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Characterizing Oligonucleotide Uptake in Cultured Cells: A Case Study Using AS1411 Aptamer
2019Oligonucleotides can be designed or evolved to bind to specific DNA, RNA, protein, or small molecule targets and thereby alter the biological function of the target. The therapeutic potential of oligonucleotides targeted to intracellular molecules will depend largely on their ability to be taken up by the cells of interest, as well as their subsequent ...
Elsa M, Reyes-Reyes, Paula J, Bates
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Tumor targeting with a99mTc-labeled AS1411 aptamer in prostate tumor cells
Journal of Drug Targeting, 2015AS1411, a 26-base guanine-rich oligonucleotide aptamer, has high affinity to nucleolin, mainly on tumor cell surfaces. In this study, a modified AS1411 was labeled with (99m)Tc and evaluated as a potential tumor-targeting agent for imaging. The AS1411 aptamer was conjugated with HYNIC and labeled with (99m)Tc in the presence a co-ligand.
Zohreh, Noaparast +3 more
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AS1411, a Novel DNA Aptamer as a Potential Treatment of Acute Myelogenous Leukaemia (AML).
Blood, 2006Abstract AS1411 (formerly AGRO100) is the first nucleic acid aptamer to enter oncology trials and is currently in a Phase I study in renal and lung patients. AS1411 is a 26mer unmodified phosphodiester-based guanosine rich oligonucleotide which, as a dimer, forms a serum-resistant quartet structure.
Kirti Shah +4 more
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AS1411 aptamer tagged PLGA‐lecithin‐PEG nanoparticles for tumor cell targeting and drug delivery
Biotechnology and Bioengineering, 2012AbstractLiposomes and polymers are widely used drug carriers for controlled release since they offer many advantages like increased treatment effectiveness, reduced toxicity and are of biodegradable nature. In this work, anticancer drug‐loaded PLGA‐lecithin‐PEG nanoparticles (NPs) were synthesized and were functionalized with AS1411 anti‐nucleolin ...
Athulya, Aravind +7 more
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Journal of Colloid and Interface Science, 2017
Chemotherapy is still the main adjuvant strategy after surgery in glioblastoma therapy. As the main obstacles of chemotherapeutic drugs for glioblastoma treatment, the blood brain barrier (BBB) and non-specific delivery to non-tumor tissues greatly limit the accumulation of drugs into tumor tissues and simultaneously cause serious toxicity to nearby ...
Zimiao, Luo +9 more
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Chemotherapy is still the main adjuvant strategy after surgery in glioblastoma therapy. As the main obstacles of chemotherapeutic drugs for glioblastoma treatment, the blood brain barrier (BBB) and non-specific delivery to non-tumor tissues greatly limit the accumulation of drugs into tumor tissues and simultaneously cause serious toxicity to nearby ...
Zimiao, Luo +9 more
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Anti-nucleolin aptamer-guided anticancer activity of AS1411-Chalcone conjugate in breast cancer
Biochemical and Biophysical Research CommunicationsThe DNA aptamer AS1411 is a 26-nucleotide, guanine-rich oligonucleotide with high specificity for nucleolin-a multifunctional protein overexpressed on the surface of many cancer cells and involved in key processes such as proliferation and apoptosis. By selectively binding nucleolin, AS1411 serves as an ideal targeting ligand for delivering therapeutic
Vijay Murali Ravi Mythili +8 more
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AS1411: Development of an Anticancer Aptamer
2008Nigel Courtenay-Luck, Donald M. Miller
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Interaction study of Dox-incorporated AS1411 aptamer and nucleolin by molecular dynamics simulation
Molecular Simulation, 2023Pichayanoot Rotkrua +2 more
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