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BioTechniques, 2013 The genetic transformation of target cells is a key tool in modern biological research, as well as in many gene therapy and biotechnology applications. Here we describe a new method for delivery of DNA into several industrially important species of yeast,
Yevhen Filyak +7 more
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Advances in Lung Stem Cells and Lung Cancer Stem Cells
Chinese Journal of Lung Cancer, 2015 Cancer stem cells (CSCs) are emerging as a hot topic for cancer research. Lung CSCs share many characteristics with normal lung stem cells (SCs), including self-renewal and multi-potency for differentiation.
Huijing YIN, Jiong DENG
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Structural Basis of a Novel Agonistic Anti-OX40 Antibody
Biomolecules, 2022 Agonistic antibodies targeting co-stimulating receptor OX40 on T cells are considered as important as (or complementary to) the immune checkpoint blockers in cancer treatment.
Jing Zhang +7 more
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Understanding MAPK Signaling Pathways in Apoptosis
International Journal of Molecular Sciences, 2020 MAPK (mitogen-activated protein kinase) signaling pathways regulate a variety of biological processes through multiple cellular mechanisms. In most of these processes, such as apoptosis, MAPKs have a dual role since they can act as activators or ...
Jicheng Yue, José M. López
semanticscholar +1 more source
SIRT2-mediated deacetylation and deubiquitination of C/EBPβ prevents ethanol-induced liver injury
Cell Discovery, 2021 Protein acetylation has emerged to play pivotal roles in alcoholic liver disease (ALD). Sirutin 2 (SIRT2) is a nicotinamide adenine dinucleotide (NAD+)-dependent deacetylase involved in the regulation of aging, metabolism, and stress.
Yingting Zhang +13 more
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Disruption of epithelial cell-matrix interactions induces apoptosis
Journal of Cell Biology, 1994 Cell-matrix interactions have major effects upon phenotypic features such as gene regulation, cytoskeletal structure, differentiation, and aspects of cell growth control.
S. Frisch, Hunter Francis
semanticscholar +1 more source
Beilstein Journal of Organic Chemistry, 2013 Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder with few therapeutic options. While several gene mutations have been implicated in ALS, the exact cause of neuronal dysfunction is unknown and motor neurons of affected individuals
Allison S. Limpert +2 more
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β-Cell Deficit and Increased β-Cell Apoptosis in Humans With Type 2 Diabetes
Diabetes, 2003 Type 2 diabetes is characterized by impaired insulin secretion. Some but not all studies suggest that a decrease in β-cell mass contributes to this. We examined pancreatic tissue from 124 autopsies: 91 obese cases (BMI >27 kg/m2; 41 with type 2 diabetes,
A. Butler +5 more
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Apoptosis: A Target for Anticancer Therapy
International Journal of Molecular Sciences, 2018 Apoptosis, the cell’s natural mechanism for death, is a promising target for anticancer therapy. Both the intrinsic and extrinsic pathways use caspases to carry out apoptosis through the cleavage of hundreds of proteins.
Claire M Pfeffer, Amareshwar T. K. Singh
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Expression of Bcl-2 Family Member Bid in Normal and Malignant Tissues
Neoplasia: An International Journal for Oncology Research, 2002 Bid is the only known Bcl-2 family member that can function as an agonist of proapoptotic Bcl-2-related proteins such as Bax and Bak. Expression of the proapoptotic Bcl-2 family protein Bid was assessed by immunoblotting and immunohistochemical methods ...
Maryla Krajewska +12 more
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