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Apoptotic signal transduction: emerging pathways
Biochemistry and Cell Biology, 1998Apoptosis is a counterbalance to mechanisms of cell proliferation and is critically important in regulation of the immune system, development, and normal tissue homeostasis. Mammalian signal transduction pathways affecting apoptosis are more complex than their counterparts in the nematode Caenorhabditis elegans, a valuable model system that has ...
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Apoptotic signal transduction pathways in diabetes
Biochemical Pharmacology, 2003Failure of insulin producing pancreatic beta-cells is a common characteristic of type 1 (insulin-dependent) and type 2 (insulin non-dependent) diabetes mellitus. Accumulating evidence suggests that programmed cell death (apoptosis) is the main form of beta-cell death in these disorders.
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Tissue specificity of apoptotic signal transduction
Medical Electron Microscopy, 2004Two major apoptotic pathways exist in mammalian cells: the death receptor and mitochondrial pathways. The cross talk between these two pathways is minimal, and they operate basically independent of each other under physiological conditions. Therefore, the tissue specificity of the signal pathway during apoptosis is observed in various tissues and ...
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Ceramide in Apoptotic Signaling and Anticancer Therapy
Current Medicinal Chemistry, 2006Ceramide, a product of sphingolipid metabolism, is generated in response to various stress stimuli, such as tumor necrosis factor-alpha, CD95/Fas, chemotherapeutic agents, and irradiation. Ceramide may modulate the biochemical and cellular processes that lead to apoptosis.
C F, Lin, C L, Chen, Y S, Lin
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Intercellular transfer of apoptotic signals via electrofusion
Experimental Cell Research, 2012We determined whether cells that are induced to undergo anoikis by matrix detachment can initiate apoptosis in healthy cells following electroporation-induced fusion. Separate populations of MDCK cells undergoing anoikis and stained with FITC-annexin or viable MDCK cells that were labeled with spectrally discrete fluorescent beads were electroporated ...
Jin Suk, Park +2 more
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Apoptotic Signaling in Multiple Myeloma: Therapeutic Implications
International Journal of Hematology, 2003Fifteen thousand new cases of multiple myeloma (MM) will occur in the United States in 2003, and the disease remains incurable. Diverse classes of chemotherapeutic agents induce cell death or apoptosis in MM cells; however, prolonged drug exposures ultimately induce chemoresistance.
Dharminder, Chauhan +2 more
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Apoptotic signaling induces hyperpermeability following hemorrhagic shock
American Journal of Physiology-Heart and Circulatory Physiology, 2007Hemorrhagic shock (HS) disrupts the endothelial cell barrier, resulting in microvascular hyperpermeability. Recent studies have also demonstrated that activation of the apoptotic signaling cascade is involved in endothelial dysfunction, which may result in hyperpermeability.
Ed W, Childs +4 more
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An Apoptotic ‘Eat Me’ Signal: Phosphatidylserine Exposure
Trends in Cell Biology, 2015Apoptosis and the clearance of apoptotic cells are essential processes in animal development and homeostasis. For apoptotic cells to be cleared, they must display an 'eat me' signal, most likely phosphatidylserine (PtdSer) exposure, which prompts phagocytes to engulf the cells.
Katsumori, Segawa, Shigekazu, Nagata
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Apoptotic Signaling Pathways in Cancer
2023Apoptosis, called programmed cell death, is one of the most important cellular mechanisms regulating the elimination of harmful and unnecessary cells. This tightly regulated suicide program is very important in the development and maintenance of tissue homeostasis. Disruption of apoptosis, also called natural defense mechanism, causes abnormal cellular
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Surface code—biophysical signals for apoptotic cell clearance
Physical Biology, 2013Apoptotic cell death and the clearance of dying cells play an important and physiological role in embryonic development and normal tissue turnover. In contrast to necrosis, apoptosis proceeds in an anti-inflammatory manner. It is orchestrated by the timed release and/or exposure of so-called 'find-me', 'eat me' and 'tolerate me' signals.
Biermann +7 more
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