Anti-nucleolin aptamer AS1411: an advancing therapeutic [PDF]
Frontiers in Molecular Biosciences, 2023 Targeted therapy is highly desirable, as it allows for selective cytotoxicity on diseased cells without off-target side effects. Nucleolin is a remarkable target for cancer therapy given its high abundance, selective presence on the plasma membrane, and ...
Neelam Sharma-Walia
exaly +6 more sources
Insights into the binding mode of AS1411 aptamer to nucleolin
Frontiers in Molecular Biosciences, 2022 AS1411 aptamer can function as a recognition probe to detect the cell surface nucleolin overexpressed in cancer cells, however, little is known about their binding process.
Lianjun Zhang, Fuze Jiang
exaly +6 more sources
Locking up the AS1411 Aptamer with a Flanking Duplex: Towards an Improved Nucleolin-Targeting [PDF]
Pharmaceuticals, 2021 We have designed AS1411-N6, a derivative of the nucleolin (NCL)-binding aptamer AS1411, by adding six nucleotides to the 5′-end that are complementary to nucleotides at the 3′-end forcing it into a stem-loop structure. We evaluated by several biophysical
Carla Cruz +2 more
exaly +5 more sources
Nucleolin Overexpression Confers Increased Sensitivity to the Anti-Nucleolin Aptamer, AS1411 [PDF]
Cancer Investigation, 2018 AS1411 is an antiproliferative DNA aptamer, which binds the ubiquitous protein, nucleolin. In this study, we show that constitutive overexpression of nucleolin confers increased sensitivity to the growth inhibitory effects of AS1411. HeLa cells overexpressing nucleolin have an increased growth rate and invasiveness relative to control cells.
Shelia Thomas +2 more
exaly +5 more sources
Mechanistic studies of anticancer aptamer AS1411 reveal a novel role for nucleolin in regulating Rac1 activation [PDF]
Molecular Oncology, 2015 AS1411 is a G‐rich quadruplex‐forming oligodeoxynucleotide that binds specifically to nucleolin, a protein found on the surface and in the cytoplasm of most malignant cells but absent from the surface/cytoplasm of most normal cells. AS1411 has shown promising clinical activity and is being widely used as a tumor‐targeting agent, but its mechanism of ...
Matthew Forsthoefel
exaly +6 more sources
Radiosensitization of breast cancer cells using AS1411 aptamer-conjugated gold nanoparticles [PDF]
Radiation Oncology, 2021 Background Gold nanoparticles (GNPs) have been used to sensitize cancer cells and enhance the absorbed dose delivered to such cells. Active targeting can provide specific effect and higher uptake of the GNPs in the tumor cells, while having small effect ...
Somayeh Sadat Mehrnia +4 more
doaj +4 more sources
Bioactivity of 2'-deoxyinosine-incorporated aptamer AS1411. [PDF]
Sci Rep, 2016 AbstractAptamers can be chemically modified to enhance nuclease resistance and increase target affinity. In this study, we performed chemical modification of 2′-deoxyinosine in AS1411, an anti-proliferative G-rich oligodeoxynucleotide aptamer, which binds selectively to the nucleolin protein.
Fan X, Sun L, Wu Y, Zhang L, Yang Z.
europepmc +4 more sources
Targeted delivery of doxorubicin and therapeutic FOXM1 aptamer to tumor cells using gold nanoparticles modified with AS1411 and ATP aptamers [PDF]
Iranian Journal of Basic Medical Sciences, 2023 Objective(s): A targeted delivery platform was prepared to co-deliver both doxorubicin (Dox) as an anticancer drug and FOXM1 aptamer as a therapeutic substance to breast cancer cells (4T1 and MCF-7) to reduce Dox side effects and increase its therapeutic
Aref Abdollahzade +6 more
doaj +3 more sources
Modified AS1411 Aptamer Suppresses Hepatocellular Carcinoma by Up-Regulating Galectin-14.
PLoS ONE, 2016 Aptamers are small synthetic oligonucleotides that bind to target proteins with high specificity and affinity. AS1411 is an aptamer that binds to nucleolin, which is overexpressed in the cytoplasm and occurs on the surface of cancer cells.
Yuri Cho +11 more
doaj +5 more sources
Aptamer-engineered NIR-II Ru-doped carbon quantum dot nanozyme for photoacoustic imaging-guided synergistic photothermal and catalytic cancer therapy [PDF]
Journal of NanobiotechnologyCarbon quantum dot (CQD)-based nanozymes have attracted growing interest for advanced biomedical applications owing to their superior catalytic activity, photostability, and biocompatibility. However, the rational design of a multifunctional nanoplatform
Yumin Hao +8 more
doaj +2 more sources