Results 131 to 140 of about 2,316 (158)
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International Journal of Biological Macromolecules, 2018
AS1411 is a nucleolin-binding aptamer which attracted great interest as active targeting ligand for the selective delivery of therapeutic agents to tumour cells. In this work we selected three AS1411 derivatives 5'-conjugated with lipophilic tails and studied their properties in view of their application in liposomial formulations and/or lipid coated ...
Riccardi Claudia +6 more
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AS1411 is a nucleolin-binding aptamer which attracted great interest as active targeting ligand for the selective delivery of therapeutic agents to tumour cells. In this work we selected three AS1411 derivatives 5'-conjugated with lipophilic tails and studied their properties in view of their application in liposomial formulations and/or lipid coated ...
Riccardi Claudia +6 more
openaire +5 more sources
AS1411 aptamer for targetable photosensitizer delivery
2009 International Conference on Biomedical and Pharmaceutical Engineering, 2009A specialized G-quadruplex DNA aptamer with nucleolin targeting ability, AS1411, has been studied for cancer therapy. In this study, we report a novel delivery strategy for chemo-photodynamic combined treatment using AS1411 aptamer conjugated with tetra-(N-methyl-4-pyridyl)-porphine by intercalation and outside binding.
M. J. Shieh, Y. A. Shieh, P. S. Lai
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AS1411 aptamer based nanomaterials: A novel approach for breast cancer therapy
International Journal of Biological MacromoleculesBreast cancer remains a leading cause of cancer-related mortality in women, accounting for 23.8 % of all female cancer cases. Existing therapies often lack tumor specificity, leading to severe off-target toxicity, dose-limiting side effects, and poor patient compliance. These limitations underscore the urgent need for innovative strategies that enhance
Tenzin Tsering Dongsar +2 more
exaly +3 more sources
Physical Chemistry Chemical Physics, 2022
The interfacial behaviors of conjugated AS1411 molecules at lipid bilayer interfaces were investigated by SFG-VS. The AS1411 molecules at the DMTAP bilayer show a higher binding affinity but a slower binding kinetics compared to the DMDAP bilayer.
Penghua Li +10 more
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The interfacial behaviors of conjugated AS1411 molecules at lipid bilayer interfaces were investigated by SFG-VS. The AS1411 molecules at the DMTAP bilayer show a higher binding affinity but a slower binding kinetics compared to the DMDAP bilayer.
Penghua Li +10 more
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STUDY OF CATIONIC PORPHYRIN COMPLEXES WITH APTAMER AS1411 BY EPR AND OPTICAL SPECTROSCOPY
X Международная конференция молодых ученых: биоинформатиков, биотехнологов, биофизиков, вирусологов и молекулярных биологов — 2023: Cб. тез., 2023Porphyrins are photosensitizers (PS) for photodynamic therapy (PDT). However, the most effective PS have poor water solubility, which limits their application in PDT. The solution to this problem is the use of targeted drug delivery, such as the oligonucleotide AS1411.
T.A. Khlynova +2 more
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Targeted delivery of melittin to cancer cells by AS1411 anti-nucleolin aptamer
Drug Development and Industrial Pharmacy, 2018Melittin, a small water-soluble cationic amphipathic α-helical linear peptide, consisted of 26 amino acids, is the honeybee venom major constituent. Several reports have proved the lytic and apoptotic effects of melittin in several cancerous cell lines.
Seyed Hossein, Rajabnejad +5 more
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Journal of Nanoscience and Nanotechnology, 2020
AS1411 Aptamer-functionalized liposome was successfully formulated and found to be nanosized. Flow cytometer and CLSM results demonstrated that Aptamer enhanced the targeting of carrier in the cancer cells via nucleolin-mediated transmembrane endocytosis pathway.
Lanyu, Jiang, Hui, Wang, Shaozheng, Chen
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AS1411 Aptamer-functionalized liposome was successfully formulated and found to be nanosized. Flow cytometer and CLSM results demonstrated that Aptamer enhanced the targeting of carrier in the cancer cells via nucleolin-mediated transmembrane endocytosis pathway.
Lanyu, Jiang, Hui, Wang, Shaozheng, Chen
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AS1411 aptamer in melanoma therapy: Harnessing targeted strategies for precision treatment
Pathology - Research and PracticeMelanoma, the fifth most prevalent cancer type in both men and women, is characterized by substantial incidence and mortality rates. Melanoma treatment varies by stage and may include surgery, chemotherapy, immunotherapy, and targeted therapies. The AS1411 aptamer, which targets the overexpressed nucleolin protein in melanoma cells, has emerged as a ...
Monireh Askarzadeh +4 more
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In silico activity of AS1411 aptamer against nucleolin of cancer cells
2021The support of this work by the research council of Isfahan University of Medical Sciences under grant number 298096 and ethics code IR.MUI.RESEARCH.
Farahbakhsh, Z. +4 more
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Biomaterials, 2014
BRAF gene mutation is found in more than 60% of malignant melanomas, which are difficult to treat. In this study, a new tumor-targeting liposome was developed to deliver anti-BRAF siRNA (siBraf) for the treatment of melanomas. Nucleolin is overexpressed on the surface of cancer cells.
Liyu, Li +6 more
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BRAF gene mutation is found in more than 60% of malignant melanomas, which are difficult to treat. In this study, a new tumor-targeting liposome was developed to deliver anti-BRAF siRNA (siBraf) for the treatment of melanomas. Nucleolin is overexpressed on the surface of cancer cells.
Liyu, Li +6 more
openaire +2 more sources