Results 31 to 40 of about 2,361,281 (339)

Trim17, novel E3 ubiquitin-ligase, initiates neuronal apoptosis [PDF]

, 2010
Accumulating data indicate that the ubiquitin-proteasome system controls apoptosis by regulating the level and the function of key regulatory proteins. In this study, we identified Trim17, a member of the TRIM/RBCC protein family, as one of the critical ...
A Bobba, A Brunet, A Lipkin, A Reymond, AP Aalto, B Pettmann, CM Knudson, CM Pickart, DA Cross, DA Cross, DA Linseman, DP Martin, E Towers, F Jaudon, G Lutfalla, G Meroni, GV Putcha, I Lassot, I Robbins, J Gilley, J Ham, J Ham, J Whitfield, J Yuan, JX Comella, KA Wood, L Swainson, L Vanhille, M Broemer, M Kristiansen, M M Magiera, M Sardiello, MH Glickman, N Canu, R Bhat, R Rahmeh, R Sadoul, RJ Youle, S Desagher, S Desagher, S Mora, S Ogawa, SJ Riedl, SJ Thompson, SR D'Mello, SR Datta, T Urano, TM Miller, TM Miller, V Arce, V Hongisto, Y Du, Z Xia   +52 more
core   +3 more sources

The Proanthocyanidin-Rich Fraction Obtained from Red Rice Germ and Bran Extract Induces HepG2 Hepatocellular Carcinoma Cell Apoptosis

Molecules, 2019
This study aims to determine the anti-carcinogenic effects of the proanthocyanidin-rich fraction (PRFR) obtained from red rice germ and bran extract on HepG2 cells.
Supranee Upanan, Supachai Yodkeeree, Pilaiporn Thippraphan, Wanisa Punfa, Rawiwan Wongpoomchai, Pornngarm Limtrakul (Dejkriengkraikul)   +5 more
doaj   +1 more source

Confocal Raman data analysis enables identifying apoptosis of MCF-7 cells caused by anticancer drug paclitaxel [PDF]

, 2013
Confocal Raman microscopy is a noninvasive, label-free imaging technique used to study apoptosis of live MCF-7 cells. The images are based on Raman spectra of cells components, and their apoptosis is monitored through diffusion of cytochrome c in ...
Attila-Gergely Vegh, Csilla Gergely, Elodie Middendorp, Frederic Cuisinier, Hamideh Salehi, Ivan Panayotov, Pierre-Yves Collart Dutilleul, Sathish Ramakrishnan   +7 more
core   +2 more sources

Inhibition of IRE1 RNase activity modulates the tumor cell secretome and enhances response to chemotherapy

Nature Communications, 2018
IRE1/XBP-1 activation has a major role in Triple negative breast cancer (TNBC). Here, the authors show that inhibition of IRE1’s RNase activity attenuates autocrine and paracrine signaling of pro-tumorigenic cytokines and synergizes with paclitaxel to ...
Susan E. Logue, Eoghan P. McGrath, Patricia Cleary, Stephanie Greene, Katarzyna Mnich, Aitor Almanza, Eric Chevet, Róisín M. Dwyer, Anup Oommen, Patrick Legembre, Florence Godey, Emma C. Madden, Brian Leuzzi, Joanna Obacz, Qingping Zeng, John B. Patterson, Richard Jäger, Adrienne M. Gorman, Afshin Samali   +18 more
doaj   +1 more source

Generation of Tumour-stroma Minispheroids for Drug Efficacy Testing

Bio-Protocol, 2017
The three-dimensional organisation of cells in a tissue and their interaction with adjacent cells and extracellular matrix is a key determinant of cellular responses, including how tumour cells respond to stress conditions or therapeutic drugs (Elliott ...
Mark Watters , Eva Szegezdi
doaj   +1 more source

Mitochondrial permeabilization engages NF-κB-dependent anti-tumour activity under caspase deficiency [PDF]

, 2017
Apoptosis represents a key anti-cancer therapeutic effector mechanism. During apoptosis, mitochondrial outer membrane permeabilization (MOMP) typically kills cells even in the absence of caspase activity.
Albert, Matthew L., Blyth, Karen, Bock, Florian, Cao, Kai, Cloix, Catherine, Dhayade, Sandeep, Fort, Loic, Giampazolias, Evangelos, Ichim, Gabriel, Lecis, Daniele, Lopez, Jonathan, Machesky, Laura, Milling, Simon, Oberst, Andrew, Orozco, Susana, Peltzer, Nieves, Proïcs, Emma, Ricci, Jean-Ehrland, Roca, Alba, Rubio-Patiño, Camila, Ryan, Kevin M., Tait, Stephen W.G., Taraborrelli, Lucia, Walczak, Henning, Woodham, Emma, Yatim, Nader, Zunino, Barbara   +26 more
core   +2 more sources

Photoablation at single cell resolution and its application in the Drosophila epidermis and peripheral nervous system

Frontiers in Physiology, 2023
Tissues contain diverse cell populations that, together, make up physiologically functional units. A remarkable example is the animal epidermis, where neuronal and non-neuronal cells intermingle to allow somatosensory perception.
Federica Mangione, Rocco D’Antuono, Nicolas Tapon   +2 more
doaj   +1 more source

Mitochondria and apoptosis [PDF]

European Journal of Biochemistry, 1998
Programmed cell death serves as a major mechanism for the precise regulation of cell numbers and as a defense mechanism to remove unwanted and potentially dangerous cells. Despite the striking heterogeneity of cell death induction pathways, the execution of the death program is often associated with characteristic morphological and biochemical changes,
Mignotte, Bernard, Vayssière, Jean-Luc
openaire   +4 more sources

Saturated free fatty acids and apoptosis in microvascular mesangial cells: palmitate activates pro-apoptotic signaling involving caspase 9 and mitochondrial release of endonuclease G [PDF]

, 2005
BACKGROUND: In type 2 diabetes, free fatty acids (FFA) accumulate in microvascular cells, but the phenotypic consequences of FFA accumulation in the microvasculature are incompletely understood. Here we investigated whether saturated FFA induce apoptosis
Mishra, Rangnath, Simonson, Michael S
core   +3 more sources

Apoptosis

Bitlis Eren Üniversitesi Fen Bilimleri Dergisi, 2014
Apoptozis ya da programlı hücre ölümü sağlıklı çok hücreli organizmada meydana gelen fizyolojik bir olgudur. Bu olgu, temel tıp bilimlerinde anlaşılması güç birçok olayın açıklanmasında kullanılmıştır. Hücre ölümüne sebep olan temel faktörlerden birinin serbest radikaller olduğu bilinmektedir.
MİS, Leyla, YELTEKİN, Aslı Çilingir
openaire   +3 more sources