Results 271 to 280 of about 611,822 (296)

The modular nature of apoptotic signaling proteins

Cellular and Molecular Life Sciences CMLS, 1999
Apoptosis, initiated by a variety of stimuli, is a physiological process that engages a well-ordered signaling cascade, eventually leading to the controlled death of the cell. The most extensively studied apoptotic stimulus is the binding of death receptors related to CD95 (Fas/Apo1) by their respective ligands.
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[Sphingolipid-mediated apoptotic signaling pathways].

Journal de la Societe de biologie, 2004
Various sphingolipids are being viewed as bioactive molecules and/or second messengers. Among them, ceramide (or N-acylsphingosine) and sphingosine generally behave as pro-apoptotic mediators. Indeed, ceramide mediates the death signal initiated by numerous stress agents which either stimulate its de novo synthesis or activate sphingomyelinases that ...
Olivier, Cuvillier, Nathalie, Andrieu-Abadie, Bruno, Ségui, Sophie, Malagarie-Cazenave, Claudine, Tardy, Elisabeth, Bonhoure, Thierry, Levade   +6 more
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Upregulating Apoptotic Signaling in Neurofibromatosis

2009
Abstract : The NF1 that is highly expressed in developing neural cells and loss-of-function mutations in NF1 gene results in deregulation of Ras signaling which contributes to cancer development. We reported that hyperactive Ras could induce apoptosis after inhibiting PKC which was not harmful to normal, cells.
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Calcium signaling in apoptotic mammalian cells

2014
The calcium ion (Ca2+), as an important second messenger, is known to be involved in many cellular functions. The present study is aimed at investigating the roles of Ca2+ signaling in regulating apoptosis of mammalian cells. We tried to answer the following questions: (1) Is the mitochondrial Ca2+ signal involved in the early stage to drive the ...
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Non-apoptotic activation of Drosophila caspase-2/9 modulates JNK signaling, the tumor microenvironment, and growth of wound-like tumors

Cell Reports, 2022
Derek Cui Xu, Kenneth M Yamada, Luis Alberto Baena-López   +2 more
exaly  

The therapeutic potential of targeting regulated non-apoptotic cell death

Nature Reviews Drug Discovery, 2023
Kamyar Hadian, Brent R Stockwell
exaly  

Control of signaling-mediated clearance of apoptotic cells by the tumor suppressor p53

Science, 2015
Sanguine Byun, Astrid Weins, Samy Hakroush   +2 more
exaly  

Sequential Application of Anticancer Drugs Enhances Cell Death by Rewiring Apoptotic Signaling Networks

Cell, 2012
Michael J Lee, Anne Margriet Heijink, Peter K Sorger   +2 more
exaly  

Solution Structure of BID, an Intracellular Amplifier of Apoptotic Signaling

Cell, 1999
James J Chou, Guy S Salvesen, Junying Yuan   +2 more
exaly  

Beginnings of a Good Apoptotic Meal: The Find-Me and Eat-Me Signaling Pathways

Immunity, 2011
Kodi S Ravichandran
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