Results 71 to 80 of about 2,316 (158)

Formulation optimization of lyophilized aptamer-gold nanoparticles: Maintained colloidal stability and cellular uptake

Heliyon
Anti-nucleolin (NCL) aptamer AS1411 is the first anticancer aptamer tested in clinical trials. Gold nanoparticles (AuNP) have been widely exploited for various biomedical applications due to their unique functional properties. In this study, we evaluated
Dalya Saidi, Marya Obeidat, Shrouq Alsotari, Abed-Alqader Ibrahim, Rula Al-Buqain, Suha Wehaibi, Dana A. Alqudah, Hamdi Nsairat, Walhan Alshaer, Alaaldin M. Alkilany   +9 more
doaj   +1 more source

The anti-tumor effect of chinese medicine extracts camptothecin -AS1411 system

Pharmacological Research - Modern Chinese Medicine
Introduction: The AS1411 aptamer has shown great potential in the development of targeted anti-tumor drug delivery systems. Camptothecin (CPT, Xǐshù Jiǎn), a cytotoxic quinoline alkaloid first isolated from the traditional Chinese medicine Camptotheca ...
Zhanbiao He, Zhen Wang, Lu Ga, Jun Ai, Xin Tong   +4 more
doaj   +1 more source

Nucleolin-Targeting AS1411 Aptamer-Modified Micelle for the Co-Delivery of Doxorubicin and miR-519c to Improve the Therapeutic Efficacy in Hepatocellular Carcinoma Treatment

International Journal of Nanomedicine, 2021
Xiao Liang,* Yudi Wang,* Hui Shi, Mengmeng Dong, Haobo Han, Quanshun Li Key Laboratory for Molecular Enzymology and Engineering of Ministry of Education, School of Life Sciences, Jilin University, Changchun, 130012, People’s Republic of China*These
Liang X, Wang Y, Shi H, Dong M, Han H, Li Q   +5 more
doaj  

Targeted delivery of doxorubicin to cancer cells by a cruciform DNA nanostructure composed of AS1411 and FOXM1 aptamers

Expert Opinion on Drug Delivery, 2018
Objectives: Here, a novel cruciform DNA nanostructure was developed for targeted delivery of doxorubicin (Dox), as an anticancer agent, to lung (A549 cells) and breast (4T1 cells) cancer cells. The cruciform DNA nanostructure consisted of AS1411 aptamer as targeting agent and Forkhead Box Protein M1(FOXM1) aptamer as therapeutic agent.
Khalil Abnous, Noor Mohammad Danesh, Mohammad Ramezani, Fahimeh Charbgoo, Amirhossein Bahreyni, Seyed Mohammad Taghdisi   +5 more
openaire   +2 more sources

Oxygen-producing and pH-responsive targeted DNA nanoflowers for enhanced chemo-sonodynamic therapy of lung cancer

Materials Today Bio
Lung cancer is the deadliest kind of cancer in the world, and the hypoxic tumor microenvironment can significantly lower the sensitivity of chemotherapeutic drugs and limit the efficacy of different therapeutic approaches.
Hongjian Liao, Yuchao Cao, Can Hu, Shangfeng Shen, Zhifei Zhang, Dairong Li, Yonghong Du   +6 more
doaj   +1 more source

A pH-Sensitive I-Motif Aptamer Probe for Dual Targeting and Imaging of Pancreatic Cancer Cells via Nucleolin Interactions

Journal of Bio-X Research
This study investigates the targeted imaging and tumor inhibition effects of a “signal-off” imaging-based activatable aptamer probe (I-AAP) for pancreatic cancer.
Quwen Li, Qingquan Chen, Juan Tang, Qicai Liu, Feng Gao   +4 more
doaj   +1 more source

ISEV2026 Abstract Book

Journal of Extracellular Vesicles, Volume 15, Issue S1, June 2026.
wiley   +1 more source

Advancing targeted combination chemotherapy in triple negative breast cancer: nucleolin aptamer-mediated controlled drug release

Journal of Translational Medicine
Background Triple-negative breast cancer (TNBC) is a recurrent, heterogeneous, and invasive form of breast cancer. The treatment of TNBC patients with paclitaxel and fluorouracil in a sequential manner has shown promising outcomes.
Yuan Ma, Duoli Xie, Zefeng Chen, Xinyang Shen, Xiaoqiu Wu, Feng Ding, Shijian Ding, Yufei Pan, Fangfei Li, Aiping Lu, Ge Zhang   +10 more
doaj   +1 more source

Targeting glutamine synthetase with AS1411-modified exosome-liposome hybrid nanoparticles for inhibition of choroidal neovascularization

Journal of Nanobiotechnology
Choroidal neovascularization (CNV) is a leading cause of visual impairment in wet age-related macular degeneration (wAMD). Recent investigations have validated the potential of reducing glutamine synthetase (GS) to inhibit neovascularization formation ...
Miaomiao Zhang, Xinyue Lu, Lifu Luo, Jinqiu Dou, Jingbo Zhang, Ge Li, Li Zhao, Fengying Sun   +7 more
doaj   +1 more source

As1411-modified liposomes to enhance drug utilization and augment the anti-tumor efficacy

Cancer Nanotechnology
Background The utilization of liposomes in drug delivery has garnered significant attention due to their efficient drug loading capacity and excellent biocompatibility, rendering them a promising platform for tumor therapy.
Danhuan Zhang, Lingyun Chen, Yang Zhao, Hao Ni, Qiuying Quan, Jun Ma, Lingchuan Guo   +6 more
doaj   +1 more source