Results 21 to 30 of about 2,316 (158)
A Synthetic Aptamer-Drug Adduct for Targeted Liver Cancer Therapy. [PDF]
PLoS ONE, 2015 AS1411 (previously known as AGRO100) is a 26 nucleotide guanine-rich DNA aptamer which forms a guanine quadruplex structure. AS1411 has shown promising utility as a treatment for cancers in Phase I and Phase II clinical trials without causing major side ...
Thu Le Trinh +7 more
doaj +1 more source
Molecules, 2022 Hypoxia-activated prodrugs (HAPs) with selective toxicity in tumor hypoxic microenvironments are a new strategy for tumor treatment with fewer side effects.
Xuan Wang, Qing Chen, Congxiao Lu
doaj +1 more source
Computable structured aptamer for targeted treatment of ovarian cancer
Frontiers in Genetics, 2023 Nucleolin protein expression is higher on the ovarian cancer cell surface. AS1411, a DNA aptamer, can bind with nucleolin protein specifically. In this study, we developed HA and ST DNA tiles to assemble six AS1411 aptamers to deliver doxorubicin.
Luoshan Ruan +8 more
doaj +1 more source
Intracellular Monitoring of AS1411 Aptamer by Time-Resolved Microspectrofluorimetry and Fluorescence Imaging [PDF]
Journal of Fluorescence, 2015 Time-resolved microspectrofluorimetry and fluorescence microscopy imaging-two complementary fluorescence techniques-provide important information about the intracellular distribution, level of uptake and binding/interactions inside living cell of the labeled molecule of interest.
Bok, Jiří +4 more
openaire +3 more sources
Pharmaceutics, 2021 Topical liposomal drug formulations containing AS1411-aptamer conjugated liposomes were designed to deliver in a sustained way the 5-fluorouracil to the tumor site but also to increase the compliance of patients with basal cell carcinoma.
Anca N. Cadinoiu +5 more
doaj +1 more source
Journal of Nanobiotechnology, 2023 Hepatocellular carcinoma (HCC) is a leading cause of death globally. Even though the progressive invention of some very potent therapeutics has been seen, the success is limited due to the chemotherapeutic resistance and recurrence in HCC.
Moumita Dhara +6 more
doaj +1 more source
Development and Evaluation of AT11-Guided Liposomes for Human Papillomavirus Cancer
Medical Sciences Forum, 2022 Conventional anticancer therapies present low specificity, leading to several secondary effects. To improve these drawbacks, aptamers able to fold into G-quadruplex (G4) are being used to promote drug accumulation in cancer cells.
Jéssica Lopes-Nunes +2 more
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Carbon Dots-AS1411 Aptamer Nanoconjugate for Ultrasensitive Spectrofluorometric Detection of Cancer Cells [PDF]
Scientific Reports, 2017 AbstractIn the present study, a sensitive and selective signal-on method for aptamer based spectrofluorometric detection of cancer cells is introduced. AS1411, a nucleolin aptamer, is wrapped around water-soluble carbon dots and used as a probe for the detection of several types of cancer cells.
Hasan Motaghi +2 more
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AS1411-functionalized delivery nanosystems for targeted cancer therapy
Exploration of Medicine, 2021 Nucleolin (NCL) is a multifunctional nucleolar phosphoprotein harboring critical roles in cells such as cell proliferation, survival, and growth. The dysregulation and overexpression of NCL are related to various pathologic and oncological indications ...
Pooria Safarzadeh Kozani +2 more
doaj +1 more source
Biomedicine & Pharmacotherapy, 2022 Severe side effects of chemotherapy agents on vital organs are the major causes of cancer-related mortality, not merely cancer disease. Encapsulating chemotherapeutic molecules in nanocarriers is a justifiable solution in decreasing the risk of their side effects and boosting the efficiency of treatment. The present study has developed the doxorubicin (
Nashmin Fayazi, Hosseini +5 more
openaire +2 more sources