Results 51 to 60 of about 2,316 (158)

Engineering Extracellular Vesicles for Anti‐Aging Therapy: Mechanisms, Applications, and Perspectives

Aging Cell, Volume 25, Issue 7, July 2026.
This review systematically elucidates the multifactorial anti‐aging mechanisms of extracellular vesicles (EVs). By bridging fundamental biology with advanced bioengineering, scalable manufacturing, and clinical translation, it establishes a comprehensive framework for developing next‐generation EVs‐based precision nanotherapeutics to combat systemic ...
Xian Huang, Qiujie Li, Guofang Tao, Xulin Gan, Jiangjie Lu, Sergei Krasny, Liyun Shi   +6 more
wiley   +1 more source

Delivery of thymoquinone to cancer cells with as1411-conjugated nanodroplets.

PLoS ONE, 2020
Systemic delivery of conventional chemotherapies can cause negative systemic toxicity, including reduced immunity and damage to organs such as the heart and kidneys-limiting the maximum dose that can be administered.
Emily M Murphy, Connor S Centner, Paula J Bates, Mohammad T Malik, Jonathan A Kopechek   +4 more
doaj   +1 more source

A multi-storey DNA nanostructure containing doxorubicin and AS1411 aptamer for targeting breast cancer cells

Journal of Drug Targeting, 2022
Herein, we presented a novel DOX-loaded multi-storey DNA nanostructure, including AS1411 aptamer as a targeting agent for treatment of target cells (MCF-7 and 4T1). Gel retardation test and fluorometric analysis were used to examine the construction of DNA nanostructure and loading of DOX in the complex.
Elnaz Yaghoobi, TaranehSadat Zavvar, Mohammad Ramezani, Mona Alibolandi, Sara Rahimzadeh Oskuei, Mahsa Zahiri, Morteza Alinezhad Nameghi, Khalil Abnous, Seyed Mohammad Taghdisi   +8 more
openaire   +2 more sources

Nucleic Acid Therapeutics for “Undruggable” Cancer Targets: Mechanisms, Challenges, and Prospects

Advanced Science, Volume 13, Issue 36, 29 June 2026.
Nucleic acid therapeutics bypass the structural limitations of conventional drugs by targeting mRNA rather than proteins. This review examines how antisense oligonucleotides, siRNAs, miRNAs, aptamers, and mRNA vaccines intervene against historically undruggable oncoproteins including Ras, MYC, and p53, highlighting mechanistic advances, delivery ...
Feng Xu, Ke Wang, Kaizhong Lu, Tianlun Hou, Yuan Chen, Xian Wang, Hongchuan Jin   +6 more
wiley   +1 more source

Novel bispecific aptamer targeting PD-1 and nucleolin for cancer immunotherapy

Cancer Nanotechnology, 2023
Background Immune checkpoint blockade (ICB) is a promising strategy for cancer treatment and has achieved remarkable clinical results. Further improvement of ICB efficacy may advance cancer immunotherapy and has evident medical importance.
Junjun Fu, Fengjiao Yao, Yacong An, Xundou Li, Wenya Wang, Xian-Da Yang   +5 more
doaj   +1 more source

Cell Membrane Vesicles Encapsulating Il24 mRNA With Enriched CD6 Display Exhibit Enhanced Targeted Antitumor Efficacy

Journal of Extracellular Vesicles, Volume 15, Issue 6, June 2026.
ABSTRACT mRNA‐based therapeutics offer significant potential for cancer treatment owing to their ability to induce transient, non‐integrating expression of therapeutic proteins. However, effective and tumour‐specific delivery remains a major barrier.
Dandan Wang, Ruofan Gao, Duo Liu, Kefan Li, Runkai Wang, Minghe Xu, Shiwei Zhang, Shengjie Jiang, Bin Xia   +8 more
wiley   +1 more source

Potential of Covalent Organic Framework in Pharmacy and Biomedicine: Influence of Structure on Properties and Applications

ChemMedChem, Volume 21, Issue 9, 14 May 2026.
From modular COF design to biomedical translation, this Review maps how linkage chemistry, topology, pore environment, and particle engineering govern bioperformance, therapeutic and diagnostic function, safety, and clinical readiness. Covalent organic frameworks (COFs) are a versatile class of crystalline porous materials with growing potential in ...
Julia Kolodziejczyk, Marta E. Plonska‐Brzezinska   +1 more
wiley   +1 more source

Aptamer train formed by hybridization and enzymatic ligation for specifically delivering MTZ to colon cancer cells

Results in Chemistry
Multivalent interactions enhance targeted drug delivery by enabling stronger, specific binding to overexpressed receptors on target cells. This multivalent approach improves targeting efficiency, increases local drug concentration, and reduces off-target
Kanpitcha Jiramitmongkon, Pichayanoot Rotkrua, Paisan Khanchaitit, Jiraporn Arunpanichlert, Boonchoy Soontornworajit   +4 more
doaj   +1 more source

Aptamer‐Functionalized Nanocarriers for Bone and Joint Diseases: Engineering Design Rules and Translational Roadmap

Small Science, Volume 6, Issue 5, May 2026.
Aptamer‐functionalized nanocarriers represent a versatile platform for targeted therapy in bone and joint diseases. This review presents five complementary design strategies: free aptamers for soluble targets, bispecific multivalent constructs for enhanced avidity, nanoparticle‐conjugated aptamers for selective tissue accumulation, aptamer‐based ...
Hamdi Al‐Azzani, Djandan Tadum Arthur Vithran, Syeda Sundas Batool, Malek Mohammed Ali Alshabi, Wenhu Zhou, Xiaoqiang Mao   +5 more
wiley   +1 more source

Recent Advances in Tetrahedral Framework Nucleic Acids for Multimodal Synergistic Cancer Therapy

Aggregate, Volume 7, Issue 4, April 2026.
This review summarizes recent advances in tFNA‐based multimodal cancer therapy, including structural features, delivery strategies, and therapeutic regimens addressing key challenges in cancer treatment. We outline design principles, address translational hurdles, and highlight intelligent response and immune regulation as promising directions to ...
Zishan Huang, Zhitong Chen, Zhiyu Zhang, Hong Sun, Xujuan Li, Zhaogang Sun, Hongqian Chu, Wenjing Liu   +7 more
wiley   +1 more source