Results 251 to 260 of about 611,822 (296)

Unmixing Apoptotic Signals

Science, 2003
The Bax and Bak proteins have been said to provide a "mitochondrial gateway" to apoptosis or cell death, because stimuli that cause death through effects on mitochondria require the action of one or the other of these proteins at the outer mitochondrial membrane. Scorrano et al.
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MDR1 Up-Regulated by Apoptotic Stimuli Suppresses Apoptotic Signaling

Pharmaceutical Research, 2002
Recently, MDR1 (P-glycoprotein) and related transporters have been suggested to play a fundamental role in regulating apoptosis, but little information is available concerning the role of MDR1. Here, the effect of apoptotic stimuli on the MDR1 mRNA and apoptotic signaling was examined in MDR1-overexpressing cells.The expression levels of mRNA for MDR1,
Toshiyuki, Sakaeda, Tsutomu, Nakamura, Midori, Hirai, Takashi, Kimura, Atsushi, Wada, Tatsurou, Yagami, Hironao, Kobayashi, Shunji, Nagata, Noboru, Okamura, Takayoshi, Yoshikawa, Toshiro, Shirakawa, Akinobu, Gotoh, Masafumi, Matsuo, Katsuhiko, Okumura   +13 more
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Apoptotic, non-apoptotic, and anti-apoptotic pathways of tumor necrosis factor signalling

Biochemical Pharmacology, 1998
Early events in the signalling of tumor necrosis factor-receptor 1 (TNF-R1), which is the main TNF receptor on most cell types, have been clarified recently. A multimolecular signal transducing complex from which several pathways originate rapidly forms upon TNF-induced aggregation of the receptor.
Gioacchino Natoli, Antonio Costanzo, Francesco Guido, Francesca Moretti, LEVRERO, Massimo   +4 more
openaire   +3 more sources

Apoptotic and anti-apoptotic signals in acute leukemias

Journal of Clinical Oncology, 2004
6712 Background: Programmed cell death is an important factor in malignant disorders for two reasons: 1-Suppression of apoptosis is critical in cancer both in initiation and progression phases.
Paydas, S, Tanriverdi, K, Disel, U, Yavuz, S, Sahin, B, Baslamisli, F   +5 more
openaire   +2 more sources

Tacrolimus-Induced Apoptotic Signal Transduction Pathway

Transplantation Proceedings, 2008
Tacrolimus (FK506) has been widely used as an immunosuppressant. We examined the effects of FK506 on expression of apoptotic signal transduction pathway proteins of Jurkat human T lymphocytes. We investigated the effects of FK506 on apoptosis, cell viability, caspase family protein activity, Western blotts of Bcl-2, Bak, Fas, Fas-L, CDK4, and cyclin D1,
S J N, Choi, H S, You, S Y, Chung
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Apoptotic signaling in salivary mucoepidermoid carcinoma

Head & Neck, 2019
AbstractBackgroundMucoepidermoid carcinoma is the most common malignant tumor of salivary glands. Apoptosis plays an important role in organogenesis of glandular structures, and aberrations of apoptotic mechanisms is associated with a wide array of pathologic conditions.MethodsThe immunoexpression of proteins associated with apoptosis and proliferation
Gabriela M. da Silva, Victoria Saavedra, Renata C. F. Ianez, Elen A. de Sousa, Ágatha N. Gomes, Natalie Kelner, Maria A. Nagai, Luiz P. Kowalski, Fernando A. Soares, Silvia V. Lourenço, Cláudia M. Coutinho‐Camillo   +10 more
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GnRH receptor and apoptotic signaling

2000
In addition to its hypophysiotropic action, gonadotropin-releasing hormone (GnRH) can modify activity in extrapituitary organs and peripheral tumors. GnRH analogs are the preferred treatment for advanced and even metastatic or recurring carcinomas in vivo and in vitro.
A, Imai, T, Tamaya
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Pro‐Apoptotic and Anti‐Apoptotic Molecules Affecting Pathways of Signal Transduction

Annals of the New York Academy of Sciences, 2003
Abstract: Selective inhibition of the “false” proliferative signals via targeting tyrosine kinases resulting in the induction of apoptosis by depletion of the “survival factors” is one of the most studied and widely accepted concepts of modern chemotherapy.
G, Kéri, G, Racz, K, Magyar, L, Orfi, A, Horváth, R, Schwab, B B, Hegymegi, B, Szende   +7 more
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Apoptotic Signals at the Golgi

Science's STKE, 2000
Caspases are the proteases that transduce proapoptotic signals in cells. Mancini et al. show that caspase-2 localizes primarily to the cytoplasmic face of the Golgi complex. Casapse-2 cleaved golgin-160, a Golgi membrane protein implicated in maintaining Golgi integrity and membrane trafficking.
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Apoptotic signaling: Beyond cell death

Seminars in Cell & Developmental Biology
Apoptosis is the best described form of regulated cell death, and was, until relatively recently, considered irreversible once particular biochemical points-of-no-return were activated. In this manuscript, we examine the mechanisms cells use to escape from a self-amplifying death signaling module. We discuss the role of feedback, dynamics, propagation,
Maddalena Nano, Denise J. Montell
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