Results 71 to 80 of about 68,358 (287)
Aptamers as therapeutics [PDF]
Nature Reviews Drug Discovery, 2010 Nucleic acid aptamers can be selected from pools of random-sequence oligonucleotides to bind a wide range of biomedically relevant proteins with affinities and specificities that are comparable to antibodies. Aptamers exhibit significant advantages relative to protein therapeutics in terms of size, synthetic accessibility and modification by medicinal ...
Keefe, Anthony D. +2 more
openaire +2 more sources
Detection and beyond: challenges and advances in aptamer-based biosensors
Materials Advances, 2020 This review provides insight into how current problems of biosensors can be solved by the use of nucleic acid aptamers.
H. Yoo, Hyesung Jo, Seung Soo Oh
semanticscholar +1 more source
Assembling a True “Olympic Gel” From over 16 000 Combinatorial DNA Rings
Advanced Materials, EarlyView.Olympic gels are an elusive class of soft matter, consisting of molecular networks held together purely by mechanically interlocked rings. Their topological structure promises unique properties and functions, but their synthesis has proven notoriously difficult.
Sarah K. Speed +9 more
wiley +1 more source
Advanced Materials Interfaces, EarlyView.ABSTRACT Capturing proteins is easy since their amphiphilic nature allows them to bind to almost any surface. Because of this, releasing them is challenging since various interactions need to be considered for this. We present a simple method to reversibly adsorb proteins on stabilized electrodes.
Erik J. Postma +3 more
wiley +1 more source
Aptamer-Functionalized Nanoparticles in Targeted Delivery and Cancer Therapy
International Journal of Molecular Sciences, 2020 Using nanoparticles to carry and delivery anticancer drugs holds much promise in cancer therapy, but nanoparticles per se are lacking specificity. Active targeting, that is, using specific ligands to functionalize nanoparticles, is attracting much ...
Z. Fu, J. Xiang
semanticscholar +1 more source
Advanced Materials Technologies, EarlyView.This review explores advances in wearable and lab‐on‐chip technologies for breast cancer detection. Covering tactile, thermal, ultrasound, microwave, electrical impedance tomography, electrochemical, microelectromechanical, and optical systems, it highlights innovations in flexible electronics, nanomaterials, and machine learning.
Neshika Wijewardhane +4 more
wiley +1 more source
Molecular Therapy: Nucleic Acids, 2015 Hepatitis C virus (HCV) is the major cause of progressive liver disease such as chronic hepatitis, cirrhosis, and hepatocellular carcinoma. Previously, we reported that a 29 nucleotide-long 2’-F pyrimidine modified RNA aptamer against the HCV ...
Chang Ho Lee +5 more
doaj +1 more source
Probing high affinity sequences of DNA aptamer against VEGF165. [PDF]
PLoS ONE, 2012 Vascular endothelial growth factor (VEGF(165)) is a potent angiogenic mitogen commonly overexpressed in cancerous cells. It contains two main binding domains, the receptor-binding domain (RBD) and the heparin-binding domain (HBD). This study attempted to
Harleen Kaur, Lin-Yue Lanry Yung
doaj +1 more source
Advanced Materials Technologies, EarlyView.Transducers convert physical signals into electrical and optical representations, yet each mechanism is bounded by intrinsic trade‐offs across bandwidth, sensitivity, speed, and energy. This review maps transduction mechanisms across physical scale and frequency, showing how heterogeneous integration and multiphysics co‐design transform isolated ...
Aolei Xu +8 more
wiley +1 more source
Nature CommunicationsMultiple receptor analysis-based DNA molecular computation has been developed to mitigate the off-target effect caused by nonspecific expression of cell membrane receptors.
Decui Tang +9 more
doaj +1 more source