DNA nanostructure‐programmed intermembrane spacing to modulate T‐cell immunity
Clinical and Translational Medicine, 2023 Yulin Du, Liping Qiu, Weihong Tan
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Improved Aptamers for the Diagnosis and Potential Treatment of HER2-Positive Cancer
Pharmaceuticals, 2016 Aptamers provide a potential source of alternative targeting molecules for existing antibody diagnostics and therapeutics. In this work, we selected novel DNA aptamers targeting the HER2 receptor by an adherent whole-cell SELEX approach.
Marlies Gijs +6 more
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Aptamers for Detection and Diagnostics (ADD): Can mobile systems process optical data from aptamer sensors to identify molecules indicating presence of SARS-CoV-2 virus? Should healthcare explore aptamers as drugs for prevention as well as its use as adjuvants with antibodies and vaccines? [PDF]
, 2020 Shoumen Datta
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Advanced Science, EarlyView.An implantable hydrogel is designed to hold gene transfection agents engineered to turn early recurrent tumor cells into generators of synthetic EVs. These synthetic EVs can express engineered miR‐26a (E‐miR‐26a) for highly sensitive detection and PD‐1 (a PD‐L1‐blocking agent) for therapeutic intervention, thereby enabling early detection and ...
Junli Zhang +7 more
wiley +1 more source
Aptamers for CD Antigens: From Cell Profiling to Activity Modulation
Molecular Therapy: Nucleic Acids, 2017 Nucleic acid-based aptamers are considered to be a promising alternative to antibodies because of their strong and specific binding to diverse targets, fast and inexpensive chemical synthesis, and easy labeling with a fluorescent dye or therapeutic agent.
Amin Nozari, Maxim V. Berezovski
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Site-specific replacement of the thymine methyl group by fluorine in thrombin binding aptamer significantly improves structural stability and anticoagulant activity [PDF]
, 2015 Antonella Virgilio +10 more
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Advanced Science, EarlyView.A deep comprehension of biomolecular phenomena at interfaces is significant with their fundamental and practical importance. Our experimental and theoretical investigations reveal that specific amino acids (glutamic acid and aspartic acid) exhibit an orientational coupling with liquid crystals, which can recognize and optically report the interfacial ...
Yena Choi +10 more
wiley +1 more source
Reducing Toxicity of Immune Therapy Using Aptamer-Targeted Drug Delivery [PDF]
, 2015 Eli Gilboa +2 more
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CRISPR/Cas13a: Compensatory Target Activation Mechanism
Advanced Science, EarlyView.CRISPR/Cas13a‐CTAM as a novel compensatory target activation mechanism that enables synergistic activation of Cas13a via two independently editable short RNA effectors. This dual‐effector system maintains enzymatic activity comparable to traditional single‐effector while significantly enhancing flexibility, sensitivity, and application scope.
Bowen Jiang +8 more
wiley +1 more source
Biolipid Film‐Fused Electrochemiluminescence for Multipurpose In Situ Bioassays
Advanced Science, EarlyView.An ECL‐emissive, membrane‐interactive scaffold was fabricated, and facilely fused with natural and non‐native phospholipids into multifactorial mimicries of cytomembranes and vesicles for in vitro representative membrane‐process probing. Such a biointerface‐based, state‐sensitive ECL paradigm not only pinpointed proximal phenomena, including channeling
Jialiang Chen +9 more
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