Immunology, 2022
Genome engineered natural killer (NK) cell therapies are emerging as a promising cancer immunotherapy platform with potential advantages and remaining uncertainties.
Mark Gurney, Soumyadipta Kundu, Soumyadipta Kundu, Shubham Pandey, Michael O’Dwyer, Michael O’Dwyer   +5 more
doaj   +1 more source

Combined proteomics and CRISPR‒Cas9 screens in PDX identify ADAM10 as essential for leukemia in vivo

Molecular Cancer, 2023
Background Acute leukemias represent deadly malignancies that require better treatment. As a challenge, treatment is counteracted by a microenvironment protecting dormant leukemia stem cells. Methods To identify responsible surface proteins, we performed
Ehsan Bahrami, Jan Philipp Schmid, Vindi Jurinovic, Martin Becker, Anna-Katharina Wirth, Romina Ludwig, Sophie Kreissig, Tania Vanessa Duque Angel, Diana Amend, Katharina Hunt, Rupert Öllinger, Roland Rad, Joris Maximilian Frenz, Maria Solovey, Frank Ziemann, Matthias Mann, Binje Vick, Christian Wichmann, Tobias Herold, Ashok Kumar Jayavelu, Irmela Jeremias   +20 more
doaj   +1 more source

Bim and Bmf synergize to induce apoptosis in Neisseria gonorrhoeae infection [PDF]

, 2009
: Bcl-2 family proteins including the pro-apoptotic BH3-only proteins are central regulators of apoptotic cell death. Here we show by a focused siRNA miniscreen that the synergistic action of the BH3-only proteins Bim and Bmf is required for apoptosis ...
A Cuconati, A Gross, A Muller, A Zychlinsky, AG Letai, B Antonsson, C Dehio, CR Hauck, DR Green, E Oda, EM Kupsch, FJ Bauer, G Kroemer, Guido Kroemer, H Kim, H Puthalakath, H Puthalakath, H. Steven Seifert, HL Howie, IM Mosleh, J Zha, JB Bliska, K Lei, K Nakano, K Rajalingam, K Rajalingam, K Wang, Kathleen Gottschalk, Krishnaraj Rajalingam, L Chen, M Naumann, M Naumann, M Naumann, MA Apicella, MC Wei, N Machuy, N Tajeddine, Nikolaus Machuy, O Billker, O Kepp, Oliver Kepp, P Massari, P Muenzner, P Muenzner, PF Cartron, S Cory, S Makino, SE McCaw, SM Frisch, SN Willis, T Kuwana, T Rudel, T Schmelzle, Thomas Rudel, Volker Brinkmann, Yuri Churin, Z Xia   +56 more
core   +8 more sources

Targeted ablation of the cellular inhibitor of apoptosis 1 (cIAP1) attenuates denervation-induced skeletal muscle atrophy

Skeletal Muscle, 2019
Background Skeletal muscle atrophy is a pathological condition that contributes to morbidity in a variety of conditions including denervation, cachexia, and aging. Muscle atrophy is characterized as decreased muscle fiber cross-sectional area and protein
Neena Lala-Tabbert, Rim Lejmi-Mrad, Kristen Timusk, Marina Fukano, Janelle Holbrook, Martine St-Jean, Eric C. LaCasse, Robert G. Korneluk   +7 more
doaj   +1 more source

A cardinal role for cathepsin D in co-ordinating the host-mediated apoptosis of macrophages and killing of pneumococci [PDF]

, 2011
The bactericidal function of macrophages against pneumococci is enhanced by their apoptotic demise, which is controlled by the anti-apoptotic protein Mcl-1.
Bewley, M.A., Chain, B., Deretic, V., Dockrell, D.H., Francis, S.E., Kroemer, G., Marriott, H.M., Mitchell, T.J., Read, R.C., Tulone, C., Whyte, M.K.B.   +10 more
core   +5 more sources

A reporter system for enriching CRISPR/Cas9 knockout cells in technically challenging settings like patient models

Scientific Reports, 2021
CRISPR/Cas9 represents a valuable tool to determine protein function, but technical hurdles limit its use in challenging settings such as cells unable to grow in vitro like primary leukemia cells and xenografts derived thereof (PDX).
Wen-Hsin Liu, Kerstin Völse, Daniela Senft, Irmela Jeremias   +3 more
doaj   +1 more source