Results 61 to 70 of about 2,316 (158)

Novel nanosized AS1411–chitosan–BODIPY conjugate for molecular fluorescent imaging

International Journal of Nanomedicine, 2019
Setareh Taki,1 Mehdi Shafiee Ardestani21Department of Radiopharmacy, International Campus, School of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran; 2Department of Radiopharmacy, Faculty of Pharmacy, Tehran University of Medical Sciences ...
Taki S, Ardestani MS
doaj  

Impact of Surface Functionalization on NV Quantum Properties: Implications for Biosensing with Fluorescent Nanodiamonds

Advanced Functional Materials, Volume 36, Issue 25, 26 March 2026.
Fluorescent nanodiamonds (fNDs) have emerged as an invaluable quantum sensing platform for biological and biochemical systems. This paper investigates the influence of common surface functionalization strategies for bioconjugation on the quantum properties of nitrogen vacancy (NV) centers in nanodiamonds.
Anja Sadžak, Iván Pérez, Mateja Guimarães, Lukas Spantzel, Fedor Jelezko, Michael Börsch, Anke Krueger   +6 more
wiley   +1 more source

RNA‐Binding Proteins and Ferroptosis in Cancer: Mechanism and Therapeutic Implications

MedComm – Oncology, Volume 5, Issue 1, March 2026.
Ferroptosis critically influences cancer cell fate and represents a promising therapeutic strategy. Emerging evidence identifies RNA‐binding proteins (RBPs) as key post‐transcriptional regulators of ferroptosis. The figure summarizes ferroptosis‐related RBPs across cancers: blue RBPs act as tumor suppressors by promoting ferroptosis, whereas red RBPs ...
Linlin Chang, Bin Lu, Haotian Shang, Wanjing Ding, Chunhua Wei, Xiaotian Qi, Pengxing He   +6 more
wiley   +1 more source

Light‐Activated Multifunctional Nanoplatforms: Reshaping Combination Therapy to Overcome Multidrug Resistance in Breast Cancer

Small Structures, Volume 7, Issue 3, March 2026.
Multidrug resistance in breast cancer constitutes a major therapeutic obstacle. This review examines light‐activated nanoplatforms combining photothermal and photodynamic therapies to overcome this challenge. Through rational design, these systems enable spatiotemporal control, enhanced tumor targeting, and synergistic antitumor efficacy.
Xianghui Duan, Gangcui Li, Hong Wang, Yanan Zhou, Hai Du, Qin Sun, Fulan Zhao, Luyin Yang, Pan Liang, Wei Ren   +9 more
wiley   +1 more source

PDIA3 Inhibition Facilitates Sensitivity of IKE‐Induced Ferroptosis via STAT3/LCN2 Axis to Improve Glioblastoma Therapy

Advanced Science, Volume 13, Issue 12, 27 February 2026.
In this manuscript, protein disulfide isomerase A3 (PDIA3) is identified as a key factor mediating the susceptibility of ferroptosis in GBM. Inhibition of PDIA3 enhances IKE or cystine starvation‐induced ferroptosis in GBM cells by resulting in the accumulation of lipid peroxidation and a reduction in GSH level.
Jie Zhang, Wei Wang, Xin Liu, Peifen Lu, Xinjing Liu, Qiucheng Nie, Siyuan Xin, Hong Li, Donglin Yu, Xinyue Zhang, Kailong Li, Xiaomin Han, Shuping Zhang, Wei Chong, Lili Sun, Wei Li, Tao Xin, Jin Jiao, Qiang Ma, Yiju Wei   +19 more
wiley   +1 more source

Evaluation of somatostatin and nucleolin receptors for therapeutic delivery in non-small cell lung cancer stem cells applying the somatostatin-analog DOTATATE and the nucleolin-targeting aptamer AS1411.

PLoS ONE, 2017
Cancer stem cells represent the putative tumor-driving subpopulation thought to account for drug resistance, relapse, and metastatic spread of epithelial and other cancer types.
Sif Holmboe, Pernille Lund Hansen, Helge Thisgaard, Ines Block, Carolin Müller, Niels Langkjær, Poul Flemming Høilund-Carlsen, Birgitte Brinkmann Olsen, Jan Mollenhauer   +8 more
doaj   +1 more source

Preparation of AS1411 Aptamer Modified Mn-MoS2 QDs for Targeted MR Imaging and Fluorescence Labelling of Renal Cell Carcinoma

International Journal of Nanomedicine, 2019
Shaohui Zheng,1–3,* Min Zhang,2,* Hongyan Bai,2 Meijuan He,2 Lina Dong,2 Lulu Cai,2 Mingming Zhao,2 Qi Wang,2 Kai Xu,1–3 Jingjing Li1–3 1Department of Radiology, Affiliated Hospital of Xuzhou Medical University, Xuzhou 221006, People ...
Zheng S, Zhang M, Bai H, He M, Dong L, Cai L, Zhao M, Wang Q, Xu K, Li J   +9 more
doaj  

AS1411 Aptamer Conjugated Gelatin-Siloxane Nanoparticles for targeted siRNA delivery

, 2017
RNA interference (RNAi) has potential advantages over other gene therapy approaches due to its high specificity and the ability to inhibit target gene expression. Thus, developing a stable, safe, effective siRNA delivery system is necessary to achieve targeted therapy.
Xueqin Zhao, Sijie Tao, Yongming Zhang, Dajin Wang, Lei Ren   +4 more
openaire   +1 more source

An intelligent poly aptamer-encoded DNA nanoclew for tumor site activated mitochondria-targeted photodynamic therapy and MR imaging

Materials Today Bio
Mitochondria-targeted photodynamic therapy (PDT) has emerged as one of the most promising antitumor therapies, as it significantly enhances the efficacy of photosensitizers. An efficient and biocompatible nanocarrier to deliver cationic photosensitizers (
Minghui Chen, Hanbo Xu, Pengzhao Chang, Xueqi Li, Shuang Liu, Lingyue Xu, Kai Xu, Guohui Cheng   +7 more
doaj   +1 more source

DDEL-09. AS1411 APTAMER-CONJUGATED NANOSPHERES FOR TARGETING GLIOBLASTOMA THERAPY

Neuro-Oncology
Abstract Postoperative chemotherapy remains essential for treating glioblastoma (GBM), with nanocarrier-based drug delivery emerging as the most efficient method. However, non-specific delivery across the blood-brain barrier (BBB) can limit drug accumulation in tumors and cause damage to nearby tissues.
Kim, Chae-Yong, Song, Yoon-Kyu, Seo, Kyeongjin, Hwang, Kihwan, Nam, Kyung Mi   +4 more
openaire   +1 more source